Posterior uveitis

This study tests a new drug, GenSci048, in people with active non-infectious uveitis, an inflammatory eye disease. The trial will compare two doses of GenSci048 against a placebo to see if it can control the disease and reduce treatment failure. About 111 adults with active uveit…

This study tests the drug adalimumab (Tebiovio®) in 30 adults with non-infectious uveitis, an inflammatory eye disease. The goal is to see if the drug can control inflammation and prevent treatment failure. Participants will receive injections and be monitored for up to 24 weeks.…

This study tests whether faricimab (Vabysmo), an FDA-approved eye injection for other retinal diseases, can safely treat abnormal blood vessel growth in the eye caused by presumed ocular histoplasmosis syndrome. About 25 adults with this condition will receive an initial injectio…

This study tests a new treatment called LB-DTK-CMV for people with cytomegalovirus (CMV) retinitis that has not responded to standard antiviral medicines. The treatment uses a patient's own immune cells, specially trained to attack CMV, and is given as two infusions. The trial ai…

This study tests an oral medication called FXS5626 in 40 adults with active non-infectious uveitis, a condition causing inflammation inside the eye. The goal is to see if the drug can control the disease better than a placebo, reducing the need for other treatments. Participants …

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study is observing 300 children under 18 with uveitis, an eye inflammation condition. Researchers want to learn how common different types of uveitis are and what treatments children receive. Participants have one visit with their doctor, and some will have their medical rec…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to better understand its features and causes. Researchers will use imaging, vision tests, and quality-of-life surveys to track the disease over time. They will also analyze DNA to find…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …