Indiana University

This study compares two methods for removing certain types of colon polyps (10-19mm adenomas or serrated lesions 10mm or larger) during a colonoscopy: cold snare piecemeal resection (CSPR) and cold snare endoscopic mucosal resection (Cold EMR). About 570 adults will take part to …

This study looks at whether reducing or stopping additional treatments (like chemo or radiation) after surgery for HPV-positive throat cancer can still prevent the cancer from coming back. The goal is to maintain good outcomes while avoiding harsh long-term side effects. About 83…

This study tests whether a monitored ketogenic diet is safe and effective for weight loss in 40 obese adults with compensated NASH cirrhosis. Participants are randomly assigned to either a ketogenic diet or standard dietary advice for 16 weeks. The main goals are to check for liv…

This study tests a program called PATH4YOU that helps women get birth control and pregnancy planning support when they need it. The program includes counseling, a decision aid, and same-day access to contraception at clinics. Researchers will enroll 1,200 women aged 18-49 in Indi…

This study aimed to test whether a supplement called chondroitin sulfate is safe for newborns with necrotizing enterocolitis (NEC), a severe gut infection. Researchers planned to compare babies who received the supplement with those who got a placebo, looking at survival, need fo…

This study tests a modified soft contact lens to measure pressure inside the skulls of babies at risk for hydrocephalus (fluid buildup in the brain). About 25 infants will wear the lens during standard checkups and before/after surgery. The goal is to see if the lens can accurate…

This study tests whether special soft contact lenses with built-in sensors can safely and accurately measure eye pressure continuously for 24 hours in people with glaucoma and in healthy adults. Researchers will compare the smart lens readings to standard eye pressure tests and c…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This study is tracking up to 5,000 adults with achalasia who undergo a procedure called POEM. POEM uses a scope through the mouth to cut the tight muscle at the bottom of the esophagus, helping food and liquid pass more easily. The goal is to see if the procedure improves swallow…

This study aimed to see if using a special nasal mask that provides positive airway pressure (PAP) during colonoscopy sedation could reduce the frequency, length, and severity of low oxygen levels compared to standard oxygen through a nasal cannula. The study planned to enroll hi…

This study tests whether people with sickle cell disease can reduce their pain by doing acupressure on themselves at home using a simple tool called AcuWand. Three hundred adults will either perform real or sham acupressure every other day for five weeks. Researchers will measure…

This pilot study aimed to test whether a virtual reality cooking simulation could improve arm movement in people with acquired brain injury. Participants would have used VR to practice reaching, grabbing, and stirring motions. However, the trial was withdrawn before enrolling any…

This study looks at whether acupuncture can help manage chronic pain in people with sickle cell disease. Researchers will use brain scans and other tests to understand how acupuncture affects pain signals. The study involves 60 participants aged 14 to 80 who have sickle cell dise…

This study aimed to see if a combination of remimazolam and fentanyl could safely sedate patients during dental extractions lasting 30 minutes or less. It planned to enroll healthy adults needing tooth removal. However, the trial was withdrawn before any participants were enrolle…

This early-phase study tests whether adding lacosamide, a seizure medication, to opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. The goal is to reduce a condition called opioid-induced hyperalgesia, where opioids actually make…

This study tests an experimental inhaled nasal spray called Optate in 24 adults with mild COVID-19. Researchers measure how well it lowers virus levels in the nose and eases symptoms like congestion and discomfort over 24 hours. The goal is to see if this treatment can provide qu…

This study tests whether a combination of virtual reality exercises and computer-based cognitive training can improve memory and thinking in 172 older adults (55+) who have both heart failure and mild cognitive impairment. Participants will use VR and computer programs designed t…

This study is testing a new tool called PATH that helps doctors assess and manage age-related health problems in people aged 50 and older living with HIV. The tool asks patients questions about their health through an online portal or with help from a research coordinator before …

This study tests whether electrically stimulating a nerve in the ear can reach the internal vagus nerve, which controls stomach function. Researchers will measure nerve signals and stomach activity in 131 healthy volunteers and people with gastroparesis. The goal is to see if thi…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study tests whether showing parents an infographic about sleep apnea symptoms helps them talk to their child's doctor. About 200 children with snoring and other symptoms will take part. Half of parents see the infographic before a checkup; the other half get usual care. Rese…

This study tests whether a mild electrical current applied to the ear can activate the vagus nerve, which controls stomach function. Thirty healthy volunteers will receive ear stimulation and perform simple maneuvers like coughing. Researchers will measure nerve activity and stom…

This study is testing a remote rehabilitation program called ICARE for people who have had a traumatic brain injury (TBI) and their care partners. The goal is to see if the program can help improve how people with TBI recognize and respond to others' emotions. About 85 participan…

This study aims to improve how breath samples are collected and analyzed to find better ways to measure lung health. Researchers will collect breath from up to 1,000 people, including healthy volunteers and those with respiratory or inflammatory conditions. No treatments or medic…

This observational study will follow 125,000 adults with employer-based insurance to see how GLP-1 and GLP-1/GIP obesity medications (like Wegovy and Zepbound) affect weight, healthcare use, and costs. Researchers will compare those who take the drugs to those who don't, using ex…

This study is gathering information from 500 people who had a procedure called TIF (transoral incisionless fundoplication) to treat GERD, or chronic acid reflux. Researchers will review medical records to see how symptoms and quality of life change over time. No new treatment is …

This study is testing a decision aid to help patients and their doctors talk about colorectal cancer screening options. About 400 people in Indiana will take part. The goal is to see if the tool improves shared decision-making and increases screening rates.

This study tests whether shining a UV flashlight on the skin changes nitric oxide levels, as part of developing a new, noninvasive way to measure certain molecules in the body. Researchers will recruit 150 healthy adults and children, expose their ear lobes, hands, or foreheads t…

This study looks at how CFTR modulators, a type of cystic fibrosis treatment, affect bone strength and muscle mass in adults with CF. Researchers will measure changes in bone density and lean body mass over 12 to 24 months. The goal is to understand whether these treatments help …

This study looks at 200 people with ongoing stomach discomfort (functional dyspepsia) to find out how often they have small intestinal bacterial overgrowth (SIBO). Researchers will compare two methods—growing bacteria in a lab and DNA testing—to identify which germs are present. …

This research studies a program that places social workers in 25 children's doctor offices across Indiana. The goal is to help doctors spot and treat mental health issues like depression and anxiety sooner. About 575 patients and staff will take part to see if this approach impro…

This study tests new strategies to make sure that decisions about who gets a heart transplant or a heart pump are fair and based on objective medical criteria, not bias. Researchers will work with over 1,400 patients and doctors at heart centers across the U.S. to reduce racial a…

This study compares how full and satisfied people feel after eating a high-protein snack bar versus a high-carbohydrate snack bar. About 150 healthy adults aged 18-65 with a normal or slightly overweight BMI will participate. Each person visits twice, eating one type of bar each …

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study looks at whether two types of telemedicine (remote doctor visits) can help children with sickle cell disease in areas with limited medical access. About 24 families will try these models to see if they make it easier to keep appointments and get lab tests. The goal is …

This study aims to improve how overdose fatality review teams work by giving them a data dashboard and training. Instead of reviewing just one or two cases at a time, teams will use near real-time data to spot patterns and make better recommendations. About 400 team members and l…

This study looks at how a device that electrically stimulates the stomach (gastric electrical stimulation) affects the vagus nerve and heart rate in people with gastroparesis, a condition where the stomach empties slowly. Researchers will measure heart signals and hormone levels …

This study looks at how the vagus nerve works in people with gastroparesis (stomach paralysis) who already have a gastric electrical stimulator device. Researchers will use a flexible, non-invasive electrode patch on the neck to measure nerve signals and link them to symptom reli…

This study is creating a new tool for children with spina bifida and their doctors to work together on setting personal goals for managing bladder and bowel leakage. The goal is to improve the child's quality of life by focusing on what matters most to them, rather than just medi…

This study follows 180 infants from birth to age 2 to see how bacteria in their upper airways change over time. Researchers want to learn if certain bacteria lead to more airway inflammation and lower lung function, which could increase asthma risk. The study does not test any tr…

This study looks at how to help rural clinics in Indiana get more people screened for colorectal cancer. Clinics will mail test kits, send text reminders, and use patient navigators to guide adults aged 45-75 through the screening process. The goal is to see which methods work be…

This study tests whether an AI tool that uses electronic medical records can help predict and reduce delirium (sudden confusion) in older adults after major surgery. About 60 people aged 65 and older will take part. The goal is to see if giving doctors a delirium risk alert can l…

This study looks at how premature birth affects lung development in babies during their first year. Researchers will measure lung function in about 250 infants to identify patterns that may predict future breathing issues. The goal is to better understand which babies are at high…

This study collects blood samples from 19 adults with metastatic melanoma or kidney cancer that shrank without treatment (spontaneous regression). Researchers want to study immune cells and other factors that might explain why the cancer went away. The goal is to learn how the bo…