ULCERATIVE COLITIS

This study tests a new oral medication called BRS201 for adults with severe ulcerative colitis who haven't gotten better with standard treatments. Over 12 weeks, 20 participants will take the drug twice daily and attend 8 clinic visits for blood, stool, and urine tests. The goal …

This study tests whether transplanting healthy stool bacteria (fecal microbiota transplantation) can help control ulcerative colitis, a chronic gut disease. About 85 adults with active colitis will receive either the transplant or a placebo. The main goal is to see if a larger tr…

This program provides early access to upadacitinib for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis. It is for patients who have no other suitable treatments and cannot join a clinical trial. A doctor must decide if the potenti…

This study tests whether a special form of vitamin B3 (nicotinamide) can help people with mild to moderate ulcerative colitis. About 459 adults will take either a low dose, high dose, or placebo pill for several weeks. The goal is to see if it reduces gut inflammation and improve…

This study tests a new drug called RO7837195 for people with moderate to severe ulcerative colitis who haven't gotten better with other treatments. About 224 participants will receive either the drug or a placebo for 12 weeks to see if it can bring the disease under control. The …

This study looks at how well vedolizumab works for people with moderate to severe ulcerative colitis or Crohn's disease. About 400 adults will receive the drug, first as an IV infusion and then as a shot under the skin, for about a year. The main goal is to see if symptoms like d…

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study tests the drug risankizumab in children aged 2 to 18 with moderate to severe ulcerative colitis, a disease that causes inflammation and bleeding in the colon. The trial has three parts: first, all children receive the drug intravenously for 12 weeks; then, they are ran…

This study follows 400 adults with moderate to severe ulcerative colitis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will check how well the drug controls symptoms like diarrhea and bleeding, especially in the first 8 weeks, and track results for up to 2…

This study tests whether giving several fecal transplants (instead of just one) works better to clear repeat C. diff infections in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusions of healthy donor…

This study tests a daily medication called filgotinib (200 mg) in about 94 Korean adults with moderate-to-severe ulcerative colitis. The main goal is to see if it can bring the disease into remission (no active symptoms) by week 10 or 22. Participants take the pill once daily and…

This study tests whether combining two drugs, vedolizumab and tofacitinib, can help adults with moderate to severe ulcerative colitis achieve remission. Participants receive both drugs for 8 weeks, then those who respond continue on vedolizumab alone for 44 weeks. The goal is to …

This study follows about 80 Chinese adults with moderate-to-severe ulcerative colitis who are already being prescribed upadacitinib by their doctor. Researchers will track how well the drug controls symptoms like bloody diarrhea over one year, using only routine clinic visit data…

This study tests a new drug called duvakitug for people with moderate to severe ulcerative colitis, a chronic bowel disease. About 980 adults will receive either the drug or a placebo for up to 12 weeks to see if it can safely help control symptoms and reduce inflammation. The go…

This study tests whether adding fermented foods to the diet can reduce inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. About 21 adults with confirmed UC and active symptoms will eat fermented foods and be monitored for changes in a sto…

This study tests whether taking freeze-dried fecal transplant capsules (PRIM-DJ2727) can help adults with ulcerative colitis stay in remission and avoid flare-ups. About 58 participants will take the capsules or a placebo for 12 weeks alongside their usual treatment. The goal is …

This study is testing whether a remote monitoring app can help people with active inflammatory bowel disease (Crohn's or ulcerative colitis) spend more time in remission. About 290 adults whose disease is flaring will use the app to track symptoms and health data. The goal is to …

This study tests a new medicine called BI 3032950 in 80 adults with moderate to severe ulcerative colitis who haven't responded to other treatments. The medicine is first given through a vein every 4 weeks, then as a shot under the skin for up to 2 years. Doctors will check if sy…

This study tests a new drug called eltrekibart, given alone or with another drug (mirikizumab), in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if the treatment can reduce symptoms and help the colon heal. Participants must have tried other treatments…

This study follows about 200 adults in Japan with moderate to severe ulcerative colitis who are prescribed risankizumab as part of their normal care. Researchers will track how well the drug controls disease symptoms like stool frequency and rectal bleeding over up to 156 weeks. …

This study tests a new medicine called SAR442970 for people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. About 99 adults will receive either the drug or a placebo to see if it can help bring the disease under control. Th…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study looks at whether a weight loss procedure called Endoscopic Sleeve Gastroplasty (ESG) is safe and effective for people with ulcerative colitis who are obese and need colon removal surgery. About 12 participants will be followed to see how much weight they lose and if th…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can stop symptoms like rectal bleeding and frequent stools, and…

This program provides children and teenagers with moderate to severe ulcerative colitis or Crohn's disease continued access to vedolizumab, a medication given through a vein, after they finish a related study. It is for those who still benefit from the treatment and have no good …

This study looks at how children and teenagers with moderate to severe ulcerative colitis or Crohn's disease process a drug called vedolizumab when given as a shot under the skin. About 70 participants who already responded to vedolizumab given through a vein will receive the sho…

This study looks at the long-term safety of a drug called vedolizumab given as a shot under the skin to children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who did well on the drug in an earlier study will keep getting it, while those who didn…

This study is testing an extended-release form of budesonide, a steroid, in children aged 5 to 17 with mild to moderate ulcerative colitis. The goal is to see if the drug can safely help kids achieve remission, meaning less bleeding and more normal bowel habits. Participants will…

This study tests an investigational drug called duvakitug in people with moderate-to-severe ulcerative colitis who have already responded to treatment. The goal is to see if duvakitug can help maintain remission better than a placebo over 40 weeks, with an optional long-term exte…

This study tests whether long-acting antibodies can help people with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. About 645 adults will receive the antibodies through an IV infusion followed by regular shots under the skin. The goal is to reduce gu…

This study tests an experimental drug called MK-8690 for people with moderate to severe ulcerative colitis, a condition causing inflammation and sores in the colon. About 100 adults will receive either the drug or a placebo to see if it can bring the disease into remission—meanin…

This study tests whether a diet rich in anti-inflammatory American foods (like grilled meats, salmon, oatmeal, and avocado) can help control ulcerative colitis and lead to disease remission. About 122 American adults with mild to moderate UC will follow the diet, and researchers …

This study tests a new drug called ISM5411 in 80 adults with active ulcerative colitis. The goal is to see if it is safe and helps control the disease. Participants will receive either the drug or a placebo, and researchers will monitor side effects and how well the drug works.

This study looks at whether taking prebiotics (a type of fiber) can improve gut health and reduce symptoms in people with ulcerative colitis, a form of inflammatory bowel disease. About 70 adults with active symptoms will take prebiotics for 8 weeks. Researchers will track change…

This study is testing whether butyrate enemas can help control ulcerative colitis in Hispanic children aged 7 to 21 with mild-to-moderate disease. Butyrate is a natural substance made by gut bacteria that may reduce inflammation. The goal is to see if it can lower disease activit…

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an UC treatment) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. About 350 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide for u…

This study tests whether two types of fibre supplements—acacia gum and microcrystalline cellulose—can reduce gut inflammation in people with ulcerative colitis. About 69 participants will add one of the fibres or a placebo to their daily diet for 6 weeks. Researchers will measure…

This study tests whether adding a new drug (LY4268989) to an existing treatment (mirikizumab) helps more people with moderate-to-severe ulcerative colitis reach remission compared to mirikizumab alone. About 252 adults will take part for up to 2 years. The goal is to see if the c…

This study tests a once-daily food supplement designed to change gut bacteria in people with mild-to-moderate ulcerative colitis. About 162 adults will take either the supplement or a placebo for 24 weeks, alongside their usual care. The goal is to see if the supplement helps ach…

This study tests a drug called filgotinib in children aged 8 to 18 with moderate to severe ulcerative colitis, a chronic bowel disease. About 80 participants will take the drug daily for up to 22 weeks to see if it can control inflammation and improve symptoms like diarrhea and b…

This study tests whether rupatadine, an allergy medicine, can safely reduce inflammation and symptoms in people with mild-to-moderate ulcerative colitis. About 60 adults will take the drug and be monitored for changes in their condition. The goal is to see if this existing drug c…

This study tests an experimental drug called tilpisertib fosmecarbil (GS-5290) in 176 adults with moderate to severe ulcerative colitis. Participants will receive either the drug or a placebo for 12 weeks to see if it improves symptoms like diarrhea, bleeding, and bowel inflammat…

This study is testing whether adding the deworming drug mebendazole to standard mesalamine therapy can safely improve symptoms in people with mild-to-moderate ulcerative colitis. About 46 adults will take mebendazole alongside their usual medication, and researchers will track ch…

This study tests whether swallowing frozen capsules containing filtered or whole donor stool can safely bring ulcerative colitis into remission. About 129 adults with mild-to-moderate active disease who have not responded to standard treatments will take the capsules or a placebo…

This study looks at how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and teenagers with moderate-to-severe ulcerative colitis or Crohn's disease. About 150 participants who have already been in earlier studies will continue treatme…

This study looks at the long-term safety of the drug vedolizumab in children with ulcerative colitis or Crohn's disease. It is for kids who already completed a previous study on this drug. Researchers will track side effects and major bowel-related events like hospitalizations or…

This study follows about 200 adults with moderate to severe ulcerative colitis who are prescribed risankizumab by their doctors. Researchers will track how well the drug controls symptoms like bleeding and diarrhea over 52 weeks. The goal is to see how effective and safe the trea…

This study tests an oral medication called etrasimod in 36 adolescents (ages 12-17) with moderate to severe ulcerative colitis, a chronic gut condition. The goal is to see if the drug can safely reduce inflammation and help achieve remission over 52 weeks, with an option to conti…

This early-stage study is testing a probiotic called R-3750 in 36 adults with mild to moderate ulcerative colitis. The main goal is to see if the probiotic is safe and well-tolerated. Participants will take the probiotic by mouth and report their symptoms, while researchers check…

This study is for adults with moderate to severe Crohn's disease or ulcerative colitis who have already responded to the study drug zasocitinib (TAK-279) in a previous trial. The main goal is to check the long-term safety of this oral medication over up to 3 years. Researchers wi…

This study tests whether adding freeze-dried fecal transplants (LFMT) to standard biologic therapy (vedolizumab or ustekinumab) can safely help control ulcerative colitis better than biologics alone. About 40 adults with active UC will receive either LFMT or a placebo alongside t…

This early study tests whether stimulating a nerve in the lower back can safely help control symptoms in 15 adults with moderate-to-severe ulcerative colitis that hasn't improved with standard medicines. Participants will receive the nerve stimulation and be followed for a year t…

This study aims to see if robotic surgery is a safe and effective option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to the standard laparoscopic approach, looking at things like bloo…

This study tests a small device placed under the skin near the tailbone that sends mild signals to a nerve, aiming to reduce sudden bowel urgency in people with ulcerative colitis. About 137 adults with the condition will take part. The device is implanted in a same-day procedure…

This study tests whether adding the allergy drug desloratadine to standard treatment can reduce inflammation and symptoms in people with mild to moderate ulcerative colitis. About 44 adults will take either desloratadine or a placebo alongside their usual mesalamine therapy. The …

This study tests whether adjusting sleep timing and using morning light therapy can improve symptoms and quality of life in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 68 adults with active IBD symptoms and poor quality of…

This study tests whether a special 5-day diet that mimics fasting can lower inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptom changes. The goal is to see …

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This study follows about 1,182 pregnant women with ulcerative colitis who are taking or have taken ozanimod. Researchers will watch for any health problems in the mothers and their babies, such as birth defects or pregnancy complications. The goal is to learn whether the drug is …

This study aims to understand how social factors like insurance and medication adherence affect quality of life in Hispanic and Black patients with inflammatory bowel disease (IBD). Researchers will survey 400 adults with IBD to identify barriers to effective treatment. The goal …

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study is for adults in South Korea with ulcerative colitis or Crohn's disease who are already taking vedolizumab injections. Researchers will look at medical records to track side effects and how well the treatment works. No new medicine or treatment is given—this is just an…

This study looks at whether a blood test measuring a protein called LRG can tell if the colon has healed in people with ulcerative colitis. Researchers will check the blood test results against colonoscopy findings in 100 participants. If successful, this could reduce the need fo…

This study tests whether a vitamin B3-like supplement called nicotinamide riboside is safe and practical for children with mild to moderate ulcerative colitis. About 40 kids will take the supplement and have colonoscopies to check changes in their cells over 6 to 12 months. The m…

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy, after childbirth, and while breastfeeding. The goal is to better understand and manage IBD in women of chi…

This study looks at whether ultrasound can detect scarring (fibrosis) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from 50 adults undergoing routine colonoscopy. The goal is to develop better ways to measure disease …

This study asks people with certain cancers whether they prefer getting their immunotherapy (nivolumab or pembrolizumab) as a quick shot under the skin or as a longer IV infusion. About 880 participants will try both methods and share their preference. The goal is to understand w…

This study observes how doctors use a treat-to-target strategy for people with Crohn's disease or ulcerative colitis in routine care. Researchers will review medical records of 2000 adults over 24 months to see if adjusting treatment based on disease activity improves outcomes. N…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers will look for immune cells (T cells) that are active in inflamed tissues to find what they are attacking. The goal is to discove…

This study watches how body composition (muscle and fat) changes in 48 adults with inflammatory bowel disease (Crohn's or colitis) who start a new medication. Researchers use a simple, painless test called bioelectrical impedance to measure these changes over a year. The goal is …

This study aims to identify markers in blood and tissue samples that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will compare samples from 100 participants, including healthy controls…

This study aims to test an educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and are considering treatment with immune checkpoint inhibitors. Researchers will ask about 125 patients and their doct…

This study aims to collect blood, stool, and tissue samples from 200 children with inflammatory bowel disease (like Crohn's or colitis) and children with other gut issues but no inflammation. Researchers will use advanced technology to study the genes and cells in these samples. …

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study follows 450 adults who have early signs of inflammatory bowel disease (IBD) but no symptoms yet. Researchers want to learn how and when symptoms like diarrhea, belly pain, or bleeding develop, and what genetic or immune factors play a role. Participants are monitored o…

This study looks at whether changes in sleep can warn of a flare-up in people with Crohn's disease or ulcerative colitis. Researchers will track sleep patterns and disease activity in 216 patients in remission for one year. The goal is to see if poor sleep happens before a flare,…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…