Immune cell therapy shows promise against rare eye cancer
NCT ID NCT03467516
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether a patient's own immune cells, called tumor-infiltrating lymphocytes (TIL), can shrink tumors in people with metastatic uveal melanoma, a rare and aggressive eye cancer. Participants receive chemotherapy to prepare their immune system, then an infusion of their own TIL cells followed by high-dose aldesleukin (IL-2). The study aims to confirm earlier promising results showing tumor shrinkage and durable responses in some patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tumor Infiltrating Lymphocytes (TIL) plus high-dose aldesleukin (IL-2)
What this could lead to
If successful, this could offer a new treatment option for a rare and aggressive eye cancer that currently has no effective standard therapy.
What could go wrong
This is a small, early-phase trial (34 patients) and the treatment involves intensive chemotherapy and high-dose IL-2, which can cause serious side effects. Results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States