Uveal disorder

This early-phase trial tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) before eye removal surgery is safe and feasible for people with high-risk uveal melanoma, a rare eye cancer. Fifteen participants will receive the drugs, then have their eye removed. Th…

This study tests a new treatment called LB-DTK-CMV for people with cytomegalovirus (CMV) retinitis that has not responded to standard antiviral medicines. The treatment uses a patient's own immune cells, specially trained to attack CMV, and is given as two infusions. The trial ai…

This phase 3 trial tests whether the drug tebentafusp can prevent uveal melanoma from coming back in high-risk patients after their initial treatment. About 290 people with a specific genetic marker (HLA-A*02:01) will either receive weekly infusions of tebentafusp or be observed …

This study tests a personalized treatment for advanced melanoma using a patient's own immune cells, called tumor-infiltrating lymphocytes (TIL), which are boosted with a protein called CD40L. After a short course of chemotherapy to make room, the enhanced cells are infused back a…

This early-phase trial tests a new drug called BI-1206, given alongside the immunotherapy pembrolizumab, in adults with advanced solid tumors that have stopped responding to prior anti-PD-1/PD-L1 treatment. The study aims to find the safest dose and check for early signs of tumor…

This study compares two devices used during cataract surgery to treat open-angle glaucoma. About 194 adults with mild to moderate glaucoma and cataracts will receive either the ELIOS device or a competitor device. The main goal is to see which one lowers eye pressure more effecti…

This study tests NOV05, a water-free tacrolimus eye drop, in 20 adults with active non-infectious anterior uveitis. Participants receive either a high or low dose for 6 weeks. The goal is to see if it safely controls inflammation and reduces the need for steroid eye drops.

This early-phase study tests a new drug (IOV-3001) designed to boost immune cells in people with advanced melanoma that has not responded to prior treatments. About 42 adults will receive the drug alongside a personalized cell therapy called lifileucel. The main goals are to chec…

This study tests a drug called tebentafusp combined with treatments directed at the liver (like embolization or chemo-embolization) for people with a rare eye cancer (uveal melanoma) that has spread to the liver. About 109 adults with a specific immune type (HLA-A*0201) will part…

This early-stage trial is testing an experimental drug called MBS8(1V270), given alone or with the immunotherapy pembrolizumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. About 1…

This study tests a drug called tebentafusp in 19 people with a rare eye cancer (uveal melanoma) that is too large to remove without taking the whole eye. The goal is to see if the drug can shrink the tumor by at least 20% so that less invasive surgery might be possible. Participa…

This study tests a new drug called IDE196 in people with certain cancers that have specific genetic mutations (GNAQ/11 or PRKC fusions). The cancers include metastatic uveal melanoma, cutaneous melanoma, and colorectal cancer. The trial has two phases: first to find safe doses, t…

This early-stage trial tests an oral drug called DF-003 in 12 people with ROSAH syndrome, a rare genetic condition causing eye inflammation, enlarged spleen, and headaches. The main goal is to check safety and how the body processes the drug, while also watching for improvements …

This study tests a new treatment made from donor immune cells (CAR-NK cells) that are designed to attack two targets on melanoma cells. It is for adults with advanced melanoma that has spread or cannot be removed and has not responded to standard therapies. The goal is to find a …

This early-phase trial tests the safety of CRD3874-SI, a drug that activates the STING pathway to boost the immune system against cancer. About 81 adults with advanced solid tumors (sarcoma, Merkel cell carcinoma, and others) will receive weekly IV infusions at increasing doses. …

This early-stage trial tests a personalized cell therapy called lifileucel for people with advanced uveal melanoma (a rare eye cancer) or certain sarcomas (connective tissue cancers). The treatment involves removing immune cells from the patient's tumor, growing them in a lab, an…

This study looks at whether starting strong immune-suppressing drugs early can help control Vogt-Koyanagi-Harada (VKH) disease, a rare condition that causes eye inflammation and vision loss. Researchers will treat 40 newly diagnosed patients with high-dose steroids and other immu…

This phase 3 trial tests darovasertib, a daily pill, given before standard local therapy (radiation or surgery) for people with uveal melanoma that hasn't spread. The goal is to see if the drug can prevent vision loss and avoid eye removal. About 520 participants will be randomly…

This study compares two FDA-approved laser treatments for open-angle glaucoma: the standard SLT and a newer, non-contact version called DSLT. Both aim to lower eye pressure and prevent vision loss. About 172 adults with glaucoma or high eye pressure will be randomly assigned to o…

This study tests an oral medication called FXS5626 in 40 adults with active non-infectious uveitis, a condition causing inflammation inside the eye. The goal is to see if the drug can control the disease better than a placebo, reducing the need for other treatments. Participants …

This study compares two small implants (XEN-63 and PRESERFLO) placed during a quick surgery to lower eye pressure in adults with open-angle glaucoma. About 166 participants will be randomly assigned to one implant and followed for 2 years. The goal is to see if PRESERFLO works as…

This early-stage trial tests whether adding a new drug called roginolisib to the existing treatment tebentafusp can help people with advanced uveal melanoma, a rare eye cancer. The study involves 8 adults whose cancer has spread and who are already on tebentafusp. The main goal i…

This study tests whether a new drug called RP2, given with nivolumab, works better than the current standard combination (ipilimumab plus nivolumab) for people with metastatic uveal melanoma, a rare eye cancer that has spread. About 280 adults who have not had prior immunotherapy…

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) done at the same time as cataract surgery. About 243 adults with mild to moderate open-angle glaucoma will take part. The goal is to see which surgery lowers ey…

This study tests a two-step treatment for people with a rare eye cancer (uveal melanoma) that has spread only to the liver. First, a chemotherapy drug is delivered directly to the liver through a special procedure. Then, an immunotherapy drug is given to help the immune system at…

This study is testing a special laser called ELIOS to treat glaucoma at the same time as cataract surgery. The laser creates tiny channels in the eye to help fluid drain and lower eye pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal i…

This study tests whether a tiny drainage device called the Preserflo MicroShunt can lower eye pressure as well as the standard trabeculectomy surgery in adults with open-angle glaucoma. One hundred participants will be randomly assigned to receive one of the two procedures and wi…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…

This early-stage trial tests a radioactive drug called [225Ac]Ac-A9-3408 in 50 adults with melanoma that has spread or can't be removed by surgery. The main goals are to find a safe dose and check for side effects. Participants receive the drug every 6 weeks for up to 6 doses, an…

This study tests whether a weak electrical current applied to the eye's surface can improve vision in people with open-angle glaucoma. Fifty adults with worsening vision loss will receive either real or sham stimulation over several sessions. The goal is to see if this safe, non-…

This phase 2 trial is testing a drug called tebentafusp in 19 people with a rare eye cancer (uveal melanoma) that has spread to the liver. Participants receive weekly infusions for 6 months, then may have surgery to remove any remaining tumors. The goal is to see if the drug can …

This Phase 3 trial tests a new drug called belzupacap sarotalocan (AU-011) for people with small choroidal melanoma or suspicious spots in the eye. The drug is injected into the eye and activated by a laser to target cancer cells. The study compares it to a sham (fake) procedure …

This study tests a drug called tebentafusp in people with a specific type of advanced eye cancer (uveal melanoma) that has spread to other parts of the body. The drug is designed to help the immune system attack cancer cells. Researchers will also use a blood test to measure tumo…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests whether combining a targeted immunotherapy (tebentafusp) with a liver-directed radiation treatment (Y-90 radioembolization) can help control metastatic uveal melanoma that has spread to the liver. About 30 adults whose cancer is mainly in the liver and who have a…

This study tests a device called the Tran cannula, used during cataract surgery to clean away debris from the eye's drainage system in patients with pseudoexfoliative glaucoma. The goal is to see if it lowers eye pressure better than standard irrigation. Fifty-eight adults with b…

This study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in patients with additional eye structure issues like lens dislocation or inflammation. About 320 adults will receive these lenses during cataract surgery, with doct…

This early-stage trial tests a new drug called ONM-501, which is injected directly into tumors, either alone or with the immunotherapy cemiplimab (Libtayo). The study includes 168 adults with advanced solid tumors or lymphomas that have not responded to standard treatments. The m…

This study tests a new oral drug called LNS8801, alone or combined with the immunotherapy pembrolizumab (Keytruda), in up to 200 adults with advanced solid tumors that have spread. The goal is to find a safe dose and see if the drug shrinks tumors. It is an early-stage trial, so …

This trial tests a tiny device called the VisiPlate shunt to help drain fluid and lower eye pressure in people with open-angle glaucoma that hasn't responded to other treatments. About 165 adults will receive the implant and be followed to see if their eye pressure drops by at le…

This study tests a device called the Calibreye System, a small implant placed in the eye to help drain fluid and lower pressure in people with open-angle glaucoma. Researchers will check if it is safe and works well over 12 months in 60 adults. The goal is to see if the device ca…

This study tests whether two drugs, cemiplimab and ziv-aflibercept, can shrink or stop the growth of metastatic uveal melanoma, a rare eye cancer that has spread. About 32 adults with this condition will receive the combination treatment. The goal is to see if the drugs work bett…

This study tests an experimental drug called NBM-BMX in people with metastatic uveal melanoma, a rare eye cancer that has spread to other parts of the body. The goal is to find the best dose, check for side effects, and see if the drug can shrink or slow tumors. Participants take…

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety in a small group of 10 patients. It is not a cure, but …

This study tests if two devices placed in the eye can safely lower eye pressure in people with moderate to severe open-angle glaucoma. Participants have not responded well to drops or laser and are considering surgery. The goal is to see if these implants can be a less invasive a…

This early-stage trial tests a new drug called NN3201 in people with advanced cancers that have a specific marker called c-Kit. The drug is designed to deliver a chemotherapy agent directly to cancer cells, potentially killing them while sparing healthy tissue. The study will enr…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study tests a new diagnostic method called metagenomic sequencing to find hidden infections in people with eye inflammation (uveitis). Standard tests often miss the cause. Researchers will analyze fluid from the eye to detect bacteria, viruses, fungi, or parasites. The goal …

This phase 2 trial tests whether the drug quisinostat can prevent uveal melanoma from spreading in high-risk patients. About 63 people who have completed initial treatment for their eye tumor will take quisinostat capsules three times a week. Researchers will track how long parti…

This phase 3 trial tests whether two different eye treatments can prevent vision loss in people who have had radiation therapy for a type of eye cancer called uveal melanoma. The study will compare faricimab injections given every 3 months, a fluocinolone acetonide implant placed…

This study looks at whether a laser treatment called DSLT can reduce the natural ups and downs of eye pressure throughout the day in people with glaucoma. Researchers will measure eye pressure at three times during one day before the laser and again six months after. The goal is …

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study follows 60 children aged 7-12 for three years to measure their daily visual environment, including how far they look, light brightness and color, and eye movements. Researchers want to find which factors most influence the development and worsening of nearsightedness (…

This study aims to collect DNA samples and detailed eye exam data from 1,000 people with rare inherited eye diseases like aniridia, Best disease, and albinism. Participants provide a saliva or blood sample and share their eye health records. The goal is to expand a research repos…

This study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to collect detailed information from both the front and back of the e…

This study uses a one-time survey to learn about the eye and body symptoms of people with congenital aniridia, a rare genetic condition that affects the iris. Researchers want to see how much patients understand about their own disease. About 100 patients of all ages will take pa…

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This registry collects information from people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Participants share their symptoms, family history, and genetic test results online. The goal is to help researchers understand these rare diseases and …

This study will use advanced eye scans (OCT and OCTA) to compare the structure and blood flow of the choroid and retina in people with two main types of glaucoma: primary angle-closure disease and primary open-angle glaucoma. Researchers aim to better understand how these conditi…

This study is observing 300 children under 18 with uveitis, an eye inflammation condition. Researchers want to learn how common different types of uveitis are and what treatments children receive. Participants have one visit with their doctor, and some will have their medical rec…

This study uses a special camera called an adaptive optics scanning laser ophthalmoscope to take incredibly detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from healthy people and those with eye diseases like Star…

This study is tracking 290 children with non-infectious chronic uveitis, a rare eye inflammation that can cause vision loss. Researchers will collect data on symptoms, lab results, and complications over several years. The goal is to better understand the disease and identify ris…

This study aims to find new genes that may cause a hereditary risk for uveal melanoma, a rare eye cancer. Researchers will analyze the DNA of 50 patients with this cancer to identify unknown genetic changes. The goal is to improve screening and surveillance for families affected …

This study takes skin or blood cells from 20 people with eye malformations and turns them into stem cells, which are then grown into tiny 3D eye-like structures (organoids) in a dish. Researchers will study these mini eyes to understand what goes wrong during development and test…

This study follows 132 adults having glaucoma surgery to see how their quality of life changes over six months. Patients fill out a questionnaire about vision-related daily activities before and after surgery. The goal is to compare different surgical techniques from the patient'…

This study looks at how the liver's immune system reacts to a chemotherapy drug called melphalan, given directly to the liver through a special procedure. It involves 10 adults with uveal melanoma that has spread to the liver. The goal is to understand immune changes, not to test…

This study is looking for 500 people with certain cancers (like eye or skin melanoma, kidney cancer, or mesothelioma) and their family members to understand how common BAP1 gene mutations are. Researchers will collect medical history and questionnaires to learn about cancer risks…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to better understand its features and causes. Researchers will use imaging, vision tests, and quality-of-life surveys to track the disease over time. They will also analyze DNA to find…

This study is testing whether a special eye scan (OCT) can accurately measure inflammation inside the eye for people with uveitis. Researchers will scan the eyes of 1500 patients and compare the results to standard exams. The goal is to find a faster, painless way to track diseas…

This study aims to uncover genetic mutations or variations linked to uveitis, an inflammatory eye disease. Researchers will collect blood samples from 1,500 patients with uveitis (including infectious types) and analyze their DNA. The goal is to better understand what causes the …

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study tracks how choroidal melanoma and its treatment affect patients' quality of life. It involves 15 people already in a larger Phase 3 trial. Participants fill out questionnaires about their well-being over two years. No new drugs or procedures are tested here.

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This study looks at what happens to the back of your eye (the choroid) after you eat sugar. Healthy adults without diabetes will consume 30 grams of glucose tablets, and researchers will measure changes in choroidal thickness over time. The goal is simply to learn more about how …

This study looks at how short periods of high oxygen affect blood flow in the brains of ICU patients on breathing machines. Researchers will briefly increase the oxygen given through the ventilator and use ultrasound to monitor brain artery blood flow. The goal is to understand t…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study compares two common inhaled anesthetics, sevoflurane and desflurane, in 50 adults undergoing robotic-assisted abdominal surgery. Researchers will measure airway pressure to see which drug better protects lung function. The goal is to find the safer option for patients …

This study looks at two treatments made from patients' own blood—autologous serum and growth factor-rich plasma—to see which helps heal the cornea better in people with aniridia, a rare eye condition. Researchers will test these treatments on corneal cells in the lab, using blood…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This study looks at whether blood backing up in the veins during heart surgery can predict acute kidney injury. Researchers will monitor 114 adults having elective heart surgery, using ultrasound to check for venous congestion. The goal is to find an early warning sign to prevent…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study uses a special eye scan called OCT angiography to look at iris tumors in 100 people. Researchers want to see if this scan can tell the difference between harmless and cancerous growths better than current methods. Participants include people with iris tumors and health…

This study follows 700 people with uveal melanoma, a rare eye cancer, who are at high risk of the cancer spreading to the liver. Participants get regular liver MRIs and blood tests to look for early signs of metastasis. The goal is to see if personalized monitoring can detect rel…