ST-elevation myocardial infarction

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This study tests whether a single dose of rituximab, a drug that calms the immune system, can help the heart pump better six months after a severe type of heart attack called an anterior STEMI. About 372 adults who have just had such an attack will receive either rituximab or a p…

This trial tests whether fexofenadine, a common allergy medication, can help the heart heal better after a severe type of heart attack called STEMI. Participants will receive either fexofenadine or a placebo for six months, alongside standard care, after undergoing a procedure to…

This study is testing whether fexofenadine, a common allergy medication, can reduce the risk of serious heart and brain events in people who have recently had a heart attack. About 2,800 participants will receive either fexofenadine or a placebo for 24 months. The goal is to see …

This study looks at the best timing for opening blocked arteries in people having a certain type of heart attack (NSTEMI) who have multiple blockages. About 1,014 participants will be randomly assigned to have all blockages fixed during the same procedure or to wait a few days be…

This study looks at whether heart attack patients with mild artery narrowing can be treated with medication alone instead of getting a stent. About 2,000 people will be randomly assigned to either standard medication or medication plus a stent. The goal is to see if medication al…

This study tests a new medicine called SGC001 in people who have had a serious type of heart attack (anterior STEMI) and are scheduled for a procedure to open blocked arteries. The goal is to see if SGC001 can reduce the size of the heart damage and lower the chance of future hea…

This trial tests whether a noninvasive procedure called RE-START, which uses a blood pressure cuff to temporarily stop blood flow in the arm, can improve blood flow in the heart's arteries before standard angioplasty in people having a severe heart attack (STEMI). The study invol…

This trial tests whether using a suction catheter to remove large blood clots before placing a stent improves outcomes in people having a severe heart attack (STEMI). Participants must have a large clot visible on angiography. Half receive standard stent placement alone, and half…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This study looks at people who have had a severe type of heart attack called STEMI. It compares a shorter course (about one month) of two blood thinners followed by just one drug (prasugrel) for a year, versus the standard one-year regimen of two blood thinners. The goal is to se…

This study looks at giving a blood thinner called heparin to heart attack patients as soon as they see a doctor, rather than waiting until they are in the procedure room. About 6,294 participants will be randomly assigned to early or standard timing. The goal is to see if early t…

This study tests whether adding the blood thinner rivaroxaban (Xarelto) to standard care helps dissolve dangerous blood clots in the heart after a major heart attack. Researchers will track 320 participants to see if the drug reduces strokes and other complications. The goal is t…

This study compares a new approach using fewer stents and a drug-coated balloon to the standard method of placing stents in heart attack patients. About 1,272 participants will be randomly assigned to one of the two treatments. The goal is to see if the reduced-stent strategy low…

This study compares two drugs given directly into the heart arteries during a heart attack: rhTNK-tPA, a clot dissolver, and tirofiban, a blood thinner. Researchers will enroll 300 patients with severe blockages to see which drug restores blood flow better and causes fewer bleedi…

This study tracks 1,000 heart attack patients to see if adding SuperSaturated Oxygen therapy to standard angioplasty reduces heart muscle damage and improves outcomes. Participants are adults aged 18-80 who had a specific type of heart attack. The goal is to learn if this extra t…

This study compares two ways to guide stent placement during a heart attack: standard angiography (X-ray) versus a more detailed imaging method called optical coherence tomography (OCT). The goal is to see if OCT leads to fewer future heart problems, like repeat blockages or hear…

This study tests whether giving the drug adenosine just before emergency angioplasty (PCI) can improve blood flow in heart attack patients. About 1,148 adults having a severe type of heart attack (STEMI) will either receive adenosine or standard care. The goal is to see if adenos…

This study tests whether using a special catheter to remove blood clots during emergency heart attack treatment can reduce heart muscle damage. About 140 patients having a major heart attack will be randomly assigned to get either standard care or standard care plus clot removal.…

This phase 3 trial tests whether a single high dose of the steroid methylprednisolone, given in the ambulance before opening the blocked artery, can reduce deaths in people having a major heart attack (STEMI). About 5,200 adults will be randomly assigned to receive either the ste…

This study compares two blood-thinning approaches in 326 adults with acute coronary syndrome and coronary artery ectasia (enlarged heart arteries). One group gets standard dual antiplatelet therapy (aspirin plus clopidogrel), while the other gets clopidogrel plus the anticoagulan…

This study tests a special balloon procedure called ischemic postconditioning in 1800 people having a heart attack. After opening the blocked artery, doctors briefly inflate and deflate a balloon four times to see if it reduces heart damage. The goal is to lower the chance of hea…

This study tests two methods used during emergency heart attack treatment: ischemic postconditioning (briefly pausing blood flow after opening the artery) and ultrasound-guided stent placement. The goal is to see if these techniques reduce death, heart failure, or the need for an…

This study tests if a drug-coated balloon works as well as the standard drug-coated stent for opening blocked arteries during a heart attack. About 600 adults having a severe type of heart attack (STEMI) will be randomly assigned to one of the two treatments. The goal is to see w…

This study tests whether a new medicine called ziltivekimab can reduce fatty plaque buildup in heart arteries after a heart attack. About 332 participants will receive either the drug or a placebo for 15 months. The goal is to see if the drug helps control artery disease and prev…

This study tests whether the drug ranolazine can protect the tiny blood vessels in the heart after a heart attack. One hundred adults who had a major heart attack and have at least one other blocked artery will receive either ranolazine plus standard care or standard care alone. …

This study looks at whether empagliflozin, a medicine used for diabetes, can help blood vessels and heart muscle recover after a heart attack. About 80 people who had a severe heart attack will either receive empagliflozin or standard care. Researchers will measure artery stiffne…

This study tests whether taking only the blood thinner ticagrelor (instead of the usual combination of ticagrelor plus aspirin) can reduce bleeding after a heart attack. It involves 2,570 adults who had a heart attack but did not receive stents or bypass surgery. Participants wil…

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This trial studies whether removing blood clots from heart arteries during angioplasty improves outcomes for people who have had a major heart attack. 3500 participants will be randomly assigned to get either clot removal plus angioplasty or angioplasty alone. The main goal is to…

This study tests using a drug-coated balloon instead of a permanent stent to open blocked arteries during a heart attack. The balloon delivers medication to prevent re-blockage without leaving a metal implant. Researchers will track 300 participants to see if this approach is saf…

This study tests whether a personalized nutrition program, supported by digital tools like meal plans and remote guidance, can improve heart function in people who recently had a severe heart attack (STEMI). Two hundred participants will follow the program for three months, and d…

This study tests whether dapagliflozin, a diabetes drug, can limit heart muscle damage in people having a major heart attack (STEMI). Participants receive either the drug or a placebo for 7 days, and heart damage is measured with an MRI. The goal is to see if this drug can improv…

This study tests a new drug-coated stent and a blood thinner strategy without aspirin for people who have had a severe heart attack. The goal is to see if this approach lowers the risk of serious bleeding while still preventing future heart attacks, strokes, or the need for anoth…

This study tests if a drug-coated balloon works as well as a drug-coated stent for people having a severe heart attack (STEMI). About 1,200 participants will receive either the balloon or the stent during emergency artery-opening procedures. The goal is to see if the balloon, whi…

This study looks at whether giving a PCSK9 inhibitor (alirocumab) soon after a heart attack can help save more heart muscle. About 160 adults having a specific type of heart attack will either get the drug or standard care. The main goal is to see if the drug improves heart muscl…

This phase 3 trial tests whether montelukast, a common asthma drug, can reduce heart damage in people having a heart attack. 512 patients with a specific type of heart attack will receive either montelukast or a placebo daily for 3 months. The goal is to see if the drug prevents …

This pilot study tests whether two diabetes drugs—dapagliflozin and semaglutide—can reduce inflammation after a heart attack. Researchers will enroll 44 people with type 2 diabetes, obesity, and high inflammation levels. Participants will take one of the drugs for 24 weeks, and t…

This study tests two diabetes medications (SGLT2 inhibitors and GLP-1 agonists) to see if they can reduce epicardial fat—the fat around the heart—in people who recently had a heart attack. About 136 participants with type 2 diabetes and obesity will have their heart fat measured …

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This study tests whether a single injection of morphine around certain neck nerves can reduce heart muscle damage after a heart attack. About 166 adults who have had a severe heart attack and undergone artery-opening treatment will receive either morphine or a saltwater placebo. …

This study tests a new way to reduce heart damage after a severe heart attack (STEMI). Doctors will cool the heart's arteries during the standard procedure to open blocked vessels. The goal is to see if this cooling prevents further injury and improves heart function. The trial i…

This study compares a drug-coated balloon to a standard drug-eluting stent in 496 young adults (ages 18–50) having a heart attack. The balloon delivers medication to open the artery without leaving a permanent implant, which may reduce long-term risks like blood clots and the nee…

This study tests an experimental drug called RTP-026 in 96 adults who have had a severe type of heart attack (STEMI). Participants receive three short infusions of the drug or a placebo. The goal is to see if RTP-026 can reduce heart muscle damage, measured by blood markers. The …

This study tests whether an artificial intelligence (AI) mobile app can help doctors give clot-busting medicine earlier to people having a severe heart attack (STEMI) when a hospital procedure isn't possible within 2 hours. About 3,356 participants will be randomly assigned to ge…

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This study explores a new blood test that looks for DNA fragments from damaged heart cells to detect active heart inflammation in people with sarcoidosis. Researchers will compare results from 120 participants, including healthy volunteers and those with known heart conditions. I…

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study tests whether watching nature videos through virtual reality glasses can lower anxiety and improve vital signs like heart rate and blood pressure in people recovering from a heart attack in the intensive care unit. Half of the 50 participants will use VR glasses for a …

This study looks at how certain white blood cells, called monocytes, react to injury from a heart attack or ischemic stroke. Researchers want to learn how these cells sense danger signals and produce substances that might help heart muscle and brain tissue heal. The study involve…

This study investigates whether the types and behavior of certain immune cells (neutrophils and monocytes) in the blood are linked to how the heart repairs itself after a heart attack. Researchers will follow 50 adults who have had a severe type of heart attack and are scheduled …

This study looks at whether combining a new type of CT scan with a blood test for tiny molecules called microRNAs can better predict heart damage after a heart attack. Researchers will follow 95 patients who had a severe heart attack and measure changes in their heart size over s…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study is a large registry that will collect information from 10,000 adults who undergo exercise echocardiography (a heart ultrasound during exercise) as part of their regular care. The goal is to better understand how the heart works during exercise in people with various he…

This study is following 300 people who have had a severe type of heart attack (STEMI). Researchers will collect blood, urine, and stool samples, and perform MRI scans to look for new biological and imaging markers that could help predict long-term outcomes. The goal is to better …

This study examines how frailty and other health factors affect the short- and long-term outlook for people aged 75 and older who are hospitalized for a heart attack or unstable angina. Researchers will compare two treatment approaches—a procedure to open blocked arteries versus …

This study is looking for clues in the blood that could predict if a person's heart will change shape or develop serious problems after a major heart attack. Researchers will collect blood samples and perform heart ultrasounds on 1,000 patients over six months. The goal is to fin…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study looks at whether people who have a heart attack can be discharged from the hospital after about 24 hours instead of the usual 36 hours or more. Researchers want to see if early discharge is just as safe and does not increase the risk of death, another heart attack, or …

This study follows 20,000 heart attack patients who are discharged early from the hospital after a minimally invasive procedure. Researchers want to see how well medications are adjusted, track major heart events, and measure quality of life over one year. No new treatment is giv…

This study tracks 1,650 people who had a first heart attack to see if men and women's hearts change shape and size differently during recovery. Using repeated heart scans (echocardiograms and MRIs), researchers aim to understand why women tend to have worse outcomes like heart fa…

This study looks at 200 people having a heart attack to see if a special camera (OCT) inside the arteries correctly identifies the type of plaque that caused the attack. Researchers will compare the camera images with the actual plaque material removed during a standard procedure…

This study is following 1,000 people who have had a severe type of heart attack called STEMI. Researchers are collecting detailed medical data to understand how different organs talk to each other during recovery. The goal is to find key signals that could lead to better treatmen…

This observational study enrolls 5,000 adults hospitalized with acute coronary syndrome in Italy. Researchers will track how often doctors follow European quality indicators, like timely artery-opening procedures and proper discharge medications. Participants are followed for 12 …

This study uses a special type of MRI called diffusion tensor imaging to look at the structure of heart muscle in people with heart failure, recent heart attacks, or thickened heart walls. Researchers want to see how the heart's muscle fibers change over time, which may help expl…

This study looks at whether giving the beta-blocker landiolol early, during a heart attack, can reduce the amount of heart muscle that dies. It will follow 100 patients who get either landiolol or a standard oral beta-blocker, based on their doctor's choice. The main goal is to m…

This study reviews medical records of 200 adults who came to the ER with a heart attack or unstable chest pain. It compares what happens when patients get two blood thinners (aspirin plus another) in the ER versus waiting to give the second one in the catheterization lab. The goa…

This study looks at 1,600 people who recently had a heart attack to see if a common blood test (the neutrophil-to-lymphocyte ratio, or NLR) can help predict who is at higher risk of dying or having another heart problem within 6 months. Researchers will measure NLR from blood sam…

This study looks at 320 people who had a severe heart attack (STEMI) and have blockages in other arteries besides the one that caused the attack. Researchers will use CT scans and blood tests to see which blockages are likely to cause future problems. The goal is to find out if o…