Ketamine may ease chronic pain after mastectomy, major trial underway

NCT ID NCT05037123

Ongoing Symptom relief Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the drug ketamine during or right after mastectomy surgery can lower the chance of developing long-lasting pain. About 765 women having breast cancer surgery will be randomly assigned to receive a low-dose ketamine drip during surgery, a single ketamine shot after surgery, or a placebo (salt water). The goal is to see if either ketamine approach reduces pain severity and interference with daily life three months later.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC POSTSURGICAL PAIN

Contacts and locations

Locations

Brigham and Women's Hospital - Harvard University

Chestnut Hill, Massachusetts, 02467, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Montefiore Medical Center - Albert Einstein College of Medicine

The Bronx, New York, 10467, United States
NYU Langone Health (Tisch Hospital, Kimmel Pavilion)

New York, New York, 10016, United States
New York Presbyterian Columbia University Irving Medical Center

New York, New York, 10032, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of Arkansas

Little Rock, Arkansas, 72205, United States
University of Pittsburgh - Magee Women's Hospital

Pittsburgh, Pennsylvania, 15213, United States
University of Texas - MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Texas - Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
Washington University at St. Louis Medical Center

St Louis, Missouri, 63110, United States

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