New hope: eye injections may stop Radiation-Related blindness

NCT ID NCT05844982

Recruiting now Prevention Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether two different eye treatments can prevent vision loss in people who have had radiation therapy for a type of eye cancer called uveal melanoma. The study will compare faricimab injections given every 3 months, a fluocinolone acetonide implant placed in the eye, and simple observation. About 600 participants will be followed to see if these treatments help maintain vision over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: faricimab and fluocinolone acetonide
What this could lead to: If successful, this could offer a way to prevent vision loss in people who have had radiation therapy for eye cancer.
What could go wrong: This is a large phase 3 trial, but it is still experimental. The treatments may not prevent vision loss and could have side effects like eye inflammation or increased eye pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant choroid melanoma vision disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RADIATION RETINOPATHY VISUAL IMPAIRMENT

Contacts and locations

Locations

Associated Retinal Consultants, P.C.
RECRUITING

Royal Oak, Michigan, 48073, United States
Byers Eye Institute at Stanford University
RECRUITING

Palo Alto, California, 94303, United States
Emory Eye Center
RECRUITING

Atlanta, Georgia, 30322, United States
Foundation for Vision Research and Retina Specialists of Michigan, P.C.
RECRUITING

Grand Rapids, Michigan, 49546, United States
IL Eye and Ear Infirmary-University of Illinois at Chicago
RECRUITING

Chicago, Illinois, 60612, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Midwest Eye Institute
RECRUITING

Indianapolis, Indiana, 46290, United States
Northwestern Memorial Group
RECRUITING

Chicago, Illinois, 60611, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Pittsburgh Clinical Trial Consortium
RECRUITING

Sewickley, Pennsylvania, 15143, United States
Retina Associates of Florida, LLC
RECRUITING

Tampa, Florida, 33609, United States
Retina Consultants
RECRUITING

Manchester, Connecticut, 06042, United States
Retina Consultants of Carolina, PA
RECRUITING

Greenville, South Carolina, 29605, United States
Retina Consultants of Texas, PA
RECRUITING

Bellaire, Texas, 77401, United States
Retina Research Institute, LLC
RECRUITING

St Louis, Missouri, 63128, United States
Retina-Vitreous Consultants, Inc.
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Southeastern Retina Associates
RECRUITING

Hixson, Tennessee, 37343, United States
Tennessee Retina, PC
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Retina Associates
RECRUITING

Lubbock, Texas, 79424, United States
The Board of Regents of the University of Wisconsin System
RECRUITING

Madison, Wisconsin, 53705, United States
The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine
RECRUITING

Celveland, Ohio, 44120, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Iowa Department of Ophthalmology and Visual Sciences
RECRUITING

Iowa City, Iowa, 52242, United States
Washington University Ophthalmology
RECRUITING

St Louis, Missouri, 63110, United States
Wills Eye Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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