ULCERATIVE COLITIS

This study tests a new diet designed to meet the higher protein needs of people with ulcerative colitis while also reducing harmful gas produced by gut bacteria. Researchers will measure changes in stool samples from 40 adults with mild to moderate disease. The goal is to see if …

This study looks at whether adding acupuncture to standard medication (mesalazine) can help people with mild-to-moderate ulcerative colitis reach and stay in remission. About 80 adults will receive either the combined treatment or medication alone. The goal is to see if the combi…

This study will test if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can help people with many different conditions, including long COVID, Crohn's disease, frostbite, and more. About 100 people will take part. The goal is to see if the treatment impr…

This study tests a new drug called ATH-063 in people with moderate-to-severe ulcerative colitis who have not responded to biologic treatments. About 120 adults will receive either the drug or a placebo to see if it can reduce symptoms like diarrhea and bleeding. The goal is to fi…

This study tests a steroid foam (budesonide) given rectally to children aged 5 to 17 with mild to moderate distal ulcerative colitis. The goal is to see if it can safely induce remission by reducing inflammation, bleeding, and stool frequency. About 100 children will receive eith…

This study observes 35 adults with moderate-to-severe Crohn's disease or ulcerative colitis to see how long they continue taking guselkumab in everyday medical practice. Researchers will track treatment persistence and early symptom relief, like reduced bowel urgency. No experime…

This study tests a blood-filtering device called Efferon LPS in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone …

This study tests whether a natural mineral supplement called Aquamin can prevent pouchitis—a painful inflammation of the J-pouch—in people who had surgery for ulcerative colitis. About 52 participants who recently had J-pouch surgery will take Aquamin or a placebo. The goal is to…

This study tests whether a 5-week heart rate variability biofeedback program can reduce symptoms like belly pain and urgency in 23 adults with ulcerative colitis who are currently having a flare but show no active gut inflammation. Participants will learn breathing techniques to …

This study will test a one-day acceptance and commitment therapy (ACT) program designed for veterans who have both inflammatory bowel disease (IBD) and mental health conditions like depression, anxiety, or PTSD. The goal is to help them improve their daily functioning and quality…

This study tests a self-management program designed to help people with inflammatory bowel disease (IBD) improve their health and quality of life. Researchers will enroll 40 adults with active IBD to see if the program is practical and acceptable. The goal is to understand if cha…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other inflammatory bowel diseases (IBD), plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, and tissue samples, along with imaging and diet information, to understa…

This study looks at whether measuring belly fat with CT scans can help predict how well biologic therapy works in people with ulcerative colitis. Researchers will track changes in fat volume over 6 months in 200 adults. The goal is to find a better way to match patients with effe…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

This study looks at whether a simple intestinal ultrasound can accurately measure disease activity in people with active ulcerative colitis, compared to the standard colonoscopy. Researchers will enroll 200 adults with active UC to see if the ultrasound scores match the colonosco…

This study follows 50 adults with ulcerative colitis who are already seeing a naturopathic doctor. Over 12 weeks, researchers track symptom changes using questionnaires. The goal is to gather early information on how naturopathic care may help, without changing anyone's usual tre…

This study aims to understand why children with ulcerative colitis (UC) are more likely to get C. difficile infections. Researchers will compare bile acid profiles and gut bacteria in 80 children: those with active UC and C. diff, those with active UC alone, those in remission, a…