Nyu Langone Health

This study tests a radioactive drug called Rhenium-186 NanoLiposome (REYOBIQ) given directly into the brain's fluid space, combined with whole brain or proton radiation. It is for people with leptomeningeal metastases, where cancer has spread to the lining of the brain and spinal…

This study will adapt a community health worker-led program to include mental health and digital tools for South Asians with type 2 diabetes who are at risk for depression. Researchers will test whether the program is feasible and acceptable to participants. The study involves 10…

This study tests whether the drug emapalumab can prevent severe side effects (cytokine release syndrome and nerve-related toxicity) in people with lymphoma or multiple myeloma receiving bispecific antibody therapy. About 60 adults will take emapalumab before their cancer treatmen…

This early-stage trial tests whether using a special MRI-guided radiation machine (MR-Linac) can safely deliver higher, more targeted radiation doses to aggressive brain tumors (high-grade glioma). Twenty newly diagnosed patients will receive radiation twice a week for three week…

This study tests a new approach for people with a certain type of throat cancer that is not low-risk. Participants first receive a combination of chemotherapy, immunotherapy, and a special type of radiation called lattice radiotherapy. Then, based on how much the tumor shrinks, t…

This study compares a telerehabilitation system called Band Connect to standard in-person physical therapy for people recovering from rotator cuff repair surgery. The Band Connect uses smart handles and resistance bands that connect to a phone app to guide exercises and track pro…

This early-phase study tests a new type of radiation (lattice radiotherapy) given with chemotherapy and immunotherapy before surgery for oral cavity cancer. About 30 adults with advanced but removable tumors will receive different radiation doses to find the safest level. The goa…

This study tests a program that combines online diabetes education videos with help connecting to social services for low-income Chinese and Latino/a immigrants with type 2 diabetes. The goal is to improve blood sugar control and see if people find the program useful and easy to …

This study tests whether a personalized diet plan, guided by a continuous glucose monitor (CGM), can help Chinese and Vietnamese Americans with type 2 diabetes better control their blood sugar. 120 participants will either receive the adaptive diet program or standard care for 12…

This study will test a new imaging tool called the ATEC IntraOperative Alignment (IOA) Platform in 40 adults undergoing spinal deformity surgery. The tool helps surgeons see and measure spinal alignment during the operation, potentially allowing for more precise corrections. Rese…

This study tests a fast genetic test (UR-ddPCR) that checks for IDH1-mutant tumor cells in brain tissue during surgery. If the test finds leftover cancer, the surgeon can remove more tissue right away. The trial will enroll 105 adults with newly diagnosed IDH-mutant glioma at NYU…

This pilot study will test a program called INSPIRE, designed to reduce stigma and increase HIV testing among Chinese immigrant women who work in massage parlors in Queens, NYC. The program involves four one-on-one conversations with a peer advocate over six weeks, plus weekly te…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This pilot study tests a communication skills training program called Starting the Conversation for prostate cancer patients who are bothered by sexual problems. About 100 men will either receive the training or a general health education program. The goal is to see if the traini…

This study compares three different walking training programs for people recovering from a stroke. Twenty participants will be randomly assigned to moderate-intensity walking, high-intensity walking, or high step-count walking during their inpatient rehab. The goal is to see whic…

This study tests whether applying a mix of local anesthetics and blood-clotting drugs directly into surgical wounds during hand surgery can reduce pain and the need for opioid painkillers afterward. Forty adults having elective hand surgery will be randomly assigned to one of fou…

This early-stage study tests whether a single 25 mg dose of psilocybin can help people who still feel emotionally flat or uninterested in things despite taking antidepressants. About 90 adults aged 18-65 will receive either psilocybin or a placebo, and researchers will use brain …

This study tests whether an implanted device called Altius can reduce persistent pain in people who have lost a leg and still hurt despite prior nerve surgery. About 32 adults will get the device and report changes in pain, mood, and how often they use their prosthetic limb. The …

This early study tests whether a gel called Barrigel can stay unfrozen and protect the rectum during prostate cancer cryoablation (freezing treatment). About 20 men with localized or recurrent prostate cancer will receive the gel before the procedure. The main goal is to see if t…

This study will compare two types of lasers used to break up kidney stones during a procedure called ureteroscopy. About 70 adults with a single kidney stone or multiple stones totaling 7-20 mm will be randomly assigned to receive either a pulsed Thulium:YAG laser or a pulse-modu…

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This early study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe irritable bowel syndrome (IBS). Ten adults with hard-to-treat IBS will receive either a high dose of psilocybin or a placebo (niacin) during…

This study explores how visual impairment affects movement and daily activities, and tests a wearable system called VIS4ION that provides audio and touch cues to help users navigate. Researchers will enroll 150 adults with visual impairment and healthy controls to see if the devi…

This study tests a gel called PuraStat that is applied inside the prostate after a water-jet surgery (Aquablation) for enlarged prostate. The goal is to see if it reduces bleeding enough for men to go home the same day. Twenty-five men will take part in this early pilot study.

This Phase 2 pilot study will test whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with speech therapy can improve fluency and reduce struggle in 25 adults who stutter. Researchers will measure changes in stuttering severity and brain …

This pilot study will test whether a weighted blanket can help reduce anxiety and pain in people recovering from total knee replacement surgery. Thirty adults scheduled for knee replacement at NYU Langone will be randomly assigned to receive either a weighted blanket or a regular…

This pilot study will test whether virtual Reiki therapy can reduce pain and improve well-being in people with lupus. Twenty adults with lupus will receive 20-minute Reiki sessions once a week for 8 weeks, delivered remotely by a certified practitioner. Researchers will measure c…

This study tests a program called SUFICS-PACT for prostate cancer survivors who have sexual or urinary problems after treatment. The program includes screening, counseling from mental health professionals, and close follow-up. About 200 participants will be randomly assigned to r…

This study looks at how Black and Hispanic adults in the U.S. feel about online information on prostate cancer. Participants will view a video or text post about the disease and then fill out a short survey. The goal is to understand trust and emotional reactions to online health…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This study looks at whether it is safe to give patients their own salvaged red blood cells back during surgery for pancreatic cancer. About 40 adults will take part, and researchers will track infections and other complications within the first week after surgery. The goal is to …

This study will examine 250 adults with chest pain but no major blockages in their heart arteries (a condition called INOCA). Researchers will collect cells from the heart's blood vessels during a standard angiogram and track symptoms, activity, and function over one year using q…

This study looks at how young children with neurofibromatosis type 1 (NF1) walk, to see if simple walking tests can help doctors spot and predict movement problems early. Researchers will measure walking speed and other skills in 56 children under 6 years old. The goal is to crea…

This study looks at whether a special training program can help supportive housing agencies in New York and New Jersey use proven methods to prevent overdoses and improve tenant health. About 24 agencies and 2940 people will take part. The goal is to see how well agencies adopt t…

This pilot study will check if it's possible to collect health information like cholesterol, blood pressure, and diet quality from people taking part in a community food program in Brooklyn. The program gives culturally appropriate fresh produce weekly for 20 weeks. Researchers w…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides personalized advice on side effects and dose adjustments. The study is in its early stages, with only 16 participants, and is…

This study looks at whether showing people a live video of their swallowing pressure helps them perform swallowing exercises better. Fifty healthy adults aged 18-40 will swallow with a thin pressure-sensing tube in their nose. Researchers will compare swallowing strength and timi…

This study will follow over 5,000 adults with Long COVID for two years each to understand how the condition changes over time, who recovers, and what new illnesses may develop. Researchers will focus on brain fog, heart and lung problems, and chronic fatigue. No drugs or treatmen…

This pilot study will test whether a potassium-containing salt substitute is safe for people with end-stage kidney disease on hemodialysis. Twenty participants will use the salt substitute for 16 days and regular table salt for 16 days, with a break in between. Researchers will m…

This pilot study will test a new 3D-printed mechanical balancer in 50 people undergoing total knee replacement. The device measures force differences on the inner and outer sides of the knee during surgery to help surgeons see if the knee is balanced. The tool is used alongside s…

This study looks at how overdose prevention centers (OPCs) in New York City impact the risk of fatal and non-fatal overdoses, as well as mental health crises, among adults who use multiple drugs. Researchers will track 500 people who use OPCs or syringe services to see if these c…

This study tests a computer tool that gently reminds doctors when they are about to order a CT scan for a possible pulmonary embolism (a blood clot in the lung) against clinical guidelines. The tool only appears when the order may not be needed, giving doctors a chance to reconsi…

This study will compare infection rates in 200 children having their tonsils out, using either a head-only drape or a full-body drape. The goal is to see if using less draping material is safe and can reduce waste and costs. Researchers will also measure how much waste is produce…

This study tests a new tool called Communication Compass that gives personalized feedback to medical residents on how they educate and counsel patients. The goal is to improve their communication skills. The study will involve 120 internal medicine residents at NYU Langone Health…