Which painkiller works best after major head and neck surgery?
NCT ID NCT06784999
First seen May 02, 2026 · Last updated Jun 19, 2026 · Updated 11 times
Summary
This study compares two pain medicines, sufentanil and methadone, given during and after head and neck reconstruction surgery. About 128 adults will be randomly assigned to receive one of the drugs. Researchers will track pain levels and how much extra pain medicine is needed to see which option works better.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sufentanil and methadone
What this could lead to
If this trial succeeds, it could show that one of these pain medicines works better for controlling pain after head and neck reconstruction surgery, leading to improved recovery and less opioid use.
What could go wrong
This is a small, early-phase study (128 participants) comparing two existing drugs, so results may not apply to all patients. There is always a risk of side effects from opioids, such as nausea or drowsiness.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.