New hope for rare eye cancer: experimental combo aims to shrink tumors and extend life

NCT ID NCT06581406

Recruiting now Disease control Sponsor: Replimune, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new drug called RP2, given with nivolumab, works better than the current standard combination (ipilimumab plus nivolumab) for people with metastatic uveal melanoma, a rare eye cancer that has spread. About 280 adults who have not had prior immunotherapy will receive either the new or standard treatment. The goal is to see if the new combo helps people live longer or keeps the cancer from growing.

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Conditions

The condition(s) this trial relates to.

melanoma Neoplasm Metastasis uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC UVEAL MELANOMA

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
HonorHealth Research Insisute
RECRUITING

Scottsdale, Arizona, 85258, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic - Jacksonville FL
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Melanoma Institute Australia
RECRUITING

Wollstonecraft, New South Wales, 2065, Australia
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Stanford Cancer Institute
RECRUITING

Palo Alto, California, 94304, United States
Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
The Angeles Clinic and Research Institute
RECRUITING

Los Angeles, California, 90025, United States
The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, Merseyside, L7 8YA, United Kingdom
The Melanoma & Skin Cancer Institute
RECRUITING

Englewood, Colorado, 80113, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University Of Texas Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The West Clinic, PLLC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University Of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States
University of California Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado Hospital - Anschutz Cancer Pavilion(ACP)
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States
Vanderbilt Ingram Cancer Center (Henry-Joyce Cancer Clinic)
RECRUITING

Nashville, Tennessee, 37232, United States

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