DIABETES

This study tests whether a natural substance called maslinic acid, found in olives, can safely activate brown fat—a type of fat that burns calories—to improve metabolism in people with obesity or early signs of diabetes. Fifty Chinese adults aged 21–60 with a BMI of 23–32 and a l…

This study tests a new insulin (GZR4) that is injected just once a week, compared to a standard daily insulin (degludec), in 620 adults with type 2 diabetes who already use basal insulin. The goal is to see if the weekly shot controls blood sugar just as well or better, with fewe…

This study tests a program where community paramedics visit adults with diabetes who have had severe low blood sugar (hypoglycemia). The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. About 150 participants from s…

This study compares a new diabetes-specific nutritional formula to an existing one in 103 adults with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. The goal is to see if the new formula is as good as the current one at improving nutrition, mea…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes abnormal fat storage and leads to diabetes and high blood fats. Participants, aged 6 months and older, have already received the drug through NIH studies but cannot get it…

This study tests whether a combination of a GLP-1 receptor agonist and long-acting insulin works better than standard insulin therapy for people with steroid-induced diabetes. About 100 adults with conditions like asthma or arthritis who take steroids will participate. The goal i…

This study aimed to see if placing a stent in a blocked leg vein could help heal diabetic foot ulcers faster. It planned to compare standard wound care plus a stent versus standard care alone. However, the trial was withdrawn before enrolling any participants, so no results are a…

This study looks at whether adding the medication insulin detemir to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight. It also checks how the drug affects brain areas linked to food pleasure and mood. About 240 adults aged 31-60 will be split into…

This study looks at whether giving low-income people with diabetes or high blood pressure a monthly grocery card ($80 or $120) can help them better manage their health. About 4,450 adults in California will receive the benefit for a year. Researchers will track changes in food se…

This study is testing whether giving people free boxes of fruits and vegetables, along with nutrition tips, can help manage health problems like diabetes, high blood pressure, and obesity. About 300 adults in the Mississippi Delta who are overweight or have high blood sugar will …

This study looks at whether taking a yerba mate extract (a plant from South America) for 90 days can improve health markers like weight, blood sugar, and cholesterol in 80 overweight adults aged 40-65. Participants will be randomly assigned to receive either the extract or a plac…

This study tests whether a church-based program led by community health workers can improve heart health in Black communities more effectively than group education alone. About 812 adults aged 40 and older with heart disease risk factors will take part. The goal is to reduce raci…

This study looks at how well the Joslin Why WAIT? program helps people with type 2 diabetes and obesity lose weight and improve their health. About 110 participants who have a BMI over 35 are included. The main goal is to see if they can lose at least 7% of their body weight and …

This study offers the drug metreleptin to 29 people with partial lipodystrophy, a rare condition causing high blood fats and diabetes. Participants, aged 6 months and older, have already benefited from metreleptin in earlier NIH studies and cannot get it elsewhere. The goal is to…

This study looks at whether pharmacists can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity will receive pharmacist-led support. The goal is to see if this approach lowers overall cardiovascular risk…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can help manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers (like breast, prostate, or lung) and at …

This study tests if giving people with obesity and diabetes a $160 monthly subsidy to buy fruits and vegetables online helps them eat healthier. 214 participants will be split into groups to see which approach works best. The goal is to improve diet and possibly blood sugar contr…

This study looks at whether eating more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose more weight than a lower-protein diet (15% of calories). Over 10 weeks, kids follow a calorie-restricted diet and increase physical activity at a camp,…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet helps them control blood pressure, blood sugar, and weight better than standard care. About 49 adults who had a kidney transplant in the past 2–12 months and have high blood pressu…

This study tests a new insulin called GZR4 that is given once a week, compared to the standard daily insulin, in 580 adults with type 2 diabetes who already use insulin. The goal is to see if the weekly shot controls blood sugar just as well or better, with fewer injections. Part…

This study tests a new once-weekly insulin (GZR4) against a standard daily insulin in adults with type 2 diabetes who have never used insulin before. About 580 participants will receive either the weekly shot plus other diabetes pills or the daily shot plus other pills. The goal …

This study evaluates a home collection kit that lets people with diabetes mail in a small blood sample to check their HbA1c levels, a key marker of blood sugar control. The goal is to see if the kit is accurate and easy to use, potentially reducing the need for clinic visits. Abo…

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get the eye exams they need. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take part. The goal …

This study tests whether giving extra support—like phone calls and added resources—to Black adults who don't lose weight early in a diabetes prevention program can help them succeed. About 400 participants from churches and community centers will take part. The goal is to prevent…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, nutrition advice, mental health support, and parent groups to help families feel calmer and more in control. About 100 children and their families will take part to see if this approac…

This study looks at whether a mindfulness-based stress reduction program and yoga can lower stress, improve quality of life, and help control blood sugar in teenagers with type 1 diabetes. About 90 teens aged 13 to 18 will take part. The goal is to see if these mind-body practice…

This study tests a culturally tailored support program for 300 Chinese and Korean American caregivers (age 50+) of relatives with dementia. The program combines counseling with online peer support groups to reduce stress, depression, and health risks like diabetes and heart disea…

This study looks at how COVID-19 may change organs like the heart, lungs, or kidneys in people who have diabetes compared to those who don't. Researchers will follow 35 adults who had COVID-19 and were discharged from the hospital 2 to 6 months earlier. The goal is to better unde…

This study looks at differences in body composition, fitness, and temperature control during exercise between young soccer players with type 1 diabetes and healthy ones. Forty boys who have trained for at least 5 years will be monitored with thermal cameras and continuous glucose…

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study tests whether a Learning Health System (LHS) can help primary care teams in Thailand better manage high blood pressure, diabetes, and kidney disease. About 419 patients from 16 clinics will take part, with clinics randomly assigned to use the LHS or continue usual care…

This study looks back at medical records of over 46,000 diabetic patients who had surgery in Alberta, Canada. Researchers want to see how often patients had a recent HbA1C test (a measure of long-term blood sugar control) before their operation. They also want to find out if poor…

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic and other markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve e…

This study brings together five universities and community groups to help Black and Latino adults in the Washington, D.C., Maryland, and Virginia area who have diabetes, prediabetes, high blood pressure, or obesity. Community health workers will connect participants to health and…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study compares eight different recruitment methods to see which one best gets adults with diabetes to schedule and attend a pharmacist appointment for medication help. Participants are adults with poorly controlled diabetes who struggle to take their medicines as prescribed.…

This study looks at whether treating patients at home for conditions like infections, heart failure, and diabetes can lead to better health outcomes and satisfaction compared to a hospital stay. About 9,600 adults will receive hospital-level care in their own homes through a digi…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, eggs, dairy) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study was designed to see if diabetic patients have slower stomach emptying after fasting, which could raise the risk of vomiting during surgery. Researchers planned to use ultrasound to compare stomach contents between diabetic and non-diabetic patients before scheduled vas…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD). Researchers will collect blood samples from 25 adults with type 1 diabetes to measure changes in specific molecules called microRNAs. The goal is to better understand this for…

This study aims to understand how bariatric surgery affects the body's tissues, like fat, muscle, and liver, and how it improves insulin sensitivity. Researchers will collect tissue and blood samples from 500 adults undergoing surgery or other procedures. The goal is to learn the…

This study looks at how diabetes impacts the quality of life, lung function, and nutrition of adults with cystic fibrosis. Researchers will compare those with and without diabetes using questionnaires and breathing tests. The goal is to better understand these effects to improve …

This study tests whether wearable devices like Fitbits and continuous glucose monitors can reliably track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people find them…

This study looks at how a single dose of the experimental drug GZR4 injection behaves in people with mild, moderate, or severe liver impairment compared to those with normal liver function. The goal is to understand the drug's safety and how the body processes it. 36 adults with …

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This study looks at whether a fast, on-the-spot blood test for diabetes markers (HbA1c and cystatin C) can help doctors manage diabetes better and protect kidney health. About 222 adults with diabetes from a hospital in Taiwan will be followed. The goal is to see if quick results…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

This study looks at how certain immune proteins, called the complement system, might make kidney disease worse in people with diabetes. Researchers will measure these proteins in blood and urine from 90 participants. The goal is to understand the role of the immune system in kidn…