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Brain zapping trial targets 'Rumination' in Tough-to-Treat depression

NCT ID NCT06511544

First seen Nov 01, 2025 · Last updated Jun 14, 2026 · Updated 26 times

Summary

This pilot study tests whether a non-invasive brain stimulation technique called TMS can reduce rumination—repetitive negative thinking—in adults with treatment-resistant depression. Twenty participants will receive 20 TMS sessions targeting a specific brain region and undergo brain scans to see if brain activity changes. The goal is to understand if this approach can ease a common and distressing symptom.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Goodman Hall Neuroscience Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.