MYELODYSPLASTIC SYNDROME
Clinical trials for MYELODYSPLASTIC SYNDROME explained in plain language.
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New hope for older leukemia patients: targeted radiation before transplant may reduce side effects
Disease control Not yet recruitingThis study tests a new way to prepare older patients (50 and older) with leukemia or MDS that has not responded to treatment for a stem cell transplant. Instead of full-body radiation, they receive targeted radiation to the bone marrow and lymph nodes, plus two chemotherapy drugs…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 17, 2026 00:30 UTC
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New combo therapy targets hard-to-treat blood cancers in phase 2 trial
Disease control Not yet recruitingThis study tests whether adding the drug olutasidenib to standard treatments helps people with certain blood cancers (AML or MDS) that have an IDH1 gene mutation. About 132 adults will receive either standard therapy alone or with olutasidenib. The goal is to see if the combinati…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 00:29 UTC
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Engineered immune cells take aim at Hard-to-Treat blood cancers
Disease control Not yet recruitingThis early-phase study tests a new treatment called CD64 CAR T cells for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, mod…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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New combo therapy aims to boost red blood cells in bone marrow disorder
Disease control Not yet recruitingThis study tests whether adding epoetin alfa or emavusertib to luspatercept improves red blood cell counts better than luspatercept alone in 270 adults with low-risk myelodysplastic syndrome and anemia. Participants will receive one of three treatment combinations. The goal is to…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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Exercise-Powered immune cells take on leukemia in first human trial
Disease control Not yet recruitingThis early-stage study tests whether donor immune cells collected after exercise can better prevent or treat leukemia relapse in patients who had a stem cell transplant. About 94 participants with various blood cancers will receive these special cells either to prevent relapse or…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: University of Arizona • Aim: Disease control
Last updated May 13, 2026 16:03 UTC
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New hope for young blood cancer patients: QUAIL-100 trial launches
Disease control Not yet recruitingThis early-stage study tests a new drug, QUAIL-100, in 12 children and young adults with high-risk leukemia or myelodysplastic syndrome who have already received a special type of stem cell transplant. The main goal is to check the drug's safety and side effects. Participants wil…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: Laguna Biotherapeutics, Inc. • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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Scientists eye protein on Pre-Leukemia cells as potential CAR-T target
Knowledge-focused Not yet recruitingThis study looks at a protein called IL-1RAP found on abnormal cells in myelodysplastic syndromes (MDS), a pre-leukemic condition. Researchers will collect blood and bone marrow samples from 120 high-risk MDS patients to confirm IL-1RAP expression and test whether specially desig…
Matched conditions: MYELODYSPLASTIC SYNDROME
Phase: NA • Sponsor: University Hospital, Grenoble • Aim: Knowledge-focused
Last updated May 13, 2026 16:02 UTC
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Scientists study immune cells to unlock better leukemia monitoring
Knowledge-focused Not yet recruitingThis study collects blood and bone marrow samples from 55 adults with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndrome. Researchers will analyze natural killer (NK) cells and their interactions with cancer cells over time. The goal is to learn whi…
Matched conditions: MYELODYSPLASTIC SYNDROME
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Apr 23, 2026 12:45 UTC