Gene test could prevent risky drug interactions in HIV patients
NCT ID NCT05789173
First seen Feb 23, 2026 · Last updated Jun 19, 2026 · Updated 18 times
Summary
This study looks at how a person's genetic makeup and the HIV drug efavirenz change the way the body processes methadone and tizanidine. Sixty healthy volunteers will be grouped by their CYP2B6 gene type and take these drugs with and without efavirenz. The goal is to understand why some people may get too much or too little drug effect, which could lead to safer dosing in the future.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Indiana University School of Medicine
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone, Tizanidine, Efavirenz
What this could lead to
If successful, this could help doctors predict and avoid dangerous drug interactions in people taking efavirenz with methadone or tizanidine.
What could go wrong
This is an early-phase study in 60 healthy volunteers, not patients. Results may not apply to real-world clinical settings or people with HIV.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.