MYELODYSPLASTIC SYNDROME
Clinical trials for MYELODYSPLASTIC SYNDROME explained in plain language.
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New drug combo tested for Tough-to-Treat blood cancers
Disease control CompletedThis early-stage study tested a combination of two drugs, bortezomib and lenalidomide, in 22 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) had returned after a stem cell transplant. The main goal was to find the highest dose of this drug pair that co…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Apr 01, 2026 18:41 UTC
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New drug combo tested for Tough-to-Treat blood disorder
Disease control CompletedThis small, early-stage study aimed to find a safe dose for combining two existing drugs, ibrutinib and lenalidomide, to treat myelodysplastic syndrome (MDS). It involved patients whose MDS had not responded to or who could not tolerate standard treatments. The main goal was to c…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: University of California, Davis • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New drug combo aims to fight back when leukemia returns after transplant
Disease control CompletedThis study tested a two-part treatment for people whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a donor stem cell transplant. It combined a drug called guadecitabine, which may slow cancer growth, with infusions of the donor's white blood ce…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Donor immune cells bolster transplant against blood cancer relapse
Disease control CompletedThis study tested whether adding 'off-the-shelf' natural killer (NK) immune cells from a donor could make stem cell transplants more effective for adults with high-risk forms of leukemia. The goal was to see if this combination was safe and could help prevent the cancer from comi…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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New drug combo tested to fight Leukemia's return after transplant
Disease control CompletedThis early-stage study tested two immunotherapy drugs, nivolumab and ipilimumab, in patients with high-risk or returning acute myeloid leukemia or myelodysplastic syndrome who had already received a donor stem cell transplant. The main goals were to find safe doses and check for …
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Early trial tests Four-Drug combo to train immune system against blood cancers
Disease control CompletedThis early-stage study tested a combination of a cancer vaccine, chemotherapy, and immunotherapy in 8 patients with certain high-risk blood cancers. The main goal was to check the safety of this four-drug approach and see if it could help the body's immune system better target an…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 23, 2026 15:29 UTC
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New combo drug trial aims to tame aggressive blood cancers
Disease control CompletedThis large, completed study tested if adding a new drug called pevonedistat to the standard treatment (azacitidine) could better control certain aggressive blood cancers. It involved 454 adults with high-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or low-blas…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE3 • Sponsor: Takeda • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Gentler transplant strategy tested for tough blood cancers
Disease control CompletedThis study tested a two-step, lower-intensity stem cell transplant for patients with high-risk blood cancers like leukemia and lymphoma. The goal was to use milder chemotherapy and radiation before the transplant to reduce side effects while still allowing the donor's immune cell…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University • Aim: Disease control
Last updated Mar 02, 2026 15:26 UTC
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Scientists search for secret to bouncing back after cancer treatment
Knowledge-focused CompletedThis study aimed to identify what helps older adults recover well after a bone marrow transplant for blood cancers like leukemia and lymphoma. Researchers measured physical ability, mental health, stress hormones, and other factors in 126 patients aged 60 and older before and aft…
Matched conditions: MYELODYSPLASTIC SYNDROME
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Knowledge-focused
Last updated Mar 18, 2026 14:41 UTC