ULCERATIVE COLITIS

This study tested a web-based telemonitoring system (TECCU) for people with moderate-to-severe inflammatory bowel disease (Crohn's or ulcerative colitis) who need strong medications. 290 adults in Spain were randomly assigned to use the system or receive usual care. The goal was …

This study looked at how safe and effective upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 105 patients took the drug as prescribed by their doctor and were followed for up to 52 weeks. The main goal was to track an…

This study tested a drug called mirikizumab in 63 children aged 2 to 17 with moderate to severe ulcerative colitis, a disease causing inflammation in the colon. The goal was to see if the drug could help control the disease and improve symptoms. Participants had already tried oth…

This small study tested whether people with mild ulcerative colitis could eat broccoli sprouts regularly and whether it would reduce inflammation. Twenty-three participants ate steamed broccoli sprouts, and researchers measured sulforaphane levels in their stool and blood. The go…

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic gut condition causing inflammation and discomfort. 85 adults received four treatments through a tube and enema. The goal was to see if donor stool could reduce sym…

This study looked at whether switching from intravenous (IV) to subcutaneous (under-the-skin) injections of the drug infliximab works just as well for adults with inflammatory bowel disease (IBD) like Crohn's disease or ulcerative colitis. 38 patients in remission were switched t…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis whose disease is not controlled by standard treatments. About 100 adults took part, and researchers looked for improvements in symptoms and gut healing. The drug targets a specific ty…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis stay in remission. About 1,300 patients who improved during an earlier 12-week study received either mirikizumab or a placebo for 40 weeks. The goal was to see if the drug could maint…

This study tested an oral medication called amiselimod (MT-1303) against a placebo in 322 adults with mild to moderate ulcerative colitis. The goal was to see if the drug could reduce disease activity over 12 weeks, with an option to continue treatment for up to 36 weeks. The tri…

This study looked at the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It included 877 adults who had already taken part in earlier RPC1063 trials. The goal was to see how well the drug controls the …

This study tested whether people with ulcerative colitis can prevent symptom flare-ups by regularly testing their stool at home for signs of inflammation. Over 700 adults in remission used a smartphone-based test kit to catch inflammation early, allowing doctors to adjust treatme…

This study tested a daily pill called ABX464 in 217 adults with moderate to severe ulcerative colitis who had already completed 16 weeks of treatment. The goal was to see if the drug could keep the disease under control for up to 96 weeks. Researchers measured remission using a s…

This study tested the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still had bowel urgency despite other treatments. The main goal was to see if the drug reduces the sudden, urgent need to use the bathroom. Participants were followed for 36 weeks …

This study looked at the long-term safety of a drug called vedolizumab in 59 children with ulcerative colitis or Crohn's disease. The children had already responded to the drug in an earlier study. The main goal was to track any side effects over time. This is a disease control s…

This study looked at the long-term safety and effectiveness of the drug Entyvio (vedolizumab) in over 1,100 people with moderate to severe ulcerative colitis. Participants received the drug as part of their regular care, and researchers tracked side effects and how well the treat…

This study tested a new daily pill, ABX464, for people with moderate to severe ulcerative colitis who did not get better with other treatments. About 636 adults and teens took either 25 mg, 50 mg, or a placebo for 8 weeks. The main goal was to see if the drug could help achieve r…

This study tested an experimental drug called ABX464 in 355 adults with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could reduce symptoms like diarrhea, bleeding, and colon inflammation. Participants receiv…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This study followed 152 adults with moderate to severe ulcerative colitis for two years to see how well tofacitinib works in everyday medical practice. Researchers measured symptom improvement and whether patients could avoid surgery or stronger medications. The goal was to under…

This study tested whether rutin, a natural substance found in plants, can reduce inflammation and improve symptoms in people with ulcerative colitis. Sixty adults with the condition took rutin to see if it could calm the immune response in the gut. The goal was to lower disease a…

This study looked at the long-term safety of adalimumab, a medicine that blocks inflammation, in 59 children with ulcerative colitis who had already completed an earlier study. Researchers tracked side effects and how well the drug controlled the disease over time. The goal was t…

This study tested a new daily pill, ABX464, in 639 people with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if ABX464 could help achieve remission (symptom relief and healing of the colon) within 8 weeks compared to a p…

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like vedolizumab or infliximab can improve healing of the colon lining in people with moderate to severe ulcerative colitis. Researchers enrolled 438 adults and measured endo…

This study looked at whether regularly measuring the amount of anti-TNF medication and related antibodies in the blood can help doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. About 260 patients were split into two groups: one where …

This study checked how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. About 300 people in Japan took Rinvoq as part of their regular care and were followed for up to 60 weeks. The main goal was to…

This early-stage study tested a bile acid supplement called TUDCA in 14 adults with active ulcerative colitis. The goal was to see if it safely reduces stress in gut cells and helps control the disease. While not a cure, it may offer a new way to manage symptoms.

This study tested an experimental drug called ABBV-668 in 30 adults with moderate to severe ulcerative colitis, a condition causing inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks. The goal was to see if it improved colon healing and re…

This study looked at whether probiotics could help people with ulcerative colitis stay in remission. Researchers followed 70 Egyptian adults for one year, checking their disease activity, body mass index, and gut bacteria. The goal was to see if probiotics could help control the …

This study followed 102 people with ulcerative colitis in Sweden who were prescribed tofacitinib as part of their regular care. Researchers used national registry data to see how well the drug controlled disease activity and whether patients stuck with their treatment. The goal w…

This early-stage study tested whether MB310, a treatment made from gut bacteria, is safe for people with active mild-to-moderate ulcerative colitis. 29 adults received either MB310 or a placebo. The main goal was to check for side effects, while also looking for signs that the tr…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard adalimumab injection to a higher-concentration version. Researchers measured injection site pain and how well patients stuck with the new treatment over 180 d…

This study looked at whether eating gluten-free can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults each spent one week on a gluten-free diet and one week eating high-gluten foods, while tracking their symptoms. The goal was to see if a glu…

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This study looked at whether a short-term, low-calorie plant-based diet (called a fasting mimicking diet) could help reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD completed three 5-day diet cycles. R…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This study tested whether a prebiotic (a type of fiber that feeds good gut bacteria) can improve symptoms in people with mild to moderate ulcerative colitis. 38 adults took either the prebiotic or a placebo for four weeks, then switched. Researchers measured symptom changes, gut …

This study looked at over 107,000 people in Germany to understand the long-term side effects of steroid medications (glucocorticoids) used for conditions like asthma, arthritis, and lupus. Researchers compared those who took steroids with those who did not, tracking problems like…

This completed Phase 2 trial tested whether Aquamin, a mineral supplement, changes how leaky the gut is in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy individuals. 35 participants took Aquamin for 90 days, and researchers measured gut perme…

This study took small tissue samples from 16 people with or without inflammatory bowel disease during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how radiation and potential treatments affect these organoids…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Both are standard techniques used during screening. The goal was to learn which appr…

This study explored whether simple, low-cost blood tests can help track disease activity in people with ulcerative colitis. Researchers compared these blood markers with standard colonoscopy and stool tests in 80 patients. The goal was to see if these blood tests could be a relia…

This study watched 165 people with inflammatory bowel disease (IBD) in Poland who were already taking or starting vedolizumab. Researchers did not give any treatment—they simply recorded whether patients chose intravenous (IV) infusions at a clinic or subcutaneous (SC) shots at h…

This study tested a new scoring system called CAT-DESIRE to better measure how severe ulcerative colitis is during colonoscopy. Researchers looked at colonoscopy images from 235 adults with UC to see if the new score is reliable and can predict long-term outcomes. The goal is to …

This study looked at nearly 24,000 older adults (65+) with ulcerative colitis or Crohn's disease to compare infection rates among those taking ENTYVIO, TNF-alpha inhibitors, or ustekinumab. Using Medicare claims data from 2016-2025, researchers tracked serious infections requirin…

This study looked at how well two newer biologic drugs (ustekinumab and vedolizumab) work for Crohn's disease in 50 Chinese patients. Researchers checked for things like healing of the gut lining and symptom improvement, and also looked for side effects. The goal was to find out …

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study looked at 343 adults who had inflammatory bowel disease (Crohn's or ulcerative colitis) as children. Researchers wanted to see if their illness affected their jobs and education compared to the general population. They used surveys to collect information on work status…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This early-stage study tested whether the oral biologic MB-001 is safe in 48 healthy adults aged 18 to 65. Participants received either a single dose or five daily doses of the drug or a placebo, and were monitored for side effects. The goal was to gather safety data before testi…