Nyu Langone Health

This pilot study is testing whether combining a modified Atkins diet (low-carb, high-protein) with a 12-week fitness program can improve quality of life and physical function in 15 people with malignant glioma. Participants will follow the diet and attend two supervised exercise …

This study tests different medication and counseling combinations to improve how long people stay in treatment for opioid use disorder and whether they can safely stop medication without relapsing. Over 1,500 participants choose either buprenorphine or naltrexone and are randomly…

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests a program called PACE that combines nurse support, remote blood pressure monitoring, and help with social needs (like housing or food) to improve blood pressure control in Black patients. About 500 adults with uncontrolled high blood pressure will take part acros…

This early-phase study tests whether adding the drug azeliragon to radiation therapy is safe for people whose cancer has spread to the lining of the brain and spinal cord. About 21 adults with solid tumors or aggressive brain cancers will receive the combination. The main goal is…

This study tests whether a collaborative care model—where a nurse care manager works with your primary care doctor and an addiction specialist—can help adults reduce their use of opioids, stimulants (like cocaine or meth), and heavy drinking. About 300 patients from primary care …

This pilot study tests whether giving packed red blood cells during in-hospital cardiac arrest can help deliver oxygen to the brain and other vital organs. Researchers plan to enroll 30 adults who have been in cardiac arrest for at least 10 minutes, comparing blood transfusions t…

This early-phase trial tests whether adding two immune-boosting drugs (canakinumab and tislelizumab) to standard chemotherapy can safely shrink pancreatic tumors before surgery. Nine adults with resectable or borderline resectable pancreatic cancer will receive the combination. T…

This study tests a precise type of radiation called VMAT for people whose cancer has spread to the lining of the brain and spine (leptomeningeal metastasis). The goal is to see if this approach can delay cancer growth in the central nervous system better than older radiation meth…

This study tests a drug called Lutathera, which delivers radiation directly to tumor cells, in 32 adults with a type of brain tumor called meningioma that is growing or hard to treat. Participants receive four doses of the drug through an IV, 8 weeks apart. The main goal is to se…

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab + nivolumab) can reduce severe immune-related side effects in people with advanced melanoma that cannot be removed by surgery. About 71 participants will receive the three-drug combination during an…

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This study compares two ways to treat alcohol use disorder in Black adults: a computer-based therapy offered in a Black church versus traditional care at a specialty clinic. Researchers want to see which setting gets more people to start and stay in treatment, and leads to more d…

This study tests a new combination of three drugs (cyclophosphamide, abatacept, and tacrolimus) given at lower doses to prevent graft-versus-host disease (GVHD) in 27 adults receiving a stem cell transplant from a half-matched donor. GVHD is a serious condition where donor cells …

This study tests whether a structured diet, exercise, and lifestyle program can help prevent uterine fibroids from returning after surgery. Researchers will follow 100 women aged 18-50 who recently had fibroids removed and are currently fibroid-free. The goal is to see if the pro…

This study compares standard emergency department care to an extended observation period for people with opioid use disorder. Participants are randomly assigned to either leave after a regular ED visit or stay longer in an observation unit to receive their first dose of buprenorp…

This study tests whether a culturally tailored telehealth coaching program led by community health workers can help South Asian adults with type 2 diabetes and high blood pressure get their blood pressure under control. About 450 participants will either receive the coaching or u…

This phase II trial tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy and radiation can help people with muscle-invasive bladder cancer avoid bladder removal. The study enrolls 60 patients who cannot or choose not to have surgery. The m…

This study aims to improve early detection of lung cancer in Asian women who have never smoked, a group at higher risk but not covered by standard screening guidelines. Participants receive up to three low-dose CT scans and a blood test designed to spot early signs of cancer. Res…

This study aims to make MRI scans clearer for people with heart arrhythmia (irregular heartbeat). Researchers will test two special imaging methods on 135 participants—105 with arrhythmia and 30 healthy volunteers—to see if they reduce blurry images caused by the irregular rhythm…

This study looks at the best timing for a special PET scan (rhPSMA-7.3) to detect prostate cancer that has come back after prostate removal surgery. Men with a rising PSA level will get one or two scans to see when the cancer is most visible. The goal is to find the cancer early …

This study tests a new, 15-minute MRI scan that measures the types of fat in breast tissue. Researchers want to see if women with breast cancer have more saturated fat in their breasts than women with benign lumps. About 190 postmenopausal women will get the extra scan during the…

This study uses advanced PET and MRI scans to look for brain inflammation and blood vessel problems in 30 people with long COVID who have brain fog, anxiety, or depression. The goal is to develop better ways to diagnose these lingering symptoms, not to test a treatment. Participa…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps by measuring how contrast dye moves into the tissue. About 264 women already scheduled for a standard breast M…

This study looks at whether helping communities switch to cleaner cookstoves can lower indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part. Some families get extra support to use the new stoves, while others just receive informat…

This study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be r…

This study looks at whether a diabetes prevention program delivered via telehealth works as well as the same program done in person for adults aged 65 and older with prediabetes. About 238 participants will be randomly assigned to either a telehealth or in-person group, and resea…

This study tests whether sending a letter, a home stool test kit (FIT), and follow-up phone calls can increase colorectal cancer screening among 3,000 patients aged 45-75 at community health centers in Brooklyn. Those who respond get help completing the test or scheduling a colon…

This study tests a remote program called StEP:Prenatal that uses a mobile app to coach pregnant women on healthy eating, physical activity, and stress reduction. About 276 pregnant women in their first trimester will either receive the program or standard care. The goal is to see…

This study tests whether giving the drug ketamine during or right after mastectomy surgery can lower the chance of developing long-lasting pain. About 765 women having breast cancer surgery will be randomly assigned to receive a low-dose ketamine drip during surgery, a single ket…

This study tests whether a cream made with caffeine can help prevent skin hardening and other complications in breast cancer patients who need radiation after mastectomy with tissue expander reconstruction. About 60 participants will use either the caffeine cream or a placebo cre…

This study tests if a gentle, non-invasive nerve stimulation device can help manage symptoms of multiple sclerosis (MS), like fatigue and pain. Thirty women with MS will use the device at home for a few weeks. The goal is to see if it's practical and if it reduces symptom burden,…

This study aimed to see if adding a hyaluronic acid-based vaginal moisturizer to standard vaginal estrogen therapy provides extra relief for menopause-related vaginal symptoms. It planned to enroll postmenopausal women aged 45 and older who had not used these treatments recently.…

This study looks at whether special high-dissolving foods can improve feeding quality of life for children aged 6 months to 18 years after craniofacial surgery. Half of the 160 participants will receive these foods after surgery, while the other half will follow standard care. Re…

This study tests a medicated film placed under the tongue to quickly ease severe episodes (autonomic crises) in people with familial dysautonomia. The film contains dexmedetomidine, a drug that calms the body's stress response. Researchers will check if it reduces symptoms like h…

This study tests whether injecting an anesthetic near certain neck nerves (stellate ganglion block) can reduce PTSD symptoms by calming overactive stress responses. About 79 adults with chronic PTSD will receive either the anesthetic or a placebo (saline) injection. Researchers w…

This pilot study tests whether low-intensity focused ultrasound, guided by MRI, can safely and feasibly target a deep brain region (the thalamus) in people with treatment-resistant schizophrenia. Only 3 participants were planned, and the study is currently suspended. The goal is …

This study looks at whether wearing a splint and going to formal physical therapy are necessary after surgery for a broken wrist. About 230 adults with a specific type of wrist fracture will be followed to see if early movement (no splint) leads to better outcomes and lower costs…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study tests whether taking creatine supplements daily for 10 weeks can improve voice quality in people aged 65 and older who have age-related voice changes (presbyphonia). Twenty participants will be randomly assigned to receive either creatine or a placebo. Researchers will…

This study tests whether a device that guides slow breathing can improve heart rate variability and quality of life in people who have had takotsubo syndrome (also known as broken heart syndrome). Ten patients with a history of takotsubo and ten healthy volunteers will use the RE…

This study tests whether giving magnesium sulfate during prostate surgery can lower pain and reduce the need for strong painkillers. About 68 adults having robotic prostate surgery will either receive magnesium or not, as part of their standard anesthesia. Researchers will compar…

This small pilot study is testing whether a medicated film placed under the tongue can safely and effectively stop autonomic crises in people with familial dysautonomia at home. Five adults who have had previous crises and tolerated a similar IV drug are enrolled. The goal is to …

This study tests whether coaching for people with dementia and their caregivers can improve care and reduce future emergency room visits. About 19,200 participants aged 66 and older with Alzheimer's or related dementias will receive different combinations of support after an ER v…

This study tests whether playing a low-frequency sound during deep sleep can reduce seizure activity in people with epilepsy. About 36 adults will use a smartphone app and headphones at home for two months. The goal is to see if this simple, non-invasive method is feasible and ef…

This study tests whether a nerve reconstruction procedure can restore nipple sensation in women undergoing implant-based breast reconstruction after mastectomy. Six women having bilateral reconstruction will receive the nerve graft on one breast only, acting as their own control.…

This study was designed to test whether a vibrating device called Buzzy can reduce pain during platelet-rich plasma (PRP) injections for hair loss. Researchers planned to treat half of each participant's scalp with the vibration and the other half without, then compare pain score…

This study compares a newer surgical approach that spares the rotator cuff to the traditional method for total shoulder replacement in 108 adults with arthritis. The goal is to see which approach leads to better shoulder function and recovery. Participants will be followed for at…

This small pilot study is testing whether walking on a treadmill with virtual reality feedback can help people with traumatic brain injury improve their balance, reduce fear of falling, and lower fall risk. The study involves 20 adults aged 18 to 90 who have had a TBI at least on…

This study explores whether a few phone-based mindfulness sessions before spine surgery can help people who worry a lot about pain. Researchers will first adapt the therapy with a small group, then test it in 20 people scheduled for surgery. The goal is to see if it's practical a…

This study tests if a shorter course of radiation (3 doses over 5 days) is as safe and works as well as the standard 5-dose schedule for women with early-stage breast cancer. About 284 post-menopausal women with small, low-risk tumors took part. The main goal is to see if the sho…

This study tests a new, non-invasive treatment called transcranial photobiomodulation (t-PBM) for people with mild cognitive impairment or early Alzheimer's disease. 196 participants aged 65-85 will receive either real or fake light therapy to the forehead for 8 weeks. The goal i…

This early-phase study looks at whether older adults (65+) with type 2 diabetes and mild cognitive impairment can better manage their blood sugar by sharing continuous glucose monitor data with a care partner via a mobile app. Fourteen participants and their care partners will us…

This study looks at whether a rapid HIV antibody test can detect when the virus rebounds in people taking antiretroviral therapy (ART). Researchers will analyze stored blood samples from 6100 HIV-positive individuals in the US and sub-Saharan Africa. They will compare antibody le…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study examines tissue from people who died after a COVID-19 infection to understand why some develop Long COVID. Researchers will look for signs of inflammation, scarring, blood clots, and tissue death in the body. The goal is to learn more about the long-term effects of the…

This pilot study is testing a program that gives Chinese American families in New York City monthly boxes of whole grains, legumes, and produce, along with recipes and children's books. The goal is to see if this culturally tailored program can improve diet and family togethernes…

This study looks at whether offering genetic testing to family members of people with hereditary breast and ovarian cancer syndrome helps more relatives learn about their own cancer risk. Researchers will follow 118 participants and their relatives to see how many choose to get t…

This study uses special MRI scans to look at kidney tumors in 39 people scheduled for surgery. The goal is to see if these scans can tell whether a tumor is cancerous and what type it is, as well as predict how well the kidney will work after part of it is removed. No new treatme…

This study looks at 50 adults hospitalized with acute decompensated heart failure who need intravenous diuretics (water pills). Researchers want to see if a non-invasive monitor called the Starling System can accurately measure changes in heart function as fluid is removed. The g…

This study looks at whether a package of tools and support can help staff and tenants in 20 supportive housing buildings in New York adopt proven overdose prevention practices. Researchers will survey tenants and staff, observe what happens, and check health records to see if the…

This study looks at 200 male FDNY rescue workers who were exposed to dust and toxins after the World Trade Center attacks. Many developed acid reflux, which can lead to Barrett's esophagus and even cancer. Researchers will use simple, noninvasive tests like saliva samples and que…

This small study tests whether the supplement N-acetylcysteine (NAC) can reduce oxidative stress and inflammation in people with obstructive sleep apnea who are already using standard PAP therapy. Researchers want to see if the effects differ between men and women. The study invo…

This study looks at how age-related sleep changes and sleep apnea might increase the risk of Alzheimer's disease. Researchers will use brain scans and overnight sleep tests in 158 healthy adults aged 55-75 to measure amyloid buildup and sleep patterns over two years. The goal is …

This study looks at 450 people who had a heart attack but no major blockages in their heart arteries (called MINOCA). Using advanced imaging, researchers aim to find the real cause, such as plaque disruption or artery tears. Participants are followed every 6 months for up to 10 y…

This study tests a new technique that lets a cochlear implant stimulate the entire cochlea without needing a longer electrode. The goal is to see if this improves speech understanding and sound quality for people with hearing loss. About 40 adults who already qualify for a cochle…

This study tests whether an automatic reminder in the electronic health record can increase the number of cirrhosis patients who get screened for liver cancer (hepatocellular carcinoma). The reminder prompts doctors to order a liver ultrasound when they see a patient with cirrhos…

This study aimed to see if giving patients a simple pamphlet with a social norm message (showing how their clinic's screening rate compares to others) could increase the number of people completing a take-home colorectal cancer screening test (FIT). The plan was to enroll adults …

This study looks at two ways to give lifestyle advice to pregnant women: one using text messages and online videos, and the other using community health workers for group or individual sessions. Researchers want to see which method is more widely adopted and followed. About 1,050…

This study looks at how stimulating a nerve in the ear affects pupil size during cochlear implant surgery. Researchers will measure pupil dilation in 30 adults to learn more about the vagus nerve's role in hearing. The goal is to gather knowledge, not to treat hearing loss direct…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This study tests whether a special type of MRI, called diffusion MRI, can accurately measure how head and neck tumors change during chemotherapy and radiation. Researchers will scan 16 patients before and during treatment to see if the MRI can predict whether the cancer shrinks o…

This study was designed to see if adding an internal brace during ACL reconstruction surgery helps the knee heal better. It planned to compare two groups of people having ACL surgery using a quadriceps tendon graft. However, the study was withdrawn before enrolling any participan…

This study tests a hearing program for older adults who don't have easy access to hearing care. During a primary care visit, participants are screened for hearing loss and then randomly assigned to either get counseling on affordable listening devices or be referred to standard a…

This study tests newer ways to perform heart MRI that capture how the heart and lungs interact during breathing. Researchers will compare these methods to standard scans in 100 people with heart disease. The goal is to see if the new software produces clearer images and is practi…

This large observational study is following about 15,000 children and young adults (ages 0-25) across the U.S. to learn more about long COVID, also called PASC. Researchers will track symptoms, infections, and health over time using surveys and medical records. The goal is to ide…

This study tests a new device called Napoleon, a tiny catheter with a ruler, to measure the size of the stomach-connection opening in people who have regained weight after gastric bypass surgery. Doctors will compare measurements taken with the device to their usual visual estima…

This study tests whether sending cardiologists regular emails about quality goals helps them prescribe recommended medications for heart failure and atrial fibrillation. Researchers will track prescribing rates for 7,000 patients. The goal is to see if simple feedback can improve…

This study looks at why some people do not develop enough protection after getting the hepatitis B vaccine. Researchers will compare the standard vaccine with a newer one that seems to work better. By studying the immune responses of 101 adults, they hope to find clues that could…

This study looks at whether offering parenting support to all families with very young children in Flint, Michigan can help kids' development and mental health after the water crisis. About 486 families with babies up to 3 months old took part. Researchers measured parenting stre…

This study looks at why some women with chest pain or signs of heart disease have normal-looking large arteries but still have problems with tiny blood vessels in the heart. Researchers will measure platelet activity and inflammation during a heart catheterization to see if these…

This study explores whether MRI scans can help doctors predict which heart failure patients will respond well to a special pacemaker treatment called cardiac resynchronization therapy (CRT). Researchers will analyze MRI images from 110 adults scheduled for CRT and use computer mo…

This study looks at how well the mpox vaccine works and how safe it is in people with HIV compared to those without HIV. About 174 adults who either recently got the mpox vaccine or had a recent mpox infection will take part. The goal is to fill important knowledge gaps and help …

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This pilot study tests whether a community-based educational seminar can improve knowledge about melanoma and skin cancer. About 45 adults in Brooklyn will attend a session led by a community health worker and complete surveys over 12 months. The goal is to see if people learn mo…

This study looks at 15 people who had a heart attack but whose arteries were not blocked. Researchers use two types of imaging—one inside the artery and one MRI of the heart—to find hidden plaque or damage that might explain the attack. The goal is to better understand these puzz…