ULCERATIVE COLITIS

This study tests an oral medication called tofacitinib in children aged 2 to 17 with moderate to severe ulcerative colitis, a chronic bowel disease causing inflammation and bleeding. The goal is to see if the drug can bring the disease into remission (no symptoms and healed gut l…

This study follows about 500 adults with moderate to severe ulcerative colitis who are starting filgotinib. Researchers want to see how long people stay on the drug, how well it controls symptoms, and how it affects quality of life. It is an observational study, meaning no extra …

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard dosing. The goal is to se…

This early study tests CP101, a pill made from healthy gut bacteria, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the bacteria can safely take hold in the gut and help control the disease. Participants receive either a short or extended course of C…

This study tests an experimental drug called ALTB-268 in 50 adults with moderate-to-severe ulcerative colitis that did not improve with biologic therapies. The goal is to see if the drug can reduce disease activity, measured by a symptom and scope score. Participants receive the …

This study tests a new drug called MK-7240 (tulisokibart) in about 1020 people with moderate to severe ulcerative colitis, a chronic bowel disease. Participants receive either the drug or a placebo to see if it helps achieve remission (fewer symptoms and healed gut lining) at 12 …

This study looks at whether taking a common ulcerative colitis medication (5-ASA) in the morning versus the evening can better control hidden inflammation and improve gut health. About 32 adults with inactive ulcerative colitis but signs of low-level inflammation will take their …

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for a period, and researchers will measure change…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study looks at the long-term safety of filgotinib, a drug for ulcerative colitis, in over 1,100 adults who already took part in a filgotinib trial. The main goal is to track side effects and lab test changes over time. Participants must have completed a prior filgotinib stud…

This study tests a new drug called lutikizumab for people with moderate to severe ulcerative colitis, a condition causing inflammation and bleeding in the colon. About 156 adults will receive either lutikizumab or the standard drug adalimumab to see which works better and is safe…

This study tests an experimental pill, TAK-279, against a placebo in 207 adults with moderate to severe ulcerative colitis. The goal is to see if TAK-279 can reduce bowel inflammation and symptoms like diarrhea and bleeding. Participants take the pill or placebo for 12 weeks, the…

This study tests whether a plant-based starch, tailored to each child's needs, can help restore a healthier gut microbiome in children with inflammatory bowel disease (Crohn's or colitis). About 100 children with mild disease or in remission will receive the starch for 6 months. …

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard treatment can help people with severe ulcerative colitis or hard-to-treat inflammatory bowel disease. About 44 adults will be randomly assigned to get either …

This study looks at the long-term safety and effectiveness of the drug etrasimod for people with moderate to severe ulcerative colitis. Participants had already taken part in earlier studies and will continue taking etrasimod for up to 2 years. The goal is to see if the drug can …

This study tests a new drug called rosnilimab in 132 adults with moderate to severe ulcerative colitis. The goal is to see if it can reduce disease activity and improve symptoms compared to a placebo. Participants must have tried other treatments without success. The trial is act…

This early-stage study tests whether delivering a patient's own stem cells directly into the blood supply of the colon is safe for people with moderate to severe ulcerative colitis. The trial includes 20 adults aged 18-65 who have not responded to at least two standard medication…

This study tests an experimental drug called emvistegrast (GS-1427) in about 228 adults with moderate to severe ulcerative colitis. Participants receive either the drug or a placebo, and researchers check if symptoms improve after 12 weeks. The goal is to see if the drug can redu…

This study tests whether a daily pill called ABX464 can help people with moderate-to-severe ulcerative colitis stay in remission. Over 1,100 adults who completed an earlier treatment phase will take either 25 mg, 50 mg, or a placebo for 44 weeks. The goal is to see if the drug sa…

This study tests a remote monitoring system (smartphone app and medication support) to help people with inflammatory bowel disease (IBD) take their medications as prescribed and track symptoms. About 123 adults starting a new oral or injectable IBD treatment will use the system o…

This study tests an oral medication called upadacitinib in children aged 2 to 17 with moderate-to-severe ulcerative colitis who have not improved with standard treatments. The goal is to see if the drug can reduce inflammation and control symptoms like diarrhea and bleeding. Part…

This study tests whether a fecal transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 children aged 3-21 and track whether the infection comes back.…

This study tests a drug called guselkumab in people with moderate to severe ulcerative colitis, a chronic bowel disease. Over 1,000 participants received either the drug or a placebo to see if it reduces symptoms like diarrhea and bleeding. The goal is to control the disease and …

This study looks at how well and how safely the drug mirikizumab works over the long term (up to 3 years) for people with moderate to severe ulcerative colitis. About 1,058 adults who were already in earlier studies will continue taking the drug. The goal is to see if it can keep…

This study looks at whether a gluten-free diet can help people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Researchers will track changes in symptoms, lab results, and gut bacteria in 60 adults over time. The goal is to see if avoiding gluten c…

This study tests two approved drugs, risankizumab and vedolizumab, to see which works better for adults with moderate to severe ulcerative colitis who haven't tried targeted treatments before. About 530 participants will receive one of the two medications and be monitored for saf…

This study tests whether transplanting healthy donor stool into the gut can safely control ulcerative colitis over the long term. About 30 patients aged 10 to 80 with mild to moderate disease will receive the treatment and be followed for 48 weeks. The goal is to reduce symptoms …

This study tests whether transplanting healthy stool bacteria can help people with ulcerative colitis, a chronic gut disease. About 150 adults with active symptoms will receive either a fecal transplant or a sham procedure. The goal is to see if this approach can reduce inflammat…

This study was designed to see if MitoQ, an antioxidant supplement, can help control inflammation in children aged 6–17 with mild-to-moderate ulcerative colitis. Participants would have taken MitoQ or a placebo daily for 24 weeks alongside their usual treatment. The goal was to r…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study looks at the long-term safety and effectiveness of a daily pill called ABX464 for people with moderate to severe ulcerative colitis. About 200 participants who were already in earlier studies will take the drug for up to 54 months. The goal is to see if the drug can ke…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce the risk of colon cancer in people with long-standing ulcerative colitis who carry a specific genetic mutation (P53). About 42 participants will take either atorvastatin or a placebo for a per…

This study tests whether Aquamin, a natural mineral supplement from red algae, can improve symptoms and help maintain remission in people with mild ulcerative colitis. About 40 adults with confirmed ulcerative colitis who are either in stable remission or have mild disease will t…

This study looks back at medical records of about 1,000 adults with Crohn's disease or ulcerative colitis in Brazil who are taking or have taken vedolizumab. The goal is to see how long people stay on the drug and what other treatments they used before. No new treatments or tests…

This study is watching 500,000 adults with chronic gut conditions like Crohn's disease, ulcerative colitis, and eosinophilic GI disease. Researchers are collecting health records and patient reports to learn how these diseases progress and how well treatments work. No new treatme…

This study follows 15,000 adults and children (age 2+) with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) for up to 5 years. Researchers will collect information on how the disease progresses, how well treatments work, and any side effects tha…

This study looks at whether taking the probiotic VSL#3 can change how the body processes bile acids in people with Crohn's disease or ulcerative colitis. About 79 adults with stable, inactive disease will take the probiotic for 6 weeks. Researchers will measure bile acid levels i…

This study tests a program to help teens aged 16-17.5 with Crohn's disease or ulcerative colitis transition from pediatric to adult healthcare. The program includes personalized assessments, a navigator, and online skill-building sessions. Researchers will measure how well partic…

This study follows 535 adults with moderate-to-severe ulcerative colitis who are taking or will take Simponi. The goal is to track long-term safety, including serious side effects like infections, cancers, and pregnancy outcomes. Researchers will also check how well the disease i…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study looks at how the drug infliximab behaves in people hospitalized with severe ulcerative colitis. Researchers measure drug levels in blood, stool, and colon tissue to understand how it works. About 18 adults will take part, and the goal is to learn more about the drug's …

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This study examines prescription patterns in 4000 adults with ulcerative colitis to understand how treatments are used and to create an updated treatment roadmap. Researchers will track which patients achieve early control of inflammation and compare outcomes for those who stay o…

This study follows nearly 5,000 children with Crohn's disease, ulcerative colitis, or indeterminate colitis to monitor the long-term safety of their treatments, including the drug infliximab. Researchers collect information on side effects, disease activity, and quality of life o…