Low-Dose naltrexone tested for long COVID fatigue
NCT ID NCT05430152
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether low-dose naltrexone (LDN) can reduce fatigue and improve related symptoms in people with post-COVID fatigue syndrome. 160 adults who had confirmed COVID-19 and met criteria for post-COVID fatigue took either LDN or a placebo for 16 weeks. The main goal was to see if LDN significantly lowered fatigue levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
low-dose naltrexone (LDN)
What this could lead to
If it works, this could offer a new treatment option for people suffering from long-lasting fatigue after COVID-19.
What could go wrong
This is a Phase 2 trial, so results are still early. The drug may not prove effective for everyone, and side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Women's Health Research Institute
Vancouver, British Columbia, V6H 3N1, Canada