Could a psoriasis drug help thickened hands and feet?
NCT ID NCT06561321
First seen Jan 28, 2026 · Last updated Jun 22, 2026 · Updated 23 times
Summary
This study tests a daily cream called tapinarof, already used for psoriasis, in 6 adults with palmoplantar keratoderma — a condition that causes painful thickening of skin on the palms and soles. Researchers want to see if the cream can clear or improve the skin and check for side effects. It's a small, early-phase trial at Indiana University.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Indiana University Department of Dermatology
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tapinarof cream
What this could lead to
If it works, this could point toward a new topical treatment for palmoplantar keratoderma, a rare skin condition with limited options.
What could go wrong
This is a very small early-phase trial with only 6 participants, so results may not apply to everyone. The drug may not work or could cause side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.