DIABETES

This study provides continuous glucose monitors (CGMs) at no cost to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easier access to real-time blood sugar data helps lower A1c levels and improves quality of life. Participants wear the sensor for 14-d…

This study looks at whether a program that combines clinic support and digital health coaching can help low-income patients with diabetes or high blood pressure better manage their conditions. About 600 adults will take part, and researchers will track changes in blood sugar leve…

This study tests a device that uses automated ultrasound to check how well a dialysis fistula (a surgically created blood vessel connection) is maturing in people with end-stage kidney disease and diabetes. About 304 participants will be randomly assigned to get biweekly automate…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take either sodium bicarbonate or a placebo …

This study tests a mobile health app that gives older adults with diabetes personalized, real-time tips to help them manage their condition. The goal is to see if the app can improve blood sugar control and self-care habits. The study will involve 184 participants and last for 6 …

This study looks at how fat cells work in normal-weight people with type 2 diabetes compared to those who are overweight or don't have diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adu…

This study looks at whether adding occupational therapy or dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with a dietitian, meals with occupat…

This pilot study tests whether providing free produce boxes to Veterans with kidney disease and food insecurity can improve their health. Researchers will measure blood pressure and kidney function, and interview participants about their experience. The study aims to see if this …

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study tests a program called Inspire HER, designed to improve heart health in Black women aged 30-79 who have heart, kidney, or metabolic risks. Participants will receive health education, physical activity guidance, and social support. The goal is to see if the program is p…

This study tests whether a program led by community health workers can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will either receive peer support and help finding community resources, or just basic health info…

This early-stage trial tests transplanting insulin-making cells into the front chamber of the eye to treat diabetes. Only 2 participants with severe vision loss in one eye will receive the transplant, along with immunosuppressive eye drops to prevent rejection. The goal is to see…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health. Participants use a home blood pressure monitor and get support from community health workers and pharmacists via phone or video. The goal is to see if this extr…

This study looks at how well the Omnipod 5 automated insulin delivery system works in real life for people with type 1 diabetes. About 304 participants, aged 2 and older, will use the system for the first time. Researchers will measure blood sugar control, quality of life, and sa…

This study provides 400 adults with diabetes or prediabetes who face food insecurity with free fresh food boxes and nutrition education twice a month for six months. Researchers will measure changes in blood sugar levels and food security to see if this program helps control diab…

This study looks at whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) plus lifestyle changes is better than lifestyle changes alone for treating obesity and a serious liver condition called MASH. About 132 adults with a BMI of 30 or higher …

This study tests whether a once-weekly injection of dulaglutide (a GLP-1 agonist) can improve early insulin release and blood sugar control in 30 adults with cystic fibrosis who have pancreatic insufficiency and abnormal glucose tolerance. Participants will receive the drug or no…

This study tests a program to help people with low income who have chronic health problems like diabetes, heart disease, or lung disease take their medicines correctly after leaving the hospital. The program provides free medicines, delivers them to the bedside and then home, and…

This study tests whether a daily tablet of semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside their usual care. The goal is to see if t…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump for 13 weeks or continue their regular treatment. The goal is to see if the pump improves blo…

This study tests whether using a continuous glucose monitor (CGM) helps people with type 2 diabetes who have limited access to healthcare better control their blood sugar. Researchers will compare blood sugar levels and other health outcomes between two groups over six months. Th…

This study tests a diabetes program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities. About 140 adults with type 2 diabetes who care for a young person aged 10-25 will take part. The program focuses on…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study looks at whether weight-loss surgery can help people with type 2 diabetes achieve long-term remission better than the best medical care. About 408 obese adults with diabetes will be followed to see how surgery affects blood sugar, kidney function, and heart health. The…

This study compares three different programs to help pregnant women and new mothers maintain a healthy weight. About 795 participants will receive either usual care, a self-management program, or a community-based program. The goal is to see which approach best reduces weight gai…

This study tests a new insulin drug, GZR4, against another insulin (Insulin Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar and medications. About 376 adults with uncontrolled diabetes will be placed into one of four groups: usual care, pharmacist …

This study tests whether an AI tool can help doctors find undiagnosed heart failure in people with type 2 diabetes. About 800 participants will have their heart ultrasound results analyzed by the AI, and doctors will get alerts suggesting preventive medications. The goal is to st…

This study aims to find the most effective way to screen for diabetes in people who take steroids (glucocorticoids) for more than three months. Steroids can raise blood sugar and cause diabetes, but current screening methods vary. Researchers will compare three tests—fasting bloo…

This study compares a self-administered oral glucose tolerance test (OGTT) at home using a continuous glucose monitor (CGM) with the standard clinic-based OGTT. 75 adults with prediabetes will undergo both tests to see if the home version accurately diagnoses blood sugar problems…

This study tests an AI software called iPredict-DR that analyzes eye photos to find early signs of diabetic retinopathy, a leading cause of blindness. About 922 adults with diabetes will get their eyes checked with a special camera in primary care clinics. The goal is to see if t…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Thirty participants aged 12-19 will wear the device for 72 hours and provide breath samples. The goal is to see if breath chemicals can replace finger-prick tests f…

This study is testing a new glucose sensor called the ROME GS System to see if it is safe and accurate for people with type 1 or type 2 diabetes. About 60 adults will wear the sensor for up to 90 days. Researchers will compare its readings to standard lab tests and track any side…

This study tests a new device that uses a special light (Raman spectroscopy) to measure blood sugar without needing a finger prick. It will include 49 people with diabetes and healthy volunteers to see how accurate the light-based method is compared to the standard finger-stick t…

This study tests two lifestyle programs in 400 older African American and white adults at risk for memory loss and diabetes. One group does aerobic exercise classes; the other gets dietary coaching to follow the MIND diet (rich in berries, greens, and fish). The goal is to see if…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether taking an antibiotic pill for 7 days after surgery for a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no extra anti…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. About 70 parents with prediabetes and their children (ages 8-15) will join a 20-month program to improve diet, activity, and weight. The goal is to see if parent…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This early-phase study tests whether a weight-loss drug called tirzepatide can safely help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. About 30 participants will take the drug and be monitored for side effects.…

This study tests a new bandage called exciflex that delivers small electrical pulses to help heal chronic wounds in the legs. It is for Veterans with diabetes or spinal cord injury whose wounds are not healing normally. The bandage can stay on for up to seven days and aims to imp…

This study is testing a special type of talk therapy delivered by video call to help young adults with type 1 diabetes who also have anxiety or depression. The therapy includes reviewing blood sugar data from a continuous glucose monitor. The goal is to see if this approach reduc…

This study looks at whether a program called enCompass Humana can help family caregivers of people with cancer and diabetes feel more supported and less stressed. The program offers coaching and help finding resources. About 162 caregivers will take part to see if the program is …

This study collects genetic and health information from 3,000 people to help doctors choose the safest and most effective medications. Participants include those taking multiple medications or specific drugs for blood pressure or depression. The goal is to reduce side effects and…

This study tests a tele-education program for primary care providers at federally qualified health centers across the U.S. Over six months, providers receive twice-monthly virtual training sessions from experts at the University of Florida. The goal is to see if this training hel…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…

This study looks at whether stem cells from taste buds can be turned into cells that produce insulin, which could lead to new diabetes treatments. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells. The goal is to…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study aims to find biological markers that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples from 5,000 adults with diabetes and an open foot ulcer. The goal is to improve personalized treatment decisions and make future wound-heali…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will compare vitamin C in blood and urine from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goal is to …

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study looks at whether whole or nonfat milk is better for body composition and heart health in children aged 9 to 12 who have a higher BMI. Researchers will measure fat mass, lean mass, and other health markers over one year. The goal is to understand which type of milk supp…

This study aims to make sure that lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone/muscle conditions are accurate and give the same results each time. About 100 healthy volunteers and people with these conditions will provide sam…

This study is looking for a way to predict which older adults with diabetes might become confused after surgery. Researchers will measure specific proteins in the blood before surgery and see if they are linked to confusion in the days after. The goal is to better understand and …

This study looks at how your genes and your environment work together to influence health conditions like diabetes, heart disease, and asthma. Researchers will collect health information and DNA from 25,000 adults to build a unique resource for future research. Participants must …

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. Researchers want to see tiny structures, like cells and blood flow, that regular eye exams miss. About 1,200 adults with various eye conditions or healthy volunteers will be image…

This study follows about 4,000 adults from Shanghai communities to see how their heart, kidney, and metabolic health changes over time. Researchers will track new cases of diseases like diabetes, high blood pressure, and heart problems. The goal is to better understand how these …

This study tests a digital tool called CGM ASSIST for people with both Alzheimer's disease (or other dementias) and diabetes. The tool uses a continuous glucose monitor and easy-to-read displays to help patients, caregivers, and doctors spot and prevent dangerously low blood suga…

This study will check how often people with cystic fibrosis-related diabetes (CFRD) develop eye, kidney, and nerve problems. Researchers will also look at blood pressure and cholesterol. About 200 teens and adults with CFRD for at least 5 years will take part. The goal is to bett…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the need for radiation or invasive tests. Researchers will compare these new MRI methods with standard tests like angiography in up to 4,000 adults, including healthy volunteers and…

This study looks at whether connecting people with diabetes to community services can help meet their social needs, like food, housing, and transportation. It will involve about 12,000 adults in rural Kentucky. The goal is to see if this approach improves health and well-being.

This study uses a special PET-MR scan to measure the activity of an enzyme called histone deacetylase in the heart. Researchers will compare enzyme levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how this enzyme r…

This study looks at how a substance called lactate affects blood flow in the brain. People with obesity often have trouble processing lactate, which may impact brain health. Researchers will compare brain blood flow in 24 adults with and without obesity, and test if short-term ex…

This study looks at whether a special computer program can help doctors better manage blood sugar levels in hospitalized adults. The tool alerts doctors when a patient's blood sugar is too high or too low, so they can act quickly. Researchers will track how long patients stay in …

This study will follow 2000 adults with metabolic syndrome or prediabetes for many years. Researchers will track health changes, nutrition, and physical function to understand how these conditions progress and lead to complications. The goal is to find key factors that affect lon…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure pancreatic fat in 100 adults aged 18–80. The goal is to better understand how this fat…

This study is creating a biobank—a collection of DNA samples and health information—from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to provide a foundation for future medical discoveries, not to test …

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. About 120 adult…

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a device at home to check their baby's heart rate. Fifty participants will try the remote monitor for 30 minutes, three times a week, starting at 32 weeks. The goal i…

This study will enroll about 2,920 adults with type 2 diabetes to create an early warning system for diabetic retinopathy, an eye complication that can lead to blindness. Researchers will combine eye images, routine health tests, and metabolism markers to better predict who is at…

This study follows about 2,800 unpaid caregivers (family or friends) who care for someone with a chronic condition like diabetes or Batten disease. Researchers want to understand how the stress of caregiving affects caregivers' health, well-being, and social life over up to 5 yea…

This study looks at people with type 2 diabetes who have nerve damage in their legs. Researchers will use ultrasound to measure the size and appearance of leg nerves and then test how well participants walk and keep their balance. The goal is to see if nerve ultrasound findings c…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study tests whether a training session for hospital doctors can improve how they manage blood pressure and diabetes medications for older adults (65+). Doctors attend one educational session and complete surveys before and after. Researchers also call patients to see if they…

This study aims to learn how cerebral small vessel disease (CSVD) develops and worsens over time. Researchers will follow 50 adults who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Participants will get three MRI scans over 15 m…

This study collects blood, tissue, and other biological samples from 10,000 volunteers, including healthy people and those with conditions like cancer, heart disease, and diabetes. The samples are stored in a biobank and shared with researchers to uncover how diseases develop and…

This study asks adults with type 1 diabetes who use a closed-loop insulin pump how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Up to 900 participants will fill out a questionnaire about their experiences. The g…

This study looks at 450 people aged 60 and older with diabetes who are having major non-heart surgery. It compares two common anesthetics, sevoflurane and propofol, to see which one lowers the chance of confusion (delirium) after surgery. Participants will be randomly assigned to…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study uses MRI scans to measure pancreas size in pregnant women and their unborn babies. Researchers want to see how the pancreas changes during pregnancy and how those changes are linked to diabetes. The goal is to better understand diabetes risk for both mother and child. …

This study aims to improve how we measure metabolism by looking at body size and composition in 2,000 people aged 2 and older. Participants include healthy volunteers and those with conditions like diabetes, obesity, or cancer. Over a 2-day hospital stay, they will undergo variou…

This study aims to build trust and partnerships with communities of color in Colorado to increase participation in health research. Researchers will work with local organizations to address health issues like mental health, high blood pressure, and diabetes. The study involves 1,…

This study looks at whether obesity raises heart disease risk differently in African American men and women compared to other groups. Researchers will measure body fat, blood fats, and insulin function in 2,000 healthy African American adults. The goal is to understand why heart …

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The goal is to better understand how dia…

This study looks at whether screening for social needs (like housing or food) with a focus on antiracism can help reduce chronic diseases such as high blood pressure, diabetes, and asthma. About 68,000 adults and children in primary care will take part. The goal is to see if this…