New hope for rare eye cancer: experimental combo takes on standard therapy
NCT ID NCT06581406
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 24 times
Summary
This study tests whether a new drug called RP2, given with nivolumab, works better than the standard combo of ipilimumab and nivolumab for people with metastatic uveal melanoma (eye cancer that has spread). About 280 adults who haven't had immune therapy before will receive injections directly into tumors plus infusions. The goal is to see if the new combo helps people live longer or slows cancer growth.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Emory Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Georgetown University Medical Center
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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HonorHealth Research Insisute
RECRUITINGScottsdale, Arizona, 85258, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic - Jacksonville FL
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Melanoma Institute Australia
RECRUITINGWollstonecraft, New South Wales, 2065, Australia
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
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Peter MacCallum Cancer Centre
RECRUITINGMelbourne, Victoria, 3000, Australia
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Sarah Cannon Research Institute
RECRUITINGNashville, Tennessee, 37203, United States
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Stanford Cancer Institute
RECRUITINGPalo Alto, California, 94304, United States
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Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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The Angeles Clinic and Research Institute
RECRUITINGLos Angeles, California, 90025, United States
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The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITINGLiverpool, Merseyside, L7 8YA, United Kingdom
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The Melanoma & Skin Cancer Institute
RECRUITINGEnglewood, Colorado, 80113, United States
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The Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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The Royal Marsden NHS Foundation Trust
RECRUITINGLondon, SW3 6JJ, United Kingdom
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The University Of Texas Md Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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The West Clinic, PLLC dba West Cancer Center
RECRUITINGGermantown, Tennessee, 38138, United States
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Thomas Jefferson University
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92037, United States
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UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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University Of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
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University of California Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Colorado Hospital - Anschutz Cancer Pavilion(ACP)
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Tennessee Medical Center
RECRUITINGKnoxville, Tennessee, 37920, United States
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Vanderbilt Ingram Cancer Center (Henry-Joyce Cancer Clinic)
RECRUITINGNashville, Tennessee, 37232, United States
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Conditions
Explore the condition pages connected to this study.