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Breathing training may ease asthma symptoms during exercise

NCT ID NCT06336681

Symptom relief Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a special breathing exercise, called flow-resistive inspiratory muscle training, could reduce the severity of exercise-induced bronchoconstriction (EIB) in athletes with asthma. Fifteen competitive cyclists or athletes aged 18-35 completed the training and were measured on lung function, breathing effort, and cycling performance. The goal was to see if strengthening the breathing muscles could help control asthma symptoms during exercise and improve time-trial results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Flow-resistive inspiratory muscle training using the PrO2Fit device
What this could lead to
If it works, this could offer a non-drug way to ease breathing problems during exercise for people with asthma.
What could go wrong
This is a small, completed study with only 15 participants, so results may not apply to everyone. The training is demanding and may not be practical for all athletes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

15 people

The number who actually took part.

Started

Feb 2022

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female, between the ages of 18 to 35 years. * Required to be a competitive recreational or college athlete and have at least 1-2 years of cycling or biking experience. * Body Mass Index (BMI) of 18.5 to 28 kg/m\^2 * Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ). * Have clinically treated mild to moderate persistent asthma and/or exercise-induced bronchoconstriction (EIB), with a resting forced expiratory volume in 1 second (FEV1) \> 65% of predicted. * A ≥ 10% drop in FEV1 after eucapnic voluntary hyperpnea (EVH). * Prescribed short-acting β2-agonists (SABAs) by a physician. * Comfortable not taking SABA before experimental visits. Exclusion Criteria: * History of smoking or recreational smoking, cardiovascular disease, renal disease, neurological disease, and metabolic disease. * Currently taking asthma maintenance medications (e.g., corticosteroids and leukotriene modifiers) * Any injuries in the past 6 months. * Taking selective serotonin reuptake inhibitors (SSRI)'s (antidepressants and anxiety medication), attention-deficit hyperactivity disorder (ADHD) medication, and chronically consume pain medication (Aleve, Tylenol, cannabidiol (CBD), etc.). * Has had or is positive for COVID-19. * Resting blood pressure of \> 130 mmHg systolic or 90 mmHg diastolic. * Resting Pulse rate of \> 100 bpm. * Regularly consuming fish oil supplements or eating more then one fish meal per week

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Conditions

The condition(s) this trial relates to.

asthma Asthma, Exercise-Induced chronic asthma exercise-induced bronchoconstriction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exercise induced asthma Exercise induced bronchospasm

Contacts and locations

Locations

  • School of Public Health-Bloomington

    Bloomington, Indiana, 47405, United States

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