Prediabetes syndrome

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This phase 2 trial tests whether a low dose of everolimus, a drug used in cancer, can safely improve signs of aging in 106 adults aged 55-80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in met…

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study aimed to see if an 8-week low-calorie diet (about 1,300 calories per day) could reverse isolated impaired fasting glucose, a form of prediabetes, in overweight adults aged 35 to 65. Participants would have received pre-prepared meals and been monitored for changes in b…

This study looks at whether eating proteins and vegetables before carbohydrates (meal sequencing) can improve blood sugar control in 70 adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrit…

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This study tests whether eating dried Saskatoon berries daily for 10 weeks can improve blood sugar and cholesterol levels in people with untreated prediabetes or new type 2 diabetes. Researchers will compare the effects of Saskatoon berries to a control dried fruit in 92 adults a…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This study tests whether giving people free boxes of fruits and vegetables along with nutrition education can improve health in three Mississippi counties with high rates of diabetes, obesity, and poverty. About 300 adults with high blood sugar or obesity will receive produce and…

This study looked at whether time-restricted eating (eating only during a set window each day) helps overweight or obese people with prediabetes return to normal blood sugar levels. Over 12 months, 142 participants either followed this eating pattern or received standard care. Th…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study compares a new diabetes-specific nutritional formula to an existing one in 103 adults with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. The goal is to see if the new formula is as good as the current one at improving nutrition, mea…

This study tests whether probiotics can control blood sugar as well as metformin in people with prediabetes. Thirty adults aged 31-60 with prediabetes will take either probiotics or metformin for 13 weeks. The goal is to see if probiotics offer a new treatment option to prevent t…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study tests whether a device that gently stimulates the vagus nerve through the ear can improve how the body handles sugar and affect mood in people with obesity and prediabetes. Seventy participants will use the device for 45 minutes, three times a week for three months. Th…

This study looks at 4,000 adults with prediabetes and heart disease to see if a low-intensity statin combined with ezetimibe is better than a high-intensity statin alone at preventing new diabetes. Participants will be followed to track diabetes development and heart health. The …

This study tests whether a personalized lifestyle plan focused on improving diet, exercise, and sleep according to the body's natural rhythms can lower blood sugar levels in older adults. Sixteen participants aged 50-80 with elevated blood sugar and a long daily eating window wil…

This study was designed to test whether metformin, a common diabetes drug, could improve blood vessel function in people with prediabetes. It planned to enroll adults aged 18-55 with prediabetes and compare metformin to a placebo over 12 weeks. However, the study was withdrawn be…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study looks at whether doing resistance exercise with different levels of effort can improve blood sugar control in people with prediabetes. 48 adults aged 18 to 75 with prediabetes will be assigned to either high-effort or low-effort resistance training. Researchers will me…

This pilot study looks at whether a home exercise program plus a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. The study will enroll 20 people a…

This study tests whether eating 1.5 cups of fresh mango daily for 12 weeks can improve blood sugar, cholesterol, and inflammation in people with prediabetes. Thirty-one participants will eat mango for 12 weeks, then take a break, and then avoid mango for another 12 weeks. Researc…

This study tests two plant-based supplement blends in 87 overweight adults with prediabetes. Over 12 weeks, researchers measure changes in blood sugar markers like HbA1c and post-meal glucose. The goal is to see if these natural extracts can help manage blood sugar levels.

This study is testing whether an artificial intelligence (AI) program can spot early signs of diabetic retinopathy—a condition that can lead to blindness—in people with prediabetes and diabetes. Researchers will take pictures of the retina and use the AI to analyze them. The goal…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This study tests whether a 6-week cooking education program can help prevent type 2 diabetes in adults who are at risk or have prediabetes, especially in underrepresented minority communities. Participants take cooking classes and some wear a continuous glucose monitor. The goal …

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can safely prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will first try lifestyle changes alone for 12 weeks, then add metfo…

This pilot study tests whether pharmacist-led lifestyle education, wellness tools, and healthcare referrals can help hospitality workers in New Orleans prevent diabetes. About 300 adults with prediabetes or high risk will take part for one year. The goal is to see if this approac…

This study tests whether the BCG vaccine, normally used for tuberculosis, can prevent type 2 diabetes in people with pre-diabetes. Researchers in Guinea-Bissau will give two doses of BCG or a placebo to 200 adults and track their blood sugar levels. The goal is to see if the vacc…

This study tests a web application called VA|PREVENTION that uses a virtual coach to help adults at high risk for type 2 diabetes make healthier choices. 180 participants will either use the app or receive a standard guidebook. Researchers will measure changes in waist circumfere…

This study tests a program called "Paso a Paso" designed to help Spanish-speaking adults at risk for diabetes. About 45 participants will take part to see if the program is practical and effective. The goal is to prevent diabetes by helping people lose weight and manage blood sug…

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet improves blood sugar control better than diet alone in women with prediabetes. Thirty women will be split into three groups based on their current blood sugar levels. They will follow the die…

This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 high-risk adults in China. Participants take berberine or a placebo twice daily, plus receive lifestyle advice. The study tracks blood sugar and heart …

This study looks at whether a diabetes prevention program delivered via telehealth works as well as the same program done in person for adults aged 65 and older with prediabetes. About 238 participants will be randomly assigned to either a telehealth or in-person group, and resea…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests whether adding peer support and healthy food vouchers to a standard diabetes prevention program helps low-income adults with prediabetes stick with the program and lower their risk of developing type 2 diabetes. About 142 participants will either get the standard…

This study tests whether easy-to-use tools like a decision aid and text messages can encourage people with prediabetes to take proven steps—like joining a lifestyle program or taking metformin—to prevent type 2 diabetes. Nearly 1,000 adults from primary care clinics are taking pa…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

This study looks at how dried figs affect blood sugar and insulin in adults with pre-diabetes. Five participants will eat figs or a calorie-matched control breakfast, and researchers will measure blood glucose, insulin, and fig polyphenol levels over 24 hours. The goal is to see …

This study tests whether an 8-week nutrition education program focused on fiber-rich foods (like fruits, vegetables, and whole grains) is acceptable and helpful for people with diabetes, prediabetes, or obesity. Researchers will track participants' weight and dietary changes over…

This study was designed to see if two drugs, empagliflozin and anakinra, could help people with prediabetes who experience low blood sugar after eating. The trial planned to give a single dose of each drug before a test meal and measure symptoms. However, the study was withdrawn …

This study surveys 500 doctors in Egypt to see how well they understand prediabetes—a condition where blood sugar is high but not yet diabetic. Doctors answer questions about risk factors, diagnostic tests, and lifestyle recommendations. The goal is to find gaps in knowledge that…

This study looks at whether two common artificial sweeteners, saccharin and acesulfame potassium, affect blood sugar control in older adults with prediabetes. Researchers will monitor 30 participants over 8 weeks using continuous glucose monitors and oral glucose tolerance tests.…

This pilot study looks at how environmental stress affects daily blood sugar changes in 30 Hispanic adults whose parent has type 2 diabetes. Researchers use continuous glucose monitors to track glucose and aim to design a future program to prevent diabetes. The study does not tes…

This pilot study tests a digital tool that doctors use during visits to help patients with prediabetes become more active in managing their health. The tool asks patients a few questions and then gives the doctor tips on how to talk about lifestyle changes and resources like heal…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study looks at how aging changes the way older adults respond to exercise. Researchers will have 26 people who previously completed a structured exercise program do a 6-month aerobic workout. They will measure changes in insulin sensitivity and heart fitness to see if age af…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study is testing whether wearable devices like continuous glucose monitors and the Oura Ring can help predict how well the pancreas is working in people with prediabetes or type 2 diabetes. The goal is to develop remote tools that allow personalized treatment to preserve ins…

This study looks at whether routine blood sugar testing during dental checkups can help find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe gum disease will get a simple finger-prick blood test during their dental visit. The goal is to s…

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at how sleep apnea might cause prediabetes to turn into diabetes. Researchers will use CPAP machines and niacin infusions in 300 overweight, prediabetic adults with sleep apnea to measure changes in blood chemicals. The goal is to understand the biological steps …

This study looks at how fructose in meals influences fat production and blood sugar levels in people with prediabetes or insulin resistance. Researchers will give participants special labeled fructose or pyruvate in liquid meals to track these processes. The goal is to better und…

This study aimed to see if adding pramlintide to semaglutide (Wegovy) could change appetite and eating habits in obese people with prediabetes. It also tried to find ways to predict who would respond best to obesity medication. The trial was withdrawn before any participants were…

This study was designed to see if adding the amino acid isoleucine to a healthy, low-isoleucine diet would change how the body responds to insulin in people with obesity and prediabetes. It planned to enroll adults with a BMI of 30 or higher who also had metabolic syndrome. The s…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study was designed to see if a high-intensity interval training (HIIT) program is feasible and acceptable for adults aged 35-65 with overweight and slightly high fasting blood sugar (impaired fasting glucose). It planned to enroll 34 physically inactive participants and meas…

This study looks at how not having reliable access to enough food might make it harder to lose weight. Researchers are giving 12 women who face food insecurity and have obesity and prediabetes a steady supply of healthy, low-calorie meals for a period. They will measure changes i…

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study looks at how eating whole wheat bread affects gut bacteria and health in adults with prediabetes. 65 participants will eat either whole wheat or white bread for two weeks, then provide stool, urine, and blood samples. The goal is to see if whole wheat can improve blood…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study follows 300 adults with diabetes, prediabetes, or overweight who fast for at least five days at a clinic. Researchers track changes in weight, blood sugar, and well-being during the fast and for three months after, using questionnaires, continuous glucose monitors, and…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …