Nyu Langone Health

This study follows 5,391 people with stable heart disease for up to 10 years to see which initial treatment approach helps people live longer. Participants were originally assigned to either receive heart procedures plus medications or medications alone. Researchers are now track…

This study is testing whether an automated computer alert can help doctors prescribe the recommended medications for people with heart failure. The alert pops up in patients' electronic health records when they visit their cardiologist. Researchers want to see if this reminder sy…

This study is testing a support program to help Black patients with uncontrolled high blood pressure. It connects nurses, community health workers, and remote monitoring tools within 25 primary care clinics. The goal is to see if this team-based approach helps patients lower thei…

This study is testing whether playing very low, gentle sounds through headphones during sleep can help reduce seizures and abnormal brain activity in adults with epilepsy. Researchers are checking if people can comfortably use the sound system at home every night and measuring if…

This early-stage study is testing whether combining two immunotherapy drugs with two standard chemotherapy drugs is safe for pancreatic cancer patients before surgery. The main goal is to find the right dose that doesn't cause too many side effects. Researchers will also check if…

This study aims to find the best ways to help people with opioid addiction stay in treatment and, for some, eventually stop their medication safely. It involves over 1,500 adults and tests different combinations of medication and support strategies. The goal is to help people ach…

This pilot study is testing two different phone-based support programs to help people living with HIV in South Africa reduce or quit smoking. Researchers are comparing e-cigarettes to nicotine patches, both combined with motivational text messages and counseling. The goal is to f…

This study aims to improve care for people living with dementia and their caregivers after an emergency room visit. It tests different coaching programs to help connect families with community support and services. The goal is to improve care quality, satisfaction, and reduce fut…

This study is testing a new technique for cochlear implants, which are devices that help people with severe hearing loss. Standard implants only stimulate part of the inner ear, missing the areas for lower-pitched sounds. The new method aims to stimulate the entire ear using the …

This study is testing whether adding a drug called tocilizumab to two existing immunotherapy drugs (ipilimumab and nivolumab) is safe and effective for people with advanced melanoma that cannot be removed by surgery. The trial involves 71 participants and will measure side effect…

This study aimed to compare two ways of performing ACL (knee ligament) reconstruction surgery. It planned to see if adding an internal brace for extra support to a standard quadriceps tendon graft would lead to better healing and function one year after surgery. The study was wit…

This study is comparing two ways to perform total shoulder replacement surgery for people with severe arthritis. About 120 patients will be randomly assigned to get either the traditional surgery or a newer 'rotator cuff sparing' technique that avoids cutting a major shoulder ten…

This study is testing whether a targeted radiation therapy called Lutathera can control the growth of meningioma brain tumors in adults. It will involve 32 participants with progressive or high-risk tumors that have a specific marker showing they might respond to this treatment. …

This study tested whether a shorter, 3-day radiation schedule is as safe and effective as the standard 5-day schedule for early-stage breast cancer. It involved 284 postmenopausal women who had small tumors removed with surgery. The goal was to see if reducing treatment days coul…

This study is adapting and testing a therapy designed to help people who are dealing with post-traumatic stress disorder (PTSD) while also using multiple drugs, like cocaine and opioids. The therapy is being offered within a methadone treatment program in New York City. Researche…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to a standard combination of chemotherapy (gemcitabine) and radiation is a safe and effective way to treat muscle-invasive bladder cancer. The goal is to control the cancer and avoid surgically removing th…

This study is testing if a 15-week guided breathing program can help people who have had Takotsubo syndrome, a temporary heart condition often triggered by stress. Researchers will measure how well the program helps regulate the body's automatic nervous system, which controls hea…

This study is testing whether a non-invasive light therapy, aimed at the forehead, can help improve memory and thinking in older adults with early Alzheimer's disease or mild memory problems. About 196 participants will receive either the real light treatment or a sham (fake) tre…

This study is testing whether a culturally tailored telehealth program, where community health workers coach patients remotely, can help South Asian immigrants better control their diabetes and high blood pressure. It will compare this coaching approach to usual medical care over…

This study tested whether delivering alcohol treatment in Black churches helps more people than standard clinic care. Researchers compared how many Black adults with alcohol problems started treatment, stayed in it, and reduced their drinking in each setting. The goal was to see …

This study is testing a new coaching program to help nurses better manage high blood pressure in patients who are also living with HIV. It involves 830 adults with uncontrolled blood pressure across 30 primary health clinics in Nigeria. The goal is to see if providing nurses with…

This study compares two ways emergency departments can help people with opioid addiction. It tests whether a standard emergency visit or a longer observation stay works better to start medication treatment and connect patients to ongoing care. Researchers are measuring how many p…

This study is testing whether a diet personalized to an individual's unique gut microbiome can better control dangerous blood sugar spikes in people with early type 2 diabetes. About 300 participants are being assigned to either a standard diet, a personalized diet, or their usua…

This study is testing a new combination of three drugs to prevent a dangerous complication called graft-versus-host disease (GVHD) after a half-matched stem cell transplant for blood cancers. The trial involves 27 adults receiving a transplant from a partially matched family dono…

This study aims to see if MRI scans can help doctors better predict which heart failure patients will benefit from a special pacemaker therapy called CRT. Researchers will use MRI data and computer models to understand why some patients respond well to this treatment while others…

This study is testing a new device called Napoleon to measure the size of the stomach opening in people who have had gastric bypass surgery and regained weight. During a routine endoscopy, doctors will first estimate the opening size by eye, then measure it with the Napoleon devi…

This study tested a new, much faster type of breast MRI scan to see if it can accurately tell the difference between cancerous and non-cancerous breast tissue. It involved 264 women who were already scheduled for a standard breast MRI as part of their care. The goal is to make br…

This study tests whether a diabetes prevention program delivered through telehealth (video calls) works as well as traditional in-person sessions for older adults with prediabetes. Researchers are comparing weight loss and program attendance between 238 participants randomly assi…

This study is testing whether a personalized support program can help prevent early deaths in low-income adults. The program provides health navigation, personalized benefits, and compensation for health-related costs to help participants reduce risks from heavy drinking, heart d…

This study is testing a diet, exercise, and lifestyle program to see if it can help prevent uterine fibroids from growing back after they have been surgically removed. It will enroll 100 women who recently had fibroid surgery to see if they find the program helpful and if it impr…

This study is testing a new computer system designed to help doctors remember to order liver ultrasound scans for their patients with cirrhosis. The goal is to improve screening for liver cancer (hepatocellular carcinoma) by making it easier for doctors to place the right orders …

This study compares two approaches to help pregnant women adopt healthy lifestyles. One uses text messages and online videos, while the other involves direct support from community health workers. Researchers want to see which method is more effective at getting women to particip…

This study aimed to see if a simple behavioral reminder, based on the idea that people follow social norms, could get more patients to complete an at-home colon cancer screening test. It was planned for patients aged 45-75 at a specific New York City clinic who were due for scree…

This study aims to increase colon cancer screening rates in underserved Brooklyn communities by proactively mailing at-home stool test kits to eligible patients. The research will test whether this organized outreach, combined with support navigation, helps more people complete r…

This study is testing if adding magnesium sulfate to anesthesia during prostate surgery helps reduce pain afterward. Researchers will compare pain levels and opioid medication use between patients who receive the magnesium and those who do not. The goal is to see if this approach…

This study tests whether a parenting support program can help young children's development and mental health in Flint, Michigan following the water crisis. Researchers are working with 486 families with infants under 3 months old to provide parenting guidance and support. The pro…

This small pilot study is testing whether a medication film that dissolves under the tongue can safely and effectively stop severe 'autonomic crises' at home for adults with familial dysautonomia. The goal is to see if running a home-based treatment trial is practical and to refi…

This small pilot study is testing whether adding virtual reality to treadmill training is a practical way to help people with traumatic brain injury. Researchers want to see if this approach can improve walking, balance, and confidence while reducing the fear of falling. The stud…

This small study is testing whether a mindfulness therapy program delivered over the phone can help patients who worry a lot about pain cope better before and after spine surgery. Researchers will first adapt the program with a small group, then offer four weekly sessions to 20 p…

This study is testing a surgical technique called 'breast neurotization' to see if it can help restore nipple sensation for women who have had breast reconstruction with implants after a mastectomy. In this small trial, each participant serves as her own control: the nerve repair…

This study aims to find the best exercise intensity to help reduce anxiety. It enrolled 111 adults with anxiety disorders who don't exercise much. Participants were assigned to either a low-intensity or a flexible high-intensity exercise program for 8 weeks, using heart rate moni…

This study is testing if applying cold therapy (cryotherapy) to the hands and feet during chemotherapy can prevent nerve damage, a common and debilitating side effect. It involves 40 adults with stage III colon cancer who are starting a specific chemotherapy regimen. The goal is …

This study aimed to see if a vibration device could reduce pain during a common hair loss treatment. It planned to test the device on one side of the scalp during platelet-rich plasma (PRP) injections, while the other side received no vibration. The trial was withdrawn before any…

This small study aims to see if taking creatine, a supplement often used for muscle strength, can help improve voice quality and reduce effort in older adults. Twenty participants over 65 with voice complaints will take either creatine or a placebo pill daily while also doing voi…

This study aims to understand the brain-related causes of long COVID symptoms like memory problems, anxiety, and depression. Researchers will use advanced brain scans and blood tests on 30 people who had COVID-19 3 to 12 months ago. The goal is to see if inflammation or blood ves…

This study is testing whether sending quarterly feedback emails to heart doctors helps them follow treatment guidelines more closely for patients with heart failure or atrial fibrillation. It involves about 7,000 patients who have visited a cardiology clinic recently. The goal is…

This study aims to understand how aspirin affects blood platelets in pregnant patients at high risk for preeclampsia, a serious blood pressure disorder. Researchers will collect blood samples from about 66 patients before and during pregnancy to see if platelet changes are linked…

This study aims to understand why some people don't develop good protection after hepatitis B vaccination. Researchers will compare two different hepatitis B vaccines in 101 adults to learn how the immune system responds. The findings could help design better vaccines in the futu…

This study aims to understand why some women experience chest pain and heart stress despite having clear major heart arteries. Researchers are examining 206 women with stable chest pain to see if tiny blood vessel problems, platelet activity, or inflammation might be the cause. T…

This study is exploring if a continuous glucose monitor (CGM) can help older adults with type 2 diabetes and mild memory problems manage their condition better when they share the data with a family member or caregiver. For two weeks, 10 older adults and their 10 helpers will use…

This is a small pilot study to see if a community education session can help people learn more about skin cancer and check their skin more often. About 35 adults in Bensonhurst, Brooklyn will attend a session led by a community health worker. Researchers will use surveys to track…

This study is testing whether a simple hearing program can work in regular doctor's offices for older adults who may not have easy access to hearing care. Researchers will screen 120 people for hearing loss during their check-up. They will then compare two approaches: giving quic…

This large, long-term study aims to understand why some children and young adults develop lasting health problems after a COVID-19 infection, known as Long COVID or PASC. It will follow over 15,000 participants, both with and without prior infection, to identify risk factors and …

This study is testing if a special type of MRI scan can better measure how head and neck cancer responds to chemotherapy and radiation. Researchers want to see if this scan, which looks at how water moves inside tumor cells, can provide an early and accurate picture of whether th…

This study aims to understand if stimulating a small nerve in the ear causes a pupil dilation response. It involves 30 adults who are already scheduled for cochlear implant or vagal nerve stimulator surgery. Researchers will measure changes in pupil size during the procedure to l…

This study is testing new MRI software designed to take clearer pictures of the heart while you breathe. Researchers want to see if this method provides useful information about how breathing affects heart function and if it's practical for doctors to use. They will enroll about …

This study aims to understand how well a lower-dose mpox vaccine works and how safe it is for people living with HIV, compared to people without HIV and to the standard vaccine dose. Researchers will measure immune responses and track side effects in 174 participants who have rec…

This small study is testing whether a supplement called N-acetylcysteine (NAC) affects the body's stress and inflammation levels differently in men and women with obstructive sleep apnea. Participants already using standard sleep apnea therapy will take either NAC or a placebo fo…

This study is investigating whether the amount of saturated fat in a woman's breast tissue is linked to breast cancer. Researchers are using a new, non-invasive MRI technique to measure fat types in the breasts of 190 postmenopausal women. The goal is to see if this measurement c…

This study aims to understand why some people have heart attacks even when their main heart arteries don't show significant blockages. Researchers will use two advanced imaging techniques—one to examine artery walls and another to look at heart muscle damage—in 15 patients who've…