MYELODYSPLASTIC SYNDROME

This study is testing a stem cell transplant from a partially matched family donor for patients with hard-to-treat blood cancers like leukemia and lymphoma. Before the transplant, patients receive chemotherapy and radiation to wipe out their own bone marrow and cancer cells. The …

This study is testing a new drug called elritercept against a standard drug (epoetin alfa) for adults with a bone marrow disorder (MDS) who have anemia and need regular blood transfusions. The main goal is to see if elritercept can help patients go longer periods without needing …

This early-stage trial is testing a new drug called SEA-CD70, both alone and combined with other cancer medications, for people with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The main goal is to find safe doses and understand the side effects in adults whos…

This study is testing a new oral drug, seclidemstat, combined with an existing drug, azacitidine, for adults with certain advanced blood cancers (MDS and CMML) that have not responded well to prior treatment. The main goals are to find the safest and most effective dose of the ne…

This study is testing a combination of three drugs—quizartinib, decitabine, and venetoclax—to treat acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). It is for older adults who are not candidates for standard intensive chemotherapy or for those whose disea…

This study is testing a combination of four chemotherapy drugs (cladribine, idarubicin, cytarabine, and venetoclax) to see how well they work against aggressive forms of blood cancer, including acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (MDS), and chronic my…

This early-stage study is testing a new drug called RPT1G in patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have returned or not responded to standard treatments. The main goals are to find out if the drug is safe, what side effects i…

This early-stage study is testing a new type of stem cell transplant for adults aged 60-75 with acute leukemias or myelodysplastic syndrome (MDS). The approach combines a precise form of radiation targeting bone marrow and lymph nodes with chemotherapy, followed by an infusion of…

This study is testing a refined procedure for umbilical cord blood transplants in adults and children with high-risk blood cancers like leukemia and lymphoma. The goal is to see if this optimized approach improves survival and reduces complications compared to standard transplant…

This study is testing if adding a new drug, enasidenib, to a standard treatment works better for controlling a high-risk type of myelodysplastic syndrome (MDS), a bone marrow disorder. It will involve about 54 adults with a specific genetic change (IDH2 mutation) who have not had…

This study is testing whether a medication called canakinumab, given as a monthly injection, can help control certain low-risk blood and bone marrow disorders. It aims to see if the treatment improves blood counts, reduces the need for blood transfusions, and is safe for patients…

This early-stage study aims to find a safe and effective dose of a new targeted drug, pivekimab sunirine, when given with a standard chemotherapy regimen (FLAG-Ida). It is for adults newly diagnosed with aggressive, high-risk blood cancers like acute myeloid leukemia (AML). The n…

This study is testing if adding a drug called venetoclax to a standard chemotherapy and stem cell transplant regimen works better for adults with high-risk forms of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see if this combination helps contro…

This early-stage study is testing the safety and initial effectiveness of adding a new drug, FHD-286, to a standard two-drug treatment for acute myeloid leukemia (AML). It is for adults with newly diagnosed high-risk AML or AML that has come back after one prior treatment. The ma…

This study aims to find better treatments for children and young adults whose leukemia has returned or is hard to treat. It screens patients' blood and bone marrow to understand their specific cancer and match them to new, targeted therapy trials. The goal is to control the disea…

This early-stage study is testing whether adding metal-detoxifying drugs to standard chemotherapy can help control acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Researchers want to see if lowering metal levels in the blood and bone marrow improves treatment res…

This study is testing a new combination of three oral drugs (ASTX727, venetoclax, and gilteritinib) for adults with specific types of acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that have a genetic change called an FLT3 mutation. The first part aims t…

This study is testing whether giving standard cancer treatments at home is as safe and effective as giving them in a clinic. It aims to see if receiving care at home reduces stress, improves quality of life, and is preferred by patients with advanced cancers. About 220 participan…

This study is testing a combination of two drugs, azacitidine and quizartinib, for adults with advanced forms of blood and bone marrow cancers (like myelodysplastic syndromes). The goal is to find the safest and most effective dose and see if the combination can help control thes…

This study tests whether adding the drug ruxolitinib to two standard medications helps prevent graft-versus-host disease (GVHD) in children and young adults receiving bone marrow transplants for blood cancers. GVHD is a serious complication where donor immune cells attack the pat…

This study tests whether combining two medicines—enasidenib and azacitidine—can help control acute myeloid leukemia that has returned or hasn't responded to previous treatments. It's for patients whose cancer has a specific genetic change called an IDH2 mutation. Researchers want…

This early-stage study is testing the safety of a new drug, SL-401, when combined with standard medications for certain aggressive blood cancers. It aims to find the highest safe dose for patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or blastic plasm…

This study is testing a combination of four drugs to see if they can improve blood counts in adults with aplastic anemia or low-risk myelodysplastic syndrome (MDS). The treatment aims to calm an overactive immune system that may be attacking the bone marrow, while also boosting w…

This study is testing a new combination of targeted drugs for people with advanced blood cancers that have a specific genetic change called an IDH1 mutation. The main goals are to find the safest dose and see how well the drug combo works to control the cancer. The trial is for a…

This study is testing a modified, two-step stem cell transplant procedure designed to be safer. It aims to reduce deaths caused by the transplant treatment itself in patients with various blood cancers and disorders. The trial compares two gentler preparation methods using lower …

This early-stage trial is testing a new treatment for patients whose blood cancers have returned or not responded to standard therapies. The treatment uses a modified virus that is designed to selectively infect and kill cancer cells while sparing healthy ones. Researchers are st…

This early-stage study is testing the safety and initial effectiveness of a new drug, rezatapopt, combined with an existing drug, azacitidine, for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The trial is specifically for patients whose cancer has a…

This early-stage trial is testing a new combination of three drugs for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or not responded to other treatments. The goal is to find the safest and most effective dose by combining an immunot…

This study is testing a medical device called MEX-CD1 that works like dialysis to filter excess iron from the blood. It is for patients with myelodysplastic syndrome or myelofibrosis who need regular blood transfusions, which cause dangerous iron buildup, but who cannot tolerate …

This early-stage trial is testing a new drug called BMS-986497 for adults with acute myeloid leukemia or myelodysplastic syndrome that has returned or resisted previous treatments. Researchers will give the drug alone and in combination with two standard cancer medications to fin…

This study is testing the safety of a new type of stem cell transplant for children whose cancers have come back or are very hard to treat. Doctors use a half-matched family donor and a special process to remove certain immune cells from the transplant, aiming to reduce complicat…

This study is testing whether changing the timing of a standard immune-suppressing drug (ATG) can better prevent severe graft-versus-host disease (GVHD) after a stem cell transplant. The trial will enroll 56 adults with acute leukemia, myelodysplastic syndrome, or myeloproliferat…

This early-stage study is testing whether a two-drug combination is safe and can help prevent cancer from coming back in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after they receive a stem cell transplant from a donor. The treatment involves tag…

This is a first-in-human study to find a safe dose of a new drug called cirtuvivint for patients with advanced forms of blood cancer. The trial will test cirtuvivint by itself in patients whose cancer has returned or resisted treatment, and also test it combined with an existing …

This study tests a personalized immune cell therapy for patients with blood cancers like leukemia, lymphoma, and myeloma. After receiving chemotherapy and a cord blood transplant, patients get infusions of natural killer (NK) cells—immune cells that may kill remaining cancer cell…

This study is testing whether combining two drugs, CPX-351 (a chemotherapy) and ivosidenib (a targeted pill), can help control a specific type of acute myeloid leukemia or high-risk MDS that has an IDH1 gene mutation. It will involve about 30 adults who are eligible for intensive…

This study is for people with acute leukemia or myelodysplastic syndrome (MDS) who need a stem cell transplant from a donor. The main goal is to find the best way to reduce a serious complication called graft-versus-host disease (GVHD), where the donor's immune cells attack the p…

This trial is testing whether a combination of chemotherapy and targeted drugs can better prepare patients with advanced blood cancers for a stem cell transplant. The goal is to control the aggressive cancer enough so patients can safely receive donor stem cells, which may offer …

This early-stage trial is testing whether a drug called olutasidenib can safely prevent certain blood cancers from returning after a patient has received a donor bone marrow transplant. The study will enroll about 15 adults with acute myeloid leukemia, myelodysplastic syndrome, o…

This study is testing whether adding a targeted drug called venetoclax to a standard chemotherapy regimen works better than the current standard treatment for newly diagnosed acute myeloid leukemia (AML). It will involve about 102 adults and aims to see if the new combination lea…

This trial is testing a new drug called SP-420 to see if it can safely remove excess iron from the liver in adults with certain blood disorders. People with transfusion-dependent beta-thalassemia or low-risk myelodysplastic syndrome often need regular blood transfusions, which ca…

This study is testing a new, faster treatment plan for adults aged 60 and older with aggressive blood cancers like acute myeloid leukemia (AML). The goal is to see if giving strong chemotherapy followed quickly by a lower-intensity stem cell transplant is safer and more effective…

This early-stage trial is testing a new cell therapy for children and adults whose leukemia has come back or persists after a donor stem cell transplant. Doctors take immune cells (T cells) from the original donor, genetically modify them to better recognize and attack the patien…

This early-stage trial is testing a new vaccine designed to prevent serious cytomegalovirus (CMV) infections. The study involves patients with blood cancers who are receiving a stem cell transplant from a partially matched donor, a procedure that carries a high risk of CMV. Resea…

This study is testing a new vaccine approach to prevent a common and serious viral infection called CMV in patients receiving a stem cell transplant for blood cancers. Researchers are giving the vaccine to the healthy stem cell donors, hoping the donor's boosted immunity will be …

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether a curcumin supplement, the active ingredient in turmeric, can reduce inflammation and improve symptoms in people with certain blood cell disorders. Researchers will compare the supplement to a placebo in 30 participants over 12 months. The main goals…

This study aims to understand if a targeted radiation therapy for neuroendocrine tumors (PRRT) increases the risk of patients later developing serious blood cancers like myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Researchers will collect and analyze blood sam…

This study is a large screening program designed to help match adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) to the most appropriate treatment study within the national MyeloMATCH network. It involves testing a patient's bone marrow and blood for spec…

This study collects tissue and fluid samples from adults and children with cancer. The goal is to gather these samples for research to help scientists better understand cancer and develop new tests and models for future treatments. Samples are collected during procedures patients…

This study is collecting information about how patients with blood cancers and disorders respond to stem cell transplants in the high-altitude Tibetan region. Researchers are enrolling 1000 patients and their donors to track treatment patterns, recovery times, survival rates, and…

This study is developing more sensitive blood tests to find tiny amounts of hidden cancer cells that remain after treatment for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Researchers want to see if these tests can identify patients who are at higher risk of t…

This study aims to gather detailed information on many different blood diseases in China, including cancers like leukemia and lymphoma, and conditions like hemophilia. It will follow 2,300 patients to learn how common these diseases are, what treatments patients receive, how well…