New pill could help eye cancer patients keep their sight

NCT ID NCT07015190

Recruiting now Disease control Sponsor: IDEAYA Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests darovasertib, a daily pill, given before standard local therapy (radiation or surgery) for people with uveal melanoma that hasn't spread. The goal is to see if the drug can prevent vision loss and avoid eye removal. About 520 participants will be randomly assigned to receive darovasertib plus standard care or standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Darovasertib (a pill taken by mouth twice daily)
What this could lead to: If it works, this could offer a way to treat uveal melanoma while saving vision and the eye itself, reducing the need for eye removal.
What could go wrong: This is still an experimental drug, and it may not prove better than current standard care. Side effects from darovasertib are possible, and the study is open-label, which can introduce bias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

melanoma uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UVEAL MELANOMA

Contacts and locations

Locations

AHEPA University General Hospital of Thessaloniki
NOT_YET_RECRUITING

Thessaloniki, Thessaloníki, 546 36, Greece
ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco
NOT_YET_RECRUITING

Milan, Milan, 20157, Italy
Aarhus Universitetshospital
NOT_YET_RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Auckland Eye
NOT_YET_RECRUITING

Auckland, Auckland, 1050, New Zealand
Augusta Health, Center for Cancer and Blood Disorders
NOT_YET_RECRUITING

Fishersville, Virginia, 22939, United States
Austin Retina Associates - Central
RECRUITING

Austin, Texas, 78705, United States
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Tuscany, 50134, Italy
Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia
NOT_YET_RECRUITING

Perugia, Perugia, Italy
Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia
NOT_YET_RECRUITING

Pisa, 56124, Italy
CHU de Nice-Hôpital Pasteur
NOT_YET_RECRUITING

Nice, Alpes-Maritimes, 6000, France
CHU de Rennes - Hôpital Pontchaillou
NOT_YET_RECRUITING

Rennes, Ille-et-Vilaine, 35000, France
Centre Hospitalier National D'ophtalmologie Des Quinze Vingts
NOT_YET_RECRUITING

Paris, 75571, France
Centre Retine Gallien - Bordeaux
NOT_YET_RECRUITING

Bordeaux, Gironde, 33000, France
Charité - Universitätsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 12203, Germany
Clatterbridge Cancer Centre - Liverpool - NWCRN - PPDS
NOT_YET_RECRUITING

Metropolitan Borough of Wirral, Merseyside, CH63 4JY, United Kingdom
Clinica Universidad Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Cliniques Universitaires Saint-Luc - PPDS
RECRUITING

Brussels, 1200, Belgium
Cole Eye Institute-9500 Euclid Ave
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Cross Cancer Institute
NOT_YET_RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
East Tallinn Central Hospital-Pärnu road 104
NOT_YET_RECRUITING

Tallinn, Harju, 11312, Estonia
Erasmus MC
NOT_YET_RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Fakultna nemocnica s poliklinikou F. D. Roosevelta
NOT_YET_RECRUITING

Banská Bystrica, 975 17, Slovakia
Fondazione Policlinico Universitario A Gemelli - Rome - PPDS
NOT_YET_RECRUITING

Rome, 168, Italy
Gallipoli Medical Research Foundation
NOT_YET_RECRUITING

Greenslopes, Queensland, QLD 4120, Australia
Hadassah Medical Center - PPDS
RECRUITING

Jerusalem, Jerusalem, 91120, Israel
Hautklinik Erlangen
NOT_YET_RECRUITING

Erlangen, Bavaria, 91054, Germany
Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States
Hospital Clinico Universitario de Santiago
RECRUITING

Santiago de Compostela, A Coruña, 15706, Spain
Hospital Clinico Universitario de Valladolid
RECRUITING

Valladolid, Valladolid, 47003, Spain
Hospital Universitari i Politecnic La Fe de Valencia
NOT_YET_RECRUITING

Valencia, Valencia, 46026, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario de Bellvitge
NOT_YET_RECRUITING

L'Hospitalet de Llobregat, Barcelona, 8907, Spain
Institut Curie - Hôpital de Paris
NOT_YET_RECRUITING

Paris, Paris, 75248, France
Institute of Oncology Ljubljana
NOT_YET_RECRUITING

Ljubljana, Ljubljana, 1000, Slovenia
Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale
NOT_YET_RECRUITING

Naples, Campania, 80131, Italy
Jefferson Health Honickman Center
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Jules Stein Eye Institute
NOT_YET_RECRUITING

Los Angeles, California, 90024, United States
Kaiser Permanente-Riverside Medical Center
RECRUITING

Riverside, California, 92505-3043, United States
LKH-Universitätsklinikum Graz
NOT_YET_RECRUITING

Graz, 8036, Austria
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic - PPDS
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Scottsdale - PPDS
RECRUITING

Scottsdale, Arizona, 85259, United States
Memorial Sloan Kettering Cancer Center - 1275 York Ave
NOT_YET_RECRUITING

New York, New York, 10065-6635, United States
Moffit Cancer Center
NOT_YET_RECRUITING

Tampa, Florida, 33612, United States
Northwell Health Cancer Institute
NOT_YET_RECRUITING

New York, New York, 11042, United States
Ohio State Eye and Ear Institute
NOT_YET_RECRUITING

Columbus, Ohio, 43212, United States
PAGNI-University General Hospital of Heraklion
NOT_YET_RECRUITING

Heraklion, Irakleio, 715 00, Greece
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Retina Consultants of Oklahoma
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Retina Consultants of Texas - (Houston)
NOT_YET_RECRUITING

Houston, Texas, 77030-2727, United States
Rigshospitalet
NOT_YET_RECRUITING

Copenhagen O, Capital, 2100, Denmark
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Stanford Comprehensive Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Städtisches Klinikum Dessau
NOT_YET_RECRUITING

Dessau, Saxony-Anhalt, 6847, Germany
TIERING Percentiles
NOT_YET_RECRUITING

Omaha, Nebraska, 68105, United States
Texas Retina Associates - Dallas
RECRUITING

Dallas, Texas, 75231, United States
The Alfred Hospital
NOT_YET_RECRUITING

Melbourne, Victoria, 3004, Australia
The Cancer and Hematology Centers of West Michigan (CHCWM)
RECRUITING

Grand Rapids, Michigan, 49503, United States
The Chaim Sheba Medical Center - PPDS
RECRUITING

Ramat Gan, Central District, 5262100, Israel
The Crown Princess Mary Cancer Centre (Westmead Hospital), NSW 214
NOT_YET_RECRUITING

Westmead, NSW 2145, Australia
The Melanoma and Skin Cancer Institute
NOT_YET_RECRUITING

Englewood, Colorado, 80113-2791, United States
The Queen Elizabeth Hospital
NOT_YET_RECRUITING

Woodville South, South Australia, 5011, Australia
UCSD Moores Cancer Center
NOT_YET_RECRUITING

La Jolla, California, 92093, United States
UCSF Wayne and Gladys Valley Center for Vision
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
UPMC Hillman Cancer Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USC Norris Comprehensive Cancer Center
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
USF Health Eye Institute
NOT_YET_RECRUITING

Tampa, Florida, 33612-6601, United States
UZ Leuven - PPDS
NOT_YET_RECRUITING

Leuven, 3000, Belgium
University College Hospital
NOT_YET_RECRUITING

London, NW1 2BU, United Kingdom
University General Hospital of Larissa
NOT_YET_RECRUITING

Larissa, Larissa, 41 110, Greece
University of California Irvine Medical Center
NOT_YET_RECRUITING

Orange, California, 92868, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Texas Southwestern Medical Center-5323 Harry Hines Blvd
RECRUITING

Dallas, Texas, 75390-9057, United States
University of Wisconsin Health
NOT_YET_RECRUITING

Madison, Wisconsin, 53705-3644, United States
Universitätsklinikum AKH Wien
NOT_YET_RECRUITING

Vienna, 1090, Austria
Universitätsklinikum Bonn
NOT_YET_RECRUITING

Bonn, 53127, Germany
Universitätsklinikum Essen
NOT_YET_RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
Universitätsklinikum Giessen und Marburg - Marburg (UKGM)
NOT_YET_RECRUITING

Marburg, 35043, Germany
Universitätsklinikum Innsbruck
NOT_YET_RECRUITING

Innsbruck, 6020, Austria
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
NOT_YET_RECRUITING

Lübeck, 23562, Germany
Universitätsklinikum Tübingen
NOT_YET_RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitätsklinikum Ulm
NOT_YET_RECRUITING

Ulm, Baden-Wurttemberg, 89075, Germany
Universitätsklinikum Würzburg
NOT_YET_RECRUITING

Würzburg, 97080, Germany
Universitätsspital Basel
RECRUITING

Basel, 4031, Switzerland
Universitätsspital Zürich
RECRUITING

Zurich, 8091, Switzerland
Uniwersytecki Szpital Kliniczny w Poznaniu- Dluga 1/2
NOT_YET_RECRUITING

Poznan, Greater Poland Voivodeship, 61-848, Poland
Uniwersyteckie Centrum Kliniczne w Gdansku - Debinki 7
NOT_YET_RECRUITING

Gdansk, Pomeranian Voivodeship, 80-214, Poland
Ustredni vojenska nemocnice - Vojenska fakultni nemocnice Praha
RECRUITING

Prague, Prague, 169 02, Czechia
Vanderbilt Eye Institute
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
W Kellogg Eye Center
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48105, United States
WIM-PIB, Centralny Szpital Kliniczny MON
NOT_YET_RECRUITING

Warsaw, Masovian Voivodeship, 04-141, Poland
Weston Park Cancer Centre - PPDS
NOT_YET_RECRUITING

Sheffield, S10 2TF, United Kingdom
Wilmer Eye Institute
RECRUITING

Baltimore, Maryland, 21287-0005, United States

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