DIABETES

This study looks at whether a tighter blood sugar target (70-140 mg/dL) is better than the current standard (70-180 mg/dL) for children and teens with Type 1 Diabetes who use automated insulin delivery systems. About 120 participants from three countries will be randomly assigned…

This study looks at whether adding a supplement called HMB to an exercise program can help older adults (ages 60-80) with type 2 diabetes and low muscle mass gain muscle, get stronger, and improve insulin resistance. About 120 participants will be randomly assigned to exercise, H…

This study tests a combination of four drugs (epalrestat, HAIC chemotherapy, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the c…

This study tests Mobili®, a portable digital dispenser that gives the right pills at the right time and alerts pharmacists if doses are missed. About 96 adults with diabetes or heart disease who take at least two daily medications will use the device. The goal is to see if it imp…

This study tests whether group care—where patients meet together for education, support, and check-ups—can help control high blood pressure and diabetes better than standard one-on-one visits. About 1,110 adults in Nepal will take part. The goal is to see if this approach improve…

This study tests a 6-week program where older adults (55+) with both diabetes and mild memory problems work with their caregivers to improve diabetes self-care and thinking skills. About 309 participants will attend weekly sessions and give feedback. The goal is to see if this te…

This study tests whether a special AI tool can help community doctors improve care for people with high blood pressure plus diabetes or high cholesterol. About 6,800 adults will be split into two groups: one gets usual care, the other gets AI-assisted management. The goal is to s…

This study tests whether empagliflozin, a diabetes drug, can help people who have had islet cell transplants and still have partial pancreas function. About 40 adults will take either a low dose, a higher dose, or no drug for 3 months to see if it improves their blood sugar contr…

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This study looks at whether a GLP-1 RA drug (a type of diabetes medication) can improve fat levels in the liver and blood of people with metabolic fatty liver disease (MASLD), type 2 diabetes, and obesity. Researchers will measure changes in fats, proteins, and genes in liver tis…

This pilot study will test whether a continuous glucose monitor (CGM) can safely guide automated insulin infusions in non-ICU hospital patients with diabetes who are also receiving steroids and specialized nutrition. About 80 cancer and post-transplant patients will be randomly a…

This study looks at whether sending reminders by text, email, or patient portal messages helps people with heart disease or diabetes refill their statin prescriptions. About 22,000 adults will receive different types of reminders, and researchers will track who refills their medi…

This study tests whether an enhanced diabetes prevention program that provides healthy food deliveries, exercise classes, and community resources helps African American adults with prediabetes lose more weight than a standard program. About 408 participants from low-income commun…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study looks at whether pregnant people with type 1 or type 2 diabetes can safely keep using their insulin pump during labor instead of switching to IV insulin. About 30 participants will use their own pump under a hospital safety plan, and their results will be compared to p…

This study tests if a mild electrical pulse to the ear can help control nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis (slow stomach emptying). Researchers will use a small device on the outer ear to stimulate the vagus nerve, hoping it improve…

This study looks at whether the drug sodium phenylbutyrate (NaPB) can change blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. Researchers will measure how well blood vessels work and check amino acid levels in the blood.

This study tests a 12-week home-based exercise program combining aerobic and resistance training for older adults (60+) with type 2 diabetes and early signs of muscle weakness (probable sarcopenia). The goal is to see if short, manageable workouts can increase daily physical acti…

This study is testing a new AI-powered tool called AIManage to help doctors and patients better manage medications for diabetes, obesity, and side effects. The tool will assist with adjusting doses of incretin mimetic drugs (like Ozempic or Wegovy). In the first phase, researcher…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study will use a non-invasive ultrasound device (transcranial Doppler) to measure blood flow in the brains of 100 adults who have had a stroke and received endovascular treatment. The goal is to see if these measurements can help predict complications like brain swelling or …

This study is testing a new wrist-worn device that uses light and AI to estimate blood sugar levels without needles. About 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. Par…

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This study tests a mobile app that wirelessly sends blood sugar readings from continuous glucose monitors (CGMs) used by children with diabetes in the hospital to a central database. The goal is to see if the app can accurately and reliably share this data so doctors and nurses c…

This study looks at how eating meals with different amounts of fat, carbs, and protein changes fat levels in the blood. Researchers will study 100 adults, including healthy volunteers and people with conditions like diabetes, metabolic syndrome, or kidney disease. Participants wi…

This study will see if community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. About 300 adults who are medically underserved will work with a CHW to create a personal hea…

This registry follows 500 people with type 2 diabetes who have already been treated with the Endogenex System. The goal is to monitor long-term safety by tracking any device- or procedure-related side effects. No new treatment or intervention is given; participants simply provide…

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study collects blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and liver disease. The samples are used to develop and fine-tune new diagnostic tests that can be performed right at the pati…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic problems. Researchers will collect medical information, questionnaires, and blood, saliva, urine, and stool samples during routine clinic visits. The goal is to learn how thes…

This study looks at how to make it easier for doctors to screen patients for physical inactivity and refer them to community exercise programs. Researchers will work with 35 clinics and their patients to see if this approach helps people become more active and improve health cond…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study will collect health information from 10,000 adults with diabetes, metabolic disorders, or related conditions like high blood pressure and fatty liver disease. Researchers will track things like blood sugar, weight, and lab results over at least 10 years to find better …

This study looks at whether giving primary care providers a report card on how well they follow treatment guidelines can improve care for patients with high blood pressure and diabetes. Researchers will compare providers who get this feedback to those who don't, across four count…