Indiana University

This study tested whether automated phone reminders, real-time appointment alerts, and motivational counseling could help more children complete their routine vaccines on time. Over 2,800 parents and caregivers in a low-resource setting took part. The goal was to see if a simple …

This early-stage trial tested whether injecting donor stem cells into the leg muscles of people scheduled for amputation could prevent complications like poor wound healing and reduce the chance of needing more amputations. 81 patients with severe leg artery disease received the …

This completed Phase 4 trial tested whether buspirone, a drug used for anxiety, can reduce irritability and aggression in people who have had a traumatic brain injury. 81 adults aged 18-70 with a closed head injury at least 6 months prior took either buspirone or a placebo for 91…

This study looked at how well endoscopic stenting and suturing work to close holes or tears in the esophagus. Researchers reviewed 150 patients treated at a large referral center. The goal was to see which technique leads to better healing.

This study looked at whether children with cystic fibrosis (CF) who are taking CFTR modulator drugs and have regained normal pancreatic function can safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months after stopping enz…

This early-phase trial tested whether a virtual reality (VR) experience, where participants see an avatar that looks like them in a park, could help people in early recovery from opioid use disorder reduce drug use and stay abstinent. The study enrolled 104 people who were alread…

This study tested whether delivering coordinated specialty care (CSC) via telehealth works as well as standard in-person care for young people (ages 16–35) with early psychosis. Over 12 months, researchers tracked hospitalizations and engagement in 74 participants. The goal was t…

This study tested whether a 3D intraoral scanner can detect cavities, tooth wear, and fluorosis in children's baby teeth as accurately as a traditional visual exam. Thirty-six children aged 3 to 12 had their teeth cleaned, then examined both visually and with a 3D scan during a s…

This study tested whether a dye called Cytalux, which makes cancer cells glow under a special light, can help surgeons find and remove more prostate cancer during surgery. Nine men with aggressive prostate cancer received the dye before their prostate removal surgery. The goal wa…

This study tested whether a portable eye-tracking device can help diagnose autism in young children in Kenya. Researchers measured how 27 children looked at images and compared the results to standard clinical diagnoses. The goal was to see if this quick, non-invasive method coul…

This study tested whether daily zinc supplements can lower the number of severe infections in young children (ages 1 to 5) with sickle cell anemia. Researchers in Uganda gave 100 children either zinc or a placebo (fake pill) and tracked how many got sick. The goal was to see if z…

This completed trial tested a virtual program for people with Alzheimer's or related dementias and their caregivers. Nearly 1,000 participants received monthly video or phone visits from nurses or social workers over a year. The program focused on managing symptoms, reducing care…

This study tested a special type of radiation therapy that moves with your breathing to treat pancreatic cancer. It included 36 people whose cancer could not be removed by surgery, had come back, or was still there after other treatments. The main goal was to see how safe this ra…

This study tested a new digital system for creating prosthetic sockets while the person is standing (weight-bearing). The goal was to see if this method leads to a better fit, more comfort, and improved skin health compared to traditional non-weight-bearing methods. Ten adults wi…

This small pilot study tested the Safe and Sound Protocol (SSP), a passive listening program, in 45 adults with PTSD or anxiety. Participants listened to specially filtered music as a 'neural exercise' to help regulate their body's stress response. The study measured changes in P…

This study tested a program called UPLIFT-AD that brings palliative care—a type of care focused on comfort and quality of life—into nursing homes for people with moderate to severe Alzheimer's disease. The program trained nursing home staff and provided access to specialist palli…

This study looked at whether special breathing muscle training could reduce asthma symptoms triggered by exercise and improve cycling performance. Fifteen athletes with mild to moderate asthma or exercise-induced bronchoconstriction completed the training. Researchers measured lu…

This study tested a program to help veterans with Alzheimer's disease or traumatic brain injury and the family or friends who care for them. The goal was to see if the program could improve the caregivers' quality of life and reduce their stress. About 236 veterans and their care…

This study tested whether eating beef daily for 8 weeks reduces muscle fatigue in adults aged 60-85 compared to a vegetarian diet. Twenty-four participants ate both diets in a crossover design, with tests like sit-to-stand and walking. The goal was to see if beef's natural beta-a…

This study looked at whether playing virtual reality games (like Nintendo Switch Sports) could help improve balance in 13 young people with autism, compared to doing standard physical therapy exercises. Participants did 6 sessions over 2 weeks from home, supervised via Zoom. Rese…

This study looked at whether high-intensity walking training is better than lower-intensity walking exercise for people with chronic, motor incomplete spinal cord injury. Researchers measured walking speed and distance in 53 participants. The goal was to find a more effective way…

This study tested whether standing on a low-intensity vibrating platform for 10 minutes twice a day for 12 months could improve muscle function and reduce pain in early-stage breast cancer survivors starting aromatase inhibitor therapy. 72 women who did not exercise regularly wer…

This study tested whether listening to slow-tempo music for seven days could help older adults in the intensive care unit (ICU) avoid delirium—a state of confusion that can lead to longer hospital stays and memory problems. Researchers enrolled 160 patients aged 50 and older who …

This study compared two methods for breaking up large stones in the pancreatic duct: external shock waves (ESWL) and a newer technique using a tiny scope inside the duct (SOPIL). Thirty adults with chronic pancreatitis and painful, large stones took part. The goal was to see whic…

This study created a database of information from 105 stroke patients who had a procedure to remove a large blood clot from the brain. Doctors used a special wire to help guide a tube to the clot. The goal was to see if the wire alone could get the tube to the right spot. This wa…

This study tested a program called APPROACHES in nursing homes to improve advance care planning for residents with Alzheimer's disease and related dementias. The program trained staff and helped families discuss treatment wishes ahead of time. Researchers tracked whether this red…

This study tested whether using a breathing training device (PrO2 Fit) four times a week for 8 weeks could improve cardiovascular health and mood in postmenopausal women aged 50-75. Researchers measured how quickly the women's oxygen use responded during exercise and how far they…

This study tested whether showing people in early recovery from alcohol use disorder personalized, high-intensity images of future events could help them think more about long-term rewards and increase their interest in treatment. Fifty-eight participants were split into two grou…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study tested a new type of camera that can see the tiny cells in the back of the eye, called the retina. Current cameras can't show these cells clearly. Five people with retinal disease had their eyes scanned with this new camera to see if it could show more detail. The goal…

This study checked if a smartphone app called VisionApp can accurately measure vision problems like nearsightedness and presbyopia (age-related reading difficulty). Sixteen adults aged 40 and older used the app at home, and their results were compared to standard eye exams. The g…

This study looked at how powered ankle prostheses change the pressure inside the prosthetic socket and the health of the residual limb in people with below-knee amputations. Six adults who already use a standard prosthetic leg walked on level ground with different types of prosth…

This study looked at how different parts of the brain work together to keep hand movements precise. 76 healthy adults had their brain activity measured with MRI scans while resting and performing tasks. The goal is to understand normal brain function, which may one day help impro…

This study tested a program called Patient Priorities Care in 178 people with dementia or mild cognitive impairment. Participants received a packet before their clinic visit and could talk with a trained facilitator about their personal healthcare goals. The study aimed to see if…

This study looked at how to make surgical residency programs better and less stressful for doctors in training. Researchers collected information from over 200 US surgery programs about burnout, mistreatment, and other problems. The goal was to find ways to improve the workplace …

This study tested a computer system that gives ER doctors a risk score showing which adult patients might have social needs like trouble with housing, food, or transportation. The goal was to see if this tool helps doctors screen and refer more patients to support services. Over …

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at whether taking progesterone (in women) or testosterone (in men) could reduce dangerous changes in heart rhythm caused by certain medications. 73 healthy older adults (postmenopausal women and men 65+) took either the hormone or a placebo, then received a smal…

This study looked at how different parts of the brain help us sense where our limbs are and learn new hand movements. Researchers tested 118 healthy adults using a robot to measure arm position awareness and a maze-tracing task to track motor skill learning. The goal is to use th…

This study tested a method called public deliberation, where community members learn about a topic, hear different views, and discuss it together to find fair solutions. Researchers wanted to see if this approach could improve how teens from marginalized communities give consent …

This study looked at how cannabidiol (CBD) interacts with tacrolimus, a drug used to prevent organ rejection in transplant patients. Researchers wanted to understand how to adjust doses for better health outcomes. The study involved 57 healthy adults and those with chronic kidney…

This study looked at how a single high-salt meal affects blood pressure and blood vessel function in healthy adults aged 19-40. Researchers compared Black and white participants to see if there are racial differences in how the body handles salt. The goal is to understand why Bla…

This study tested whether vitamin C (ascorbic acid) tablets can temporarily lower stomach pH in healthy young men whose stomach acid was reduced by a common heartburn drug. Eleven participants took vitamin C and had their stomach pH monitored for five hours. The goal was to see i…

This study looked at 98 adults with cancers like melanoma and lung cancer who were starting immunotherapy. Researchers measured inflammatory markers in their blood to understand how the body reacts to these drugs. The goal was to find ways to better manage side effects from treat…

This study tested a special communication program for doctors and parents of children with advanced cancer. The goal was to help families and doctors agree on treatment goals, especially for children nearing end of life. Researchers measured whether this improved the child's qual…

This study tested a streamlined HIV care approach for pregnant and postpartum women and their infants at a hospital in Kenya. The goal was to see if offering simpler, more flexible services could reduce clinic wait times and keep mothers and babies healthy. Researchers tracked vi…

This study looked at whether playing music during gym class helps kids be more active and enjoy exercise more. 26 fifth and sixth graders took part in an 8-week sports program, with some classes having music and others not. Researchers measured steps, mood, and motivation to see …

This study tested a computer program that helps doctors diagnose common stomach and bowel problems in children. 33 children and their doctors took part. The goal was to see if the tool leads to more accurate diagnoses and better care.