Can a common anxiety drug tame TBI-Related anger?
NCT ID NCT01821690
First seen Nov 20, 2025 · Last updated Jun 20, 2026 · Updated 25 times
Summary
This completed Phase 4 trial tested whether buspirone, a drug used for anxiety, can reduce irritability and aggression in people who have had a traumatic brain injury. 81 adults aged 18-70 with a closed head injury at least 6 months prior took either buspirone or a placebo for 91 days. The study measured changes in irritability and aggression using observer ratings.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Indiana University and Rehabilitation Hospital of Indiana
Indianapolis, Indiana, 46254, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
buspirone (Buspar)
What this could lead to
If it works, this could provide a medication option to help people with traumatic brain injury manage irritability and aggression.
What could go wrong
This is a small, completed Phase 4 trial with only 81 participants. Results may not apply to everyone, and buspirone may cause side effects like dizziness or nausea.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.