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Fish oil may protect soccer Players' brains from heading impacts

NCT ID NCT06736925

Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking fish oil supplements (DHA and EPA) before soccer heading can reduce brain injury markers. 208 soccer players aged 18-30 will take either fish oil or placebo capsules daily, then undergo controlled heading sessions. Researchers will measure blood biomarkers, brain scans, and nerve function to see if the supplements offer protection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Omega-3 fatty acids (DHA and EPA) from fish oil
What this could lead to
If it works, this could point toward a simple dietary supplement that helps protect the brain from repeated mild head impacts.
What could go wrong
This is an early mechanistic study, not a treatment trial. The results may show no benefit, and the supplement cannot prevent all brain injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 208 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between age 18-30 * Current or former soccer player * At least 5 years of soccer heading experience * Have internet access * Willing to commit to avoid any sport activity that purposefully uses one's head to maneuver during the study period (American football, ice-hockey, rugby, wrestling, and soccer heading). Exclusion Criteria: * Any head or neck injury within 6 months before the study * Implanted metal/magnetic devices (e.g., orthodontic braces * Diagnosed autonomic or cardiovascular diseases (e.g., hypertension) * Consuming oily fish (2 servings or more/month: salmon, bluefin, swordfish, anchovies) * Allergy to fish or shellfish * Consuming omega-3 FA supplements including plant-based (e.g., flaxseed) in the past 3 months. * Pregnancy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Omega-3 fatty acids Subconcussive head impact

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Indiana University School of Public Health

    RECRUITING

    Bloomington, Indiana, 47405, United States

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