Can retraining your brain ease long COVID?

NCT ID NCT05956405

Completed Symptom relief Sponsor: Hospital Miguel Servet Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a program called AIR + Mindfulness, which aims to retrain parts of the brain (amygdala and insula) to reduce long COVID symptoms like fatigue, pain, and brain fog. 120 adults with persistent COVID took part in either the brain retraining program or a relaxation program over two months. The goal was to see if this approach could improve their quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AIR + Mindfulness program (behavioral intervention)
What this could lead to: If it works, this could offer a non-drug way to ease long COVID symptoms like fatigue, brain fog, and mood issues.
What could go wrong: This is a small, completed trial without a placebo control, so results may not be widely applicable. The intervention is behavioral, not a cure, and benefits may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENTAL HEALTH WELLNESS

Contacts and locations

Locations

Department of Psychiatry. Miguel Servet University Hospital

Zaragoza, 50009, Spain

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