Radioactive drug targets Hard-to-Treat melanoma in early trial

NCT ID NCT07076550

Recruiting now Disease control Sponsor: Alpha-9 Oncology USA Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a radioactive drug called [225Ac]Ac-A9-3408 in 50 adults with melanoma that has spread or can't be removed by surgery. The main goals are to find a safe dose and check for side effects. Participants receive the drug every 6 weeks for up to 6 doses, and doctors will also see if tumors shrink.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A radioactive drug called [225Ac]Ac-A9-3408 given by IV
What this could lead to: If it works, this could point toward a new treatment option for advanced melanoma that has spread or cannot be removed by surgery.
What could go wrong: This is an early Phase 1 trial with only 50 people, so safety and effectiveness are not yet known. The drug is radioactive and may cause side effects; it is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MELANOMA METASTATIC are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma metastatic melanoma mucosal melanoma Neoplasm Metastasis uveal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA METASTATIC MUCOSAL MELANOMA UVEAL MELANOMA, METASTATIC

Contacts and locations

Locations

Alfred Health
RECRUITING

Melbourne, Victoria, 3004, Australia
Austin Health
RECRUITING

Melbourne, Victoria, 3084, Australia
Fiona Stanley Hospital
NOT_YET_RECRUITING

Murdoch, Western Australia, 6150, Australia
GenesisCare Murdoch
NOT_YET_RECRUITING

Murdoch, Western Australia, 6150, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.