CF breakthrough: kids may ditch daily enzyme pills after modulator treatment
NCT ID NCT07632768
First seen Jun 10, 2026 · Last updated Jun 20, 2026 · Updated 3 times
Summary
This study looked at whether children with cystic fibrosis (CF) who are taking CFTR modulator drugs and have regained normal pancreatic function can safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months after stopping enzymes. Researchers monitored their growth, nutrition, and digestive symptoms to see if stopping enzymes caused any problems.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CFTR modulator therapy (ivacaftor, elexacaftor/tezacaftor/ivacaftor, or vanzacaftor/tezacaftor/deutivacaftor)
What this could lead to
If successful, this could show that some children with CF can safely stop taking daily pancreatic enzyme pills, simplifying their treatment and improving quality of life.
What could go wrong
This is a small, completed study with only 17 participants, so results may not apply to everyone. Stopping enzymes could cause nutritional problems or worsen symptoms in some children.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.