Post-COVID-19 disorder

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This study tested whether a combination of L-citrulline supplements, nutritional therapy, and pulmonary rehabilitation could help recovered COVID-19 patients improve their blood vessel health, body composition, and physical function. 43 adults aged 40-80 who had recovered from CO…

This study tested whether the antiviral drug Paxlovid can help people with Long COVID by clearing leftover virus or calming an overactive immune system. Nearly 1,000 adults took either Paxlovid or a placebo for different lengths of time. Researchers tracked improvements in thinki…

This study tested whether a steroid (beclomethasone) placed directly in the nose using a tiny sponge could help people who lost their sense of smell after COVID-19. Sixteen adults with smell loss lasting over 3 months received either the steroid or a placebo sponge twice, two wee…

This study tested different treatments for autonomic dysfunction, including POTS, in 381 adults with Long COVID. It compared non-drug approaches and medications to see which best eased symptoms like rapid heart rate and dizziness. The goal was to find effective ways to manage the…

This study tested whether a procedure called immunoadsorption — which filters certain antibodies out of the blood — can reduce fatigue in people with chronic fatigue syndrome (ME/CFS), including those whose condition started after COVID-19. Sixty-six adults received either five r…

This study tested the antiviral drug Paxlovid in 963 adults with Long COVID. The goal was to see if clearing leftover virus or calming the immune system could ease symptoms. Participants received either a 25-day or 15-day course of Paxlovid or a placebo. The trial is complete, bu…

This study looked at 73 children with MIS-C, a rare inflammatory condition linked to COVID-19. Researchers compared three treatments—infliximab, anakinra, and steroids—to see which helped kids recover fastest without needing more therapy. The goal was to find the safest and most …

This study tests whether ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18–65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track changes in symptoms, brain scans, and inf…

This completed trial tested whether fluvoxamine, an FDA-approved drug for OCD, can improve long COVID symptoms like trouble concentrating, anxiety, depression, and fatigue. 191 adults from Missouri and Illinois who had COVID at least 3 months earlier took either fluvoxamine or a …

This study tested a 20-session physical rehabilitation program for 74 adults with long COVID. The program included treadmill walking and stretching, with intensity increasing over time. Researchers measured handgrip strength and walking ability before and after the program to see…

This study tested different treatments to help with sleep problems caused by Long COVID. It involved 361 adults and looked at improving daytime sleepiness and overall sleep quality. The goal was to find which treatments work best for these specific sleep issues.

This study tested two simple treatments—melatonin pills and tailored light therapy—to help people with Long COVID who have trouble sleeping. About 470 participants were randomly assigned to receive either melatonin, a placebo, or light therapy. The goal was to see if these treatm…

This pilot study tested a Spanish-language chronic-disease self-management program called 'Tomando control de su salud' in 47 adults with Long-COVID and at least one other chronic condition in Puerto Rico. The goal was to see if the program could improve quality of life, reduce f…

This completed study looked at whether a once-a-week home-based resistance exercise program could help reduce fatigue in veterans aged 50 and older with Long COVID. The study enrolled 21 participants and measured changes in muscle strength and perceived tiredness. The goal was to…

This study tested whether a low-sugar diet, eating only during a 8-12 hour window each day, and periodic water fasts could reduce Long COVID symptoms. 77 adults with at least five Long COVID symptoms participated. The goal was to see if these dietary changes could lower symptom s…

This study tested whether acupuncture can reduce pain and improve daily life for people with long COVID. 93 adults with persistent pain after COVID-19 were randomly assigned to receive 8 acupuncture sessions or continue their usual care. Researchers measured pain intensity and it…

This study tested a therapy called Cognitive Muscular Therapy (CMT) for people with Long-COVID who have trouble breathing. CMT combines breathing retraining with techniques to reduce overactive muscles that can interfere with breathing. 18 adults with moderate to severe breathles…

This study tested whether a simple home program of breathing exercises and walking at least 6000 steps daily could ease long COVID symptoms like cough, breathlessness, and fatigue. Forty adults with long COVID followed the program for six weeks. Researchers tracked changes in sym…

This study tested a structured pacing program for 300 people with Long COVID who experience exercise intolerance and post-exertional malaise. Participants worked with a pacing coach for 12 weeks to manage their activity and symptoms. The goal was to see if pacing could improve ex…

This study tested whether a gentle, noninvasive microcurrent treatment can reduce muscle pain in people who had COVID-19. Forty adults with post-COVID musculoskeletal pain were randomly assigned to receive either real or sham microcurrent therapy for 12 sessions. Researchers meas…

This completed study tested a digital rehab program combining cognitive training, physical exercise, and mindfulness for people with long COVID who have memory and thinking problems. 172 adults with persistent cognitive symptoms at least 12 weeks after COVID-19 took part. The pro…

This study tested Pycnogenol, a natural pine bark extract, against a placebo in 153 adults with Long COVID. The goal was to see if it improves overall health and reduces symptoms like fatigue and brain fog. Participants took the supplement for 12 weeks and reported their health s…

This study tested whether a 12-week exercise program done at home via video calls could help people with long COVID feel better. 120 adults aged 20-80 with long COVID took part. The program aimed to reduce symptoms like fatigue and brain fog, and improve fitness and quality of li…

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This completed Phase 3 trial tested whether two widely available drugs—fluvoxamine (an antidepressant) and metformin (a diabetes drug)—can reduce fatigue and other symptoms in people with long COVID. 399 adults with confirmed prior COVID-19 infection and persistent symptoms took …

This study tested two breathing devices—a Lung Boost trainer and an incentive spirometer—to see which better improves lung function in 60 children aged 4-9 with cerebral palsy who had recovered from COVID-19. All children also received standard breathing therapy. The goal was to …

This study tested a virtual attention training program for 58 adults with Long-Covid brain fog. The goal was to see if the program is feasible and improves focus and thinking. Participants completed sessions online, and researchers measured attention changes before and after trai…

This study tested whether a non-invasive treatment called enhanced external counterpulsation (EECP) can improve heart and lung function in adults with long COVID. Ten participants received EECP therapy on one of two schedules. Researchers measured exercise capacity, symptoms, and…

This study tested whether low-dose naltrexone (LDN) can reduce fatigue and improve related symptoms in people with post-COVID fatigue syndrome. 160 adults who had confirmed COVID-19 and met criteria for post-COVID fatigue took either LDN or a placebo for 16 weeks. The main goal w…

This small study tested whether sitting under a bright light for 30 minutes a day for two weeks could help people with long-lasting fatigue after COVID-19. Twelve adults who had been tired for months after their infection took part. The goal was to see if the light therapy could …

This study tested whether a remote cognitive strategy training program (CO-OP) is feasible for people with Post-COVID syndrome who have memory or thinking problems. 65 participants learned a step-by-step problem-solving method (Goal-Plan-Do-Check) to improve daily activities. The…

This study tested whether a 6-week personalized day-hospital program could improve quality of life for 80 people with persistent long COVID symptoms like fatigue, shortness of breath, and brain fog. The program included group education, tailored exercise, and cognitive behavioral…

This completed Phase 2 study tested whether the oral drug Xiflam (tonabersat) can safely reduce symptoms of Long COVID compared to a placebo. Sixteen adults who had COVID-19 and then developed lasting symptoms for at least 12 weeks took part. Participants received either Xiflam o…

This Canadian trial tested two drugs, ibudilast and pentoxifylline, against a placebo in 460 adults with lingering COVID-19 symptoms. Participants took the drugs for 2 months and were followed for 4 more months to see if symptoms improved. The goal is to find safe, effective trea…

This study looked at whether eating 2 ounces of walnuts every day for 12 weeks could improve memory and reduce brain fog in adults over 40 with Long-COVID. About 31 people took part, comparing walnut eaters to those getting usual care. The goal was to see if walnuts, which are ri…

This completed Phase 2 trial tested whether ivabradine, a drug that slows heart rate, can reduce symptoms like dizziness and rapid heartbeat in people with long COVID. 181 participants received either ivabradine or a placebo for 3 months, with follow-up for another 3 months. The …

This study tested whether the antiviral drug remdesivir could help people with Long COVID. 73 adults with confirmed Long COVID received five daily doses of the drug through an IV. Researchers measured how many people completed the treatment and tests, and how well they tolerated …

This small study tested whether a 7-day fast is a safe and acceptable option for adults with Long COVID. 25 participants fasted at home and had checkups before and after. The goal was to see if fasting could improve daily function and quality of life by reducing inflammation. Res…

This study looked at whether a breathing exercise using pressure biofeedback can help women with long COVID-19 improve their breathing muscle strength. 80 women who had COVID-19 and still had breathing problems took part. They did special diaphragm training for four weeks. The go…

This study tested whether a low-level magnetic therapy device, used at home, is safe and practical for people with Long COVID who have memory and thinking problems. Thirty adults with persistent cognitive issues after COVID-19 used the device daily for 4 weeks, then were followed…

This study tested a device called the Human Regenerator Jet, which emits cold atmospheric plasma, to see if it can improve quality of life in adults with chronic stress, fatigue, pain, or Long COVID. Forty participants received 10 sessions of either the plasma or plain air, and r…

This study tested whether amantadine, a medication used for other conditions, can improve memory and thinking problems in people with Long COVID. 64 adults with lasting cognitive issues after a COVID infection took part. Researchers also looked for lab markers that might predict …

This study tested a rehabilitation program to help adults with Post-COVID-19 syndrome who suffer from ongoing fatigue. 54 participants completed the program, which aimed to reduce tiredness and improve daily life. The study measured fatigue using several scales to see if the reha…

This study tested a 6-week outpatient rehab program for 125 adults with Long COVID. The program included physical and speech therapy tailored to each person's needs, aiming to improve breathing, thinking, and daily function. Researchers measured progress using a six-minute walk t…

This study tested different treatments for sleep problems caused by Long COVID. It included 830 adults who had COVID-19 and now have trouble sleeping or feel very sleepy during the day. The goal was to see if treatments matched to specific sleep issues could help people feel bett…

This study tested a 9-week program combining group education and physical rehabilitation for people with Long COVID. 74 adults participated to see if the program could improve quality of life, mental well-being, and physical condition while reducing anxiety, depression, and fatig…

This study tested whether qigong, a gentle practice of slow movements and meditation, could improve quality of life for people with Long COVID. Forty adults with symptoms lasting over 12 weeks attended six weekly group sessions. Researchers measured changes in physical and mental…

This study tested whether diaphragmatic breathing exercises can help people with Long COVID who have trouble breathing and feel tired. Sixteen adults who had COVID-19 at least four weeks earlier and still had symptoms like shortness of breath and fatigue took part. The goal was t…

This completed pilot study tested a daily ultrasound device applied to the spleen for 8 weeks in 15 adults with Long COVID. The goal was to see if it safely improves symptoms like fatigue, pain, and brain fog. Researchers measured walking endurance and fatigue levels before and a…

This study tested two wellness products that stimulate the vagus nerve—a key nerve for stress, mood, and inflammation—to see if they could help people with Long COVID. Over 500 participants used the devices and tracked their health with a Fitbit and surveys. The goal was to measu…

This study tested an oral drug called LAU-7b (fenretinide) in 272 adults with moderate to severe Long COVID symptoms lasting at least 12 weeks. Participants took the drug or a placebo in cycles of 14 days on, 14 days off, for 12 weeks. The main goal was to see if LAU-7b improves …

This study tested a 12-week smartphone program called SuperCAP for people with post-COVID syndrome. The program includes daily games, exercises, and videos to improve thinking, mood, and daily function. Sixty adults with ongoing cognitive complaints took part, and researchers mea…

This completed study tested a dietary supplement containing quercetin and curcumin in 15 adults with mild to moderate Long COVID symptoms like fatigue, brain fog, and body pain. Participants took two capsules twice daily for 8 weeks. The goal was to see if the supplement could re…

This study tested a 10-week group program that teaches self-help strategies from European, Chinese, and Indian traditional medicine for people with post-COVID syndrome. 86 adults with persistent symptoms after COVID-19 took part. The goal was to see if these techniques, added to …

This study tested different treatments to help people with Long COVID who struggle with exercise and feel very tired after activity. Researchers enrolled 660 adults across multiple medical centers to see if these treatments could improve exercise ability, daily activity, and qual…

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This study tested an 8-week tele-rehabilitative exercise program for nurses with long COVID. The program included aerobic and strengthening exercises done at home using a wearable knee brace and a smartphone app. Researchers measured changes in fatigue, heart and lung fitness, lo…

This study tested whether infusions of donor stem cells (HB-adMSCs) could reduce long COVID symptoms like extreme fatigue, brain fog, and headache. About 79 adults with chronic post-COVID syndrome received four IV doses of stem cells or a placebo over 10 weeks. Researchers tracke…

This study tested whether a daily whey protein supplement called Immunocal could help with memory and attention problems after COVID-19. 120 adults with mild to moderate cognitive issues were split into three groups: Immunocal, cognitive rehab workshops, or no treatment. After 12…

This study tested a special type of radiofrequency (448 kHz) combined with manual techniques to help people with ongoing breathing issues after COVID-19. 96 adults who had COVID and still had cough, shortness of breath, or fatigue for over a month received the treatment. The goal…

This study tested a program called AIR + Mindfulness, which aims to retrain parts of the brain (amygdala and insula) to reduce long COVID symptoms like fatigue, pain, and brain fog. 120 adults with persistent COVID took part in either the brain retraining program or a relaxation …

This study tested a blood filtering procedure called immunoadsorption to see if it reduces fatigue in people with post-COVID syndrome. 63 patients received either the real procedure or a sham version over 14 days. The goal was to measure changes in fatigue and other symptoms like…

This study tested whether a daily breathing exercise program can help people with long COVID who have weak respiratory muscles. 44 adults with long COVID and reduced inspiratory muscle strength were randomly assigned to either breathing exercises plus physical exercise, or physic…

This study tested whether motion-controlled video games in virtual reality could help people with long COVID feel better. 79 participants either played VR games or did standard exercises. Researchers measured pain, fatigue, mood, and quality of life to see if the VR approach was …

This study tested whether taking Paxlovid for 15 days can reduce severe Long COVID symptoms like fatigue, brain fog, and shortness of breath. 168 adults with persistent symptoms after COVID-19 took either the drug or a placebo. Researchers tracked symptom severity over 15 weeks t…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This study looks at anonymous health records from California and Louisiana to see if the Pfizer-BioNTech COVID-19 vaccine helps prevent post-COVID conditions (long COVID). Researchers will also track who gets vaccinated. The study includes adults with a COVID-19 diagnosis between…

This completed study used advanced MRI and CT scans to look for lasting damage in the brain, heart, lungs, and liver of 206 people who had COVID-19. Researchers compared those who were hospitalized with those who were not, to understand how the virus affects organs over time. The…

This completed pilot study scanned the brains of 30 people who were hospitalized with COVID-19 and later reported memory, concentration, or organizational problems—often called 'brain fog.' Researchers used MRI and spectroscopy to look for changes in brain structure and chemistry…

This study tracked 204 patients with blood cancers or those on certain immune-suppressing treatments to see how often COVID-19 infection persists for 21 days or more. Researchers also looked for factors that make a long infection more likely. The goal was to better understand who…

This study looked at how many people in Punta Arenas, Chile, have persistent COVID-19 (long COVID) — symptoms lasting more than 4 weeks after infection. Researchers surveyed and tested 282 adults who had COVID-19, checking their physical and mental health, and looking for risk fa…

This study tested whether a special PET scan tracer is safe for people with Long COVID. Six adults with a history of COVID-19 (some with ongoing symptoms, some without) received the tracer and MRI scans. The goal was to see if the tracer can highlight brain inflammation differenc…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study watched 60 adults with ME/CFS (a condition causing severe fatigue) after they received hyperbaric oxygen therapy (HBOT) in a high-pressure chamber. Participants filled out health questionnaires to track changes in physical function and fatigue. The goal was not to prov…

This study tested a program for people with long-COVID that includes an online screening, a detailed in-person assessment, and digital training modules with a personal counselor. 192 participants from Bavaria took part to see if this approach is practical and helpful. The goal wa…

This study interviewed 25 adults with long COVID to understand how the condition affects their daily life, work, and experience with healthcare. Researchers aimed to learn about the challenges patients face and what helps or hinders their return to work. The study does not test a…

This study reviewed medical records of 200 adults from an endocrinology clinic to see if taking vitamin D3 supplements lowered their chances of developing Long COVID after a COVID-19 infection or getting COVID-19 after vaccination. Researchers compared patients who took vitamin D…

This completed study followed 530 working-age adults (18–70) who were hospitalized for COVID-19. Researchers measured disability using WHO checklists at 12 and 36 months after hospitalization. The goal was to understand how severe COVID-19 affects people's ability to function and…

This completed study took blood samples from 62 people with Long COVID and compared them to healthy controls. Researchers looked for specific immune and metabolic patterns that might explain why symptoms persist. The goal is to better understand Long COVID, not to test a treatmen…

This study followed 171 people with Long COVID who had brain fog and other thinking problems. Researchers looked at what treatments patients received and how their quality of life changed over 6 months. The goal was to see if certain treatments helped improve daily functioning. B…

This study examined 69 adults with Long-COVID to see how different levels of fatigue relate to their thinking, mood, and physical abilities. Participants completed tests of hand strength, walking distance, memory, and anxiety. The goal was to identify patient subgroups to better …

This completed study looked at 355 adults with Long COVID in Suffolk and North Essex to understand their symptoms and rehabilitation needs up to 36 months after infection. The goal was to better diagnose and manage the condition, focusing on helping people return to everyday acti…

This study looked at 51 adults who had COVID-19 2 to 12 months earlier and still had brain fog or other thinking problems. Researchers checked if the virus was still hiding in the nose's smell center. They compared these patients to a control group to see if lingering virus is li…

This large observational study followed over 15,000 adults in the U.S. to learn more about long COVID (Post-Acute Sequelae of SARS-CoV-2 infection). Researchers tracked symptoms, health history, and biological samples over time in both infected and uninfected people. The goal is …

This study looked at 13 adults who had COVID-19 and still had symptoms like memory or nerve problems after recovery. Researchers used brain scans, memory tests, smell tests, and other exams to find possible changes in the nervous system. The goal was to better understand how COVI…

This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers …

This study followed over 4,200 Dutch COVID-19 patients for up to two years to learn about long COVID symptoms like exhaustion, breathing problems, and mental health issues. Researchers also looked at how these symptoms affect quality of life and what factors might predict who get…

This completed study used a special imaging method called electrical impedance tomography (EIT) to look at lung function in 100 people with long COVID who have trouble breathing, compared to 50 healthy volunteers. The goal was to see if EIT can detect changes in how air moves thr…

This study looked at whether chronic stress before catching COVID-19 makes long COVID more likely. Researchers followed 380 adults who tested positive for SARS-CoV-2 and had symptoms. They measured stress levels and tracked whether symptoms lasted beyond four weeks. The goal is t…