DIABETES

This study looked at whether treating gum disease (periodontitis) can help improve blood sugar control in adults with diabetes. 91 participants were randomly assigned to receive either gum treatment right away or after the study ended. The main measure was a change in hemoglobin …

This study tested a healthy eating and exercise program to help people with early Type 2 diabetes achieve remission. 35 overweight adults in low-income Memphis neighborhoods participated. The program focused on a plant-forward diet and coaching support, aiming for weight loss and…

This completed study tested whether a special type of health education, focused on patient empowerment, helps adults with type 2 diabetes better manage their condition. Fifty participants were randomly assigned to receive either the empowerment-based education or standard care. T…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study tested whether coaching through a hospital's online patient portal helps adults maintain weight loss after losing at least 5% of their body weight. 269 participants either tracked their weight, diet, and activity on their own or also received coaching from regular clin…

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used the system at home to see if it improves time in target blood sugar range compared to standard care. The …

This study tested if a new device, used through a scope, could safely help regenerate the lining of the small intestine in people with type 2 diabetes. Twenty adults whose diabetes was not well controlled with 2-3 non-insulin medications took part. The main goal was to check safe…

This study looked at whether adding the antibiotic rifampin to usual treatment can prevent amputations in diabetic patients with serious foot bone infections. Over 800 veterans took part. The goal was to see if the combination works better than standard care alone to save limbs.

This study tested a new way to deliver HIV and chronic disease care by bringing services into community microfinance groups in rural Kenya. About 1,200 adults with HIV took part, with some receiving care in the community and others at usual clinics. The goal was to see if combini…

This study tested whether a natural plant compound called phytosterol can help people with non-alcoholic fatty liver disease (NAFLD). Twenty-seven adults took the supplement for three months to see if it improved liver enzymes, cholesterol, insulin levels, and inflammation. The g…

This study tested a new insulin called 22011 against a standard insulin (Ryzodeg) in 414 Chinese adults with type 2 diabetes. The goal was to see if the new insulin works just as well and is as safe. Results showed similar blood sugar control over 26 weeks, offering a potential a…

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study looked at whether a class of diabetes drugs called GLP-1 receptor agonists can improve heart function and reduce fat around the heart in obese people with type 2 diabetes. The researchers measured heart fat and function using MRI scans in 44 participants. The goal was …

This study tested a program called Family Check-Up Heart, which adds heart-health coaching to regular home visits for new moms and their babies. About 150 mothers who had Medicaid and recently gave birth took part. The goal was to see if the program could help moms manage weight,…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This study looked at whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes or pre-diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. The goal was…

This pilot study tested whether a closed-loop system (artificial pancreas) could automatically control blood sugar in 5 adults with type 1 diabetes who already use an insulin pump and continuous glucose monitor. The system used special algorithms to decide how much insulin to giv…

This study tested whether a lifestyle program combining nutrition counseling, exercise advice, and possibly medication could help people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty adults from a family medicine clinic took…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This early-stage study tested a new drug called CT-388 in 129 overweight or obese adults, some with type 2 diabetes. The goal was to see if the drug is safe and how it affects body weight and blood sugar. Participants received either the drug or a placebo as a shot under the skin…

This study tested a personalized lifestyle program for 232 overweight or obese Hispanic pregnant women to help them gain a healthy amount of weight during pregnancy and lose it after birth. The program included diet and exercise guidance tailored to their culture and language. Th…

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. 61 participants were assigned to either the program or standard care. The goal was to see if these lif…

This study tested an AI-based system called X-Life that gives personalized lifestyle advice to adults with type 2 diabetes. 124 participants used the system along with glucose monitors and activity trackers to see if it helped them keep their blood sugar in a healthy range more o…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate four different diets over 20 weeks, with blood pressure measured regularly.…

This study tested a virtual culinary medicine program for 89 adults with type 2 diabetes and high body mass index. Participants took online cooking classes to learn healthy eating habits. Researchers measured changes in blood sugar (HbA1c), weight, and cholesterol to see if the p…

This study tested if the pill glyburide works as well as insulin shots for treating gestational diabetes (diabetes during pregnancy). Over 900 pregnant women took part. The main goal was to see if babies had fewer problems like being very large, having low blood sugar, or jaundic…

This study tested a program where community health workers helped young adults (ages 18-35) from underrepresented minority groups with type 1 diabetes start using devices like continuous glucose monitors and insulin pumps. Over 9 months, 119 participants were randomly assigned to…

This study tested a program to help South Asian adults with uncontrolled diabetes lower their blood sugar (HbA1c). The program included health coaching, referrals to community resources, and better coordination between patients and their healthcare team. Over 850 people took part…

This study looked at whether community health workers (CHWs) can improve health outcomes for people with chronic conditions like diabetes, high blood pressure, and obesity. Over 10 months, 202 low-income adults from specific zip codes received either CHW support plus standard car…

This study looked at whether getting blood sugar under control for a short time before major abdominal surgery can lower the chance of problems or death. It included 53 adults with uncontrolled diabetes (HbA1c of 7.5% or higher) who were scheduled for surgery lasting over 2 hours…

This study tested a new device that measures blood sugar without needing a finger prick. It compared the device's readings to standard blood tests in 40 adults, including healthy people, those with prediabetes, and those with type 2 diabetes. The goal was to see if the non-invasi…

This study explored whether a new technique called surface-enhanced Raman spectroscopy (SERS) can diagnose diabetes using a simple blood sample. Researchers used gold nanoparticles and a laser to create unique light patterns from the blood of 52 people, including healthy voluntee…

This study tested a new automated screening tool called OPTDR01 for diabetic retinopathy, a leading cause of vision loss. The goal was to see if it could be easily used in primary care settings to help more people get screened, especially those with limited access to eye speciali…

This study tested a program that gives healthy food incentives and coaching to adults at risk for diabetes. The goal was to help them stick with healthy habits and lower their chances of getting diabetes. 61 participants joined the program, and researchers tracked weight, blood s…

This study tested a program that sends text reminders and uses social support and game-like challenges to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults from a University of Pennsylvania kidney cl…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study looked at whether foot-ankle exercises or walking exercises can help people with type 2 diabetes who have nerve problems in their feet. 375 adults with diabetes were split into three groups: one did foot-ankle exercises, one did walking exercises, and one received only…

This study tested a new method called inforatio to help heal diabetic foot ulcers. The technique involves making small cuts in the wound to trigger the body's natural healing response. 100 adults with diabetes and foot ulcers that had not healed for at least 6 weeks took part. Th…

This study tested a personalized home exercise program for 34 cancer survivors who also had diabetes or high blood pressure. Participants chose from four exercise options (like walking or yoga) and used a wearable device to track their heart rate. The goal was to see if the progr…

This study tested whether a 12-week foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life better than walking or standard care. 108 participants were split into three groups: foot-ankle exercises, walking, or education o…

This study tested a mobile health program designed to support family caregivers who look after someone with both dementia and diabetes. Sixty caregivers used a smartphone-based supportive care program for three months. The goal was to reduce caregiver burden and improve social su…

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol levels after meals—key risk factors for type 2 diabetes and heart disease. Researchers compared normal-weight and overweight/obese South Asian adults, a g…

This study looked at whether a continuous glucose monitor (Freestyle Libre) can help track blood sugar levels in diabetic patients who are starting chemotherapy. 103 adults with diabetes and cancer took part. The goal was to see how often their blood sugar went too low or too hig…

This study tested a new AI system called X Life that gives personalized health advice to people with type 2 diabetes or prediabetes. The system uses data from continuous glucose monitors, activity trackers, and sleep sensors. Twenty participants used the system to see if it was e…

This study looked at whether viral infections and diabetes in pregnant women increase the risk of congenital heart defects in babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future la…

This study looked at medical records from over 740,000 older adults with diabetes to see if the drug semaglutide (used for diabetes) might lower the risk of developing dementia or Alzheimer's disease. Researchers compared people taking semaglutide to those taking other diabetes d…

This study tested a 12-week program where people with overweight or obesity, who were already taking weight loss medication, used a Fitbit and worked with a health coach. The goal was to see if this approach could help them become more active and improve their health. The study e…

This study looked at how often low blood sugar (hypoglycemia) happens in elderly people with diabetes who live in nursing homes. Low blood sugar can be very dangerous for older adults, causing falls, confusion, and even death. The researchers used a continuous glucose monitor to …

This study looked at 120 people having hand or wrist surgery to see if those with kidney failure or diabetes recover feeling from a nerve block more slowly than those without these conditions. Researchers measured how long numbness lasted after the block. The goal was to learn ho…

This early-phase study tested whether a substance called apelin can improve how the body uses insulin in people with type 2 diabetes. Nine overweight adults with diabetes received apelin while researchers measured their body's response to sugar. The goal was to gather initial saf…

This study looked at whether teaching mothers about their family health history could help them encourage healthier eating and exercise in their families. About 310 adults took part, completing surveys and using a special tool to learn about their risk for diabetes, cancer, and h…

This study looked at how family members talk about genetic health risks like sickle cell, diabetes, cancer, and heart disease. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand how sharing this information …

This study looked at how many calories people burn through physical activity and whether that affects weight gain and diabetes risk. Researchers followed 2500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US for two years. They measured activity levels with …

This study compared risk factors for diabetes and heart disease in healthy African, African-American, and white women aged 25-65 who work for the federal government. Researchers measured things like blood sugar, insulin, and body fat to see if different screening tests work bette…

This study looked at a recently discovered hormone called 26RFa, which may be linked to appetite and blood sugar control. Researchers measured its levels in 62 obese women (some with type 2 diabetes) before and after weight-loss surgery, and compared them to healthy-weight volunt…

This study looked at how two diabetes drugs, metformin and HRS-7535, behave in the bodies of 18 healthy men. Participants took the drugs in a fixed order, and researchers measured drug levels and side effects. The goal was to gather information, not to treat any disease.

This study tested whether sending diabetes education and resource links by text message to emergency department patients with diabetes could improve their knowledge, reduce diabetes-related distress, and encourage self-care. Fifty adults with poorly controlled or new-onset diabet…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study checked whether acetaminophen (Tylenol) interferes with a new continuous glucose monitor called Biolinq. 31 adults with diabetes wore the sensor for three days and took the painkiller on the last day. Researchers compared sensor readings to lab blood tests to see if th…

This study looked at how vitamin E is absorbed and used in the bodies of 50 women, including those who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after meals with different amounts of fat and vitamin E. The g…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors change kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drug's effect on estimated glomerular filtration rate (eGFR) dif…

This study looked at how lifestyle changes like diet and exercise affect blood sugar in 61 adults with diabetes. Researchers used advanced tests (genomics, proteomics, metabolomics, and microbiomics) to find the key molecules and pathways involved. The goal was to build a model t…

This study tested whether a program that combines job training with employer support can lower the risk of chronic diseases like diabetes and heart disease in unemployed, low-income adults. Researchers measured changes in stress, weight, and blood pressure over 12 months. The goa…

This study tested whether continuous glucose monitors (CGMs) can help track blood sugar levels in hospitalized adults with diabetes. Forty patients wore a CGM device during their hospital stay to see how well it detects dangerously low or high blood sugar events. The goal was to …

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study looked at whether replacing sitting time with standing or walking can help control blood sugar in South Asian adults who are overweight or obese. 18 participants changed their daily routines to sit less and move more. The results showed that these simple swaps led to b…

This study looked at 142 people who had sinus lift surgery to add bone for dental implants. Researchers measured how much bone was left in the upper jaw before surgery and tracked bone loss around the implants for up to 12 years. They also considered smoking, diabetes, and implan…

This study looked at whether online referrals from doctors to a food program called WIC (for Women, Infants, and Children) would increase enrollment. 240 pregnant women receiving care at Geisinger were split into four groups: some got usual care, some got a digital referral, some…

This study looked at how Mexican-American families discuss their risk for diseases like diabetes, heart disease, and certain cancers. Researchers interviewed 498 adults from the same households to understand how culture and family ties help or hinder these conversations. The goal…

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it related to death, heart events, and recovery. They also tested if a di…

This study tested whether combining health information technology with practice facilitation (coaching for clinics) could increase how often doctors refer diabetes patients to diabetes self-management education and support (DSMES). The study involved 22 clinics and measured refer…

This study looked at over 30,000 adults hospitalized in a statewide medical system to understand why some patients wait in the emergency department after being admitted (called boarding) and how this affects costs and care. Researchers analyzed existing medical records to find pa…

This study measured how different diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems. 234 adults who had lost weight were followed. Participants drank special water to track their energy use and provided urine samples over…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study looked at how eating a high-fat diet for just 5 days changes the way muscles use sugar and fat. Researchers studied 11 healthy men to see if this short-term diet causes muscle problems similar to those seen in people with diabetes. The goal was to learn more about what…

This study tested a new workbook that uses word games to teach people with diabetes how to manage their condition. 25 participants completed the workbook during clinic visits or at home, and then attended follow-up sessions. The goal was to see if the workbook was easy to use and…

This study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers examined patients' genes, medical histories, and family members to identify new forms of diabetes. The goal was to better understand these genetic subtypes, not to test a…

This study followed 514 people with stable coronary artery disease for 18 months to see if how their bodies handle triglycerides (a type of fat) after a meal could predict future heart problems. Researchers also looked at blood sugar control and other health markers. The goal was…