New drug combo offers hope for tough blood cancers

NCT ID NCT06419634

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug, BMS-986497, in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or not improved after prior treatments. The drug is given alone or combined with standard medicines (azacitidine and venetoclax). The main goals are to check safety, find the best dose, and see if the drug helps control the cancer. About 105 adults will take part.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA MYELODYSPLASTIC SYNDROME

Contacts and locations

Locations

Columbia University Irving Medical Center
WITHDRAWN

New York, New York, 10032, United States
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Catalunya [Cataluña], 08036, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Local Institution - 0007
WITHDRAWN

Boston, Massachusetts, 02114, United States
Local Institution - 0009
WITHDRAWN

Fairfax, Virginia, 22031, United States
Local Institution - 0017
NOT_YET_RECRUITING

Marseille, Bouches-du-Rhône, 13273, France
Local Institution - 0018
NOT_YET_RECRUITING

Paris, 75010, France
Local Institution - 0022
NOT_YET_RECRUITING

Toulouse, 31100, France
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Washington University School of Medicine, Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63108, United States
Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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