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Can pressing these points ease sickle cell pain?

NCT ID NCT06511453

Symptom relief Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests whether people with sickle cell disease can reduce their pain by doing acupressure on themselves at home using a simple tool called AcuWand. Three hundred adults will either perform real or sham acupressure every other day for five weeks. The goal is to see if this technique lowers pain intensity and interference in daily life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acupressure using a tool called AcuWand
What this could lead to
If it works, this could offer a simple, drug-free way to manage chronic pain in sickle cell disease at home.
What could go wrong
This is an early-stage trial with a sham comparison, so results may show no benefit. Pain is subjective, and the effect may vary widely among participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

59 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Any gender * 18-80 (Adults) years old * Have been diagnosed with SCD and experiencing chronic pain in the past 6 months or vaso-occlusive crisis/crises in the past 12 months. * Either outpatient or inpatient or status changing between each other * Willing to limit the current and the introduction of any new medications or treatment modalities for control of pain symptoms during the study visits. * Willing to stick to the scheduled acupressure treatments every other day for 5 weeks. * Fluent in English and capable of giving written informed consent. Exclusion Criteria: * Recent/ongoing alternative pain management with acupuncture/acupressure or acupuncture/acupressure-related techniques within the last 6 months. * Presence of a concurrent autoimmune or inflammatory disease such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, etc. that causes pain or any other chronic pain condition with pain greater than sickle pain. * Diseases/conditions history includes but not limited to: * Head injury with substantial loss of consciousness * Known non-SCD-related severe psychiatric illnesses (e.g. current schizophrenia, major depression with suicidal ideation). * Significant visual, motor, or auditory impairment that would interfere with ability to perform study visits-related activities

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Conditions

The condition(s) this trial relates to.

Pain sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sickle cell disease

Contacts and locations

Locations

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46075, United States

  • University of California, Irvine

    Irvine, California, 92868, United States

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