Cognitive disorder

Researchers are testing a new enzyme replacement therapy called GNR-055 in people with Hunter syndrome (MPS II), a rare inherited disorder that causes harmful sugar molecules to build up in the body. The trial enrolls about 32 patients, including those who have never had enzyme t…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and other brain functions in adults aged 65 to 80. It also checks for changes in blood pressure and overall life satisfaction. About 97 participants who are already in…

This study looks at whether a combination of ibogaine-magnesium, 5-MeO-DMT, magnetic e-Resonance therapy (MeRT), and physiological supplements can help special operations veterans with PTSD, depression, suicidal thoughts, and cognitive problems from traumatic brain injury. Partic…

This phase 3 study tests whether donanemab, an antibody given through an IV, can safely slow cognitive decline in 1500 people with early Alzheimer's. Participants receive either the drug or a placebo for up to 93 weeks. The main goal is to measure changes in thinking and daily fu…

This study tests whether combining virtual reality cognitive training with physical activity can improve memory and brain health in adults aged 50 to 85. Participants are randomly assigned to 16 weeks of physical activity, VR cognitive activity, or both. The main goal is to see i…

This study investigates whether SGLT2 inhibitors, a class of diabetes medications, can slow cognitive decline in people aged 50 and older with type 2 diabetes. Participants are randomly assigned to receive either standard diabetes care plus an SGLT2 inhibitor (empagliflozin or da…

This study tests different dosing schedules of the drug donanemab in about 1,175 people with early symptomatic Alzheimer's disease. The goal is to find a regimen that lowers brain amyloid plaques while reducing the risk of a side effect called ARIA-E (brain swelling or small blee…

This early-stage study tests a gene therapy called AB-1001 in 5 adults with early Huntington's disease. The treatment is injected directly into the brain to potentially slow the disease. The main goal is to check safety, but researchers will also look at brain changes on MRI and …

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or sicker patients and may be caused by inflammation harming the brain. The trial includes 82…

This study tests whether a computerized brain-training program can improve thinking skills in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either adaptive cognitive training or a placebo version, both…

This study tests whether smartphone usage data can help tell the difference between normal memory complaints, mild cognitive decline, and Alzheimer's disease. Researchers will collect data from 90 participants' phones over three months. If it works, it could offer a simple, low-c…

This study tests a plant-based supplement called PhytoSERM in 100 women aged 45-60 who are in or just past menopause. The goal is to see if it can prevent changes in brain activity and thinking skills that often happen during this time. Participants take either the supplement or …

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This study tests whether daily listening to Mozart's Sonata for two pianos in D major (K448) can reduce seizures and improve thinking skills in children with drug-resistant epilepsy. Researchers will compare a group that listens to K448 for 8 minutes each day for 2 months with a …

This study compares two exercise programs for adults aged 65 and older living in residential care. One group does short, frequent 'exercise snacks' twice a day, while the other does longer, structured sessions a few times a week. Over 12 weeks, researchers will measure changes in…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study is testing the long-term safety of a drug called ML007C-MA for people with Alzheimer's disease who also have hallucinations and delusions. About 210 adults who completed a previous study will take the drug twice daily for up to 52 weeks. The goal is to see if the drug …

This study tests whether computer-based brain-training games can improve memory, focus, and thinking in breast cancer survivors who report cognitive problems (often called 'chemo brain'). About 386 survivors will be randomly assigned to play either specially designed neuroplastic…

This study compares two drugs, pramipexole and escitalopram, to treat major depression in people with HIV. Some participants also have mild memory or thinking problems. The goal is to see which medication is safer and more effective at easing depression symptoms. About 186 adults…

This study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …

This study compares how honey versus table sugar, each paired with almonds, affects blood sugar levels, hunger, and fullness in 58 healthy premenopausal women. Participants will eat snacks containing honey or sugar with or without almonds, and their glucose will be tracked with a…

This pilot study is testing a type of talk therapy called Metacognitive Interpersonal Therapy (MIT-ED) for adults with various eating disorders, including those who are underweight. The therapy aims to help people understand and manage the negative thoughts and feelings that driv…

This pilot study is testing whether taking 24 grams of whey protein daily for three months can improve brain antioxidant levels, physical function, and thinking skills in pre-frail adults aged 65 to 85. Twenty participants will be randomly assigned to receive either whey protein …

This study tests whether a 20-week program of exercise alone or exercise combined with cognitive training can improve thinking and memory in breast cancer survivors. 108 women who have finished primary treatment will be assigned to one of three groups: dual-task training, exercis…

This study tests whether inhaling rosemary essential oil can improve memory, attention, and other thinking skills in healthy adults. 63 participants will either sniff rosemary oil or a placebo for 14 days and take brain tests before and after. The goal is to see if this natural r…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve memory, attention, and thinking in older adults who have noticed their thinking is slipping. Twenty participants will receive either real or sham stimulation over several weeks. Researcher…

This study compares two approaches to help stroke survivors with mild to moderate thinking problems. Both groups use a web-based computer game that trains how quickly they process information. One group also gets in-lab training on everyday activities, while the other focuses on …

This pilot study tests whether a telehealth program called HOBSCOTCH-PACS can help people with long COVID manage memory and thinking problems. Ten participants will attend nine virtual coaching sessions and complete questionnaires about their quality of life and cognitive functio…

This study tests whether a mild electrical current applied to the scalp (tDCS) before computer-based cognitive training can improve thinking skills like memory and attention in people with schizophrenia. 120 adults aged 18-65 will receive either real or fake tDCS for 20 minutes, …

This study tests whether partnered dance aerobic exercise can reduce 'OFF-time' (when Parkinson's medication stops working well) and improve thinking skills. Researchers will enroll 82 people with Parkinson's who experience OFF-time. Participants will take dance classes twice a w…

This study tests a 12-session personalized program for adults 65 and older who have fallen at least once in the past year. The program focuses on balance, safe walking, home adjustments, and activities that matter to each person. Researchers will measure improvements in balance, …

This study tests a therapy called imagery rescripting in 8 people with early psychosis. Participants imagine a different, more positive outcome to their traumatic memories. The goal is to see if this improves core beliefs, wellbeing, and self-esteem. It is a very small, early-pha…

This study tests whether a gentle electrical brain stimulation technique called tDCS, combined with cognitive training on a tablet, can reduce apathy in older adults with mild cognitive impairment. Apathy is a lack of motivation and interest that can affect daily life. The trial …

This early-phase study tests whether a noninvasive technique called transcranial focused ultrasound (tFUS) can improve memory in people with mild neurocognitive disorder and in healthy older adults. Using MRI guidance, the device sends sound waves to specific brain areas. The tri…

This pilot study tests a home-based program called HOBSCOTCH, designed to help people with multiple sclerosis manage memory and thinking problems. Eleven participants will attend virtual coaching sessions and complete questionnaires about their quality of life and cognitive funct…

This study tests a special exercise program for older Veterans with dementia living in VA nursing homes. The program, called PLIÉ, combines gentle movement and mental focus to improve physical function, mood, and social engagement. Staff will be trained to lead the classes, and r…

This study tests whether teaching memory strategies and promoting exercise, mental activities, and stress management can help older adults with memory concerns keep their thinking sharp. About 263 people aged 65 and older with normal cognition but subjective memory worries will j…

This study looks at whether osteopathic manipulation, a type of hands-on treatment, can help adults aged 40 and older who have both pain and thinking problems like trouble with memory or focus. The researchers will measure changes in pain, thinking skills, and stress-related mark…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study follows 110 people with brain metastases who are receiving either focused or whole-brain radiation. Researchers use advanced MRI scans and memory tests before treatment and for two years after to see if the scans can predict thinking and memory problems. The goal is to…

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

Researchers at the University of Cincinnati are studying how brief electrical brain stimulation affects the brain waves that help us stay focused and switch between tasks. They will record brain activity from over 100 electrodes in adults with epilepsy who are already undergoing …

This study looks at whether a digital version of the classic clock-drawing test can help identify older adults at higher risk for confusion or memory issues after surgery. Researchers will analyze data from thousands of patients aged 65 and older who take the test before an opera…

This study follows 1,000 adults aged 50 and older to see how the health of their heart and blood vessels relates to early signs of Alzheimer's disease and brain aging. Researchers will use brain scans, memory tests, and blood or spinal fluid samples to look for connections betwee…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study tests whether pairing vagus nerve stimulation (VNS) with language training can improve memory and learning in people who have already used VNS for movement recovery after a stroke. Participants, who already have a VNS implant, will try learning a new language while the…

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study investigates factors that may influence cognitive skills—like memory, attention, and problem-solving—in women diagnosed with fibromyalgia. Researchers will assess thinking abilities using a detailed cognitive test and measure how fibromyalgia affects daily life. The go…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study looks at how thinking, memory, and movement change in older adults with conditions like dementia or Parkinson's disease. Researchers will use tests, brain scans, and lab samples to find clues for earlier diagnosis and better care. About 260 people, including healthy vo…

This study looks at whether restoring chewing ability through dental procedures can improve memory and thinking in adults aged 65-80. Eighty participants with chewing problems will be randomly assigned to receive dental rehabilitation either immediately or after a waiting period.…

This study looks at whether a web-based education program can boost brain health knowledge in older adults (60+) before elective non-cardiac surgery. Researchers will measure changes in knowledge scores after patients complete the online module. The goal is to help patients and f…

This study uses brain imaging techniques like MRI and EEG to explore how brain lesions cause cognitive deficits such as reading or visual perception problems. Researchers will study 1,500 patients and healthy volunteers using a detailed single-case approach. The goal is to better…

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…

Researchers at Stanford are creating a database to better understand why some older adults experience memory or thinking problems after surgery with anesthesia. They will collect information from 250 patients aged 65 and older, including blood samples, brain wave recordings, and …

This study aims to translate and test a cognitive assessment tool called the ECCA (Electroconvulsive Therapy Cognitive Assessment) into Turkish. The ECCA is designed to measure memory, attention, and other thinking skills that can be affected by electroconvulsive therapy (ECT), a…

This study follows over 6,600 elderly patients (aged 60+) who had major surgery to see if lighter anesthesia helps them live longer. The original trial found no difference in survival at one year, but this follow-up checks for effects beyond that, including on cancer recurrence a…

This study translates a scale that measures how thinking difficulties affect daily life in people with Parkinson's disease into Turkish. Researchers will test the translated version in 60 Turkish-speaking Parkinson's patients to see if it is valid and reliable. The goal is to giv…

This study looks at whether it's possible to track memory and thinking changes in adults aged 65 and older who are starting a new type of cancer treatment called immune checkpoint inhibitors. Thirty participants will take simple memory and concentration tests every six weeks for …

This study looks at how focused ultrasound (sound waves) aimed at the cerebellum changes brain activity and thinking in 20 healthy adults aged 18 to 40. Participants do thinking tasks after real or fake ultrasound. The goal is to learn how the cerebellum affects brain function, n…

This study follows 826 ICU survivors to understand why some develop long-term thinking and memory problems. Researchers will look at factors like delirium and sedative use during the ICU stay. The goal is to find modifiable risks that could lead to better prevention and recovery …

This study looks at whether a supplement made from black rice extract can increase levels of BDNF, a protein important for memory and mood. Researchers will give 12 healthy adults either the supplement or a placebo and measure BDNF in their blood. The goal is to see if this natur…

This study examines whether self-awareness—knowing your own strengths and limits—can predict fall risk in older adults and rehab patients. About 100 participants aged 60-85 will complete cognitive tests, questionnaires, and walking assessments with wearable sensors. The goal is t…

This study measures brain activity and chemical levels in people with epilepsy who already have electrodes implanted for medical reasons. Participants play simple computer games while their brain signals are recorded. The goal is to learn how the brain works during thinking and e…

This study looks at how cancer treatment and multiple rounds of anesthesia affect thinking skills, emotions, and quality of life in people who survived retinoblastoma (a rare eye cancer) or were at risk for it. Researchers will test memory, attention, and other brain functions in…

This study follows 1,800 adults with reduced kidney function (not on dialysis) to see how nutrition and lifestyle affect their health. Researchers will track changes in kidney function, heart health, bone health, and thinking skills over time. The goal is to find better ways to m…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study uses blood samples and health data from over 13,000 older adults to see if Alzheimer's-related blood markers differ between men and women. Researchers aim to create a sex-specific risk score that could help predict the disease earlier and personalize future treatments.…

This study looks at whether people with atrial fibrillation (AF) have temporary drops in thinking skills during an AF episode. Researchers will test 600 patients using tablet-based games that measure memory, attention, and decision-making while in AF and again after their heart r…

This study follows 120 people in group therapy for alcohol use disorder to see which patient factors—like mental health, drinking severity, personality, or thinking skills—predict who finishes treatment and stays sober a year later. Researchers hope to learn how to match patients…

This study was designed to test whether eating blueberries or taking blueberry powder every day for 12 weeks could improve memory and thinking in older adults with mild memory complaints. It planned to include people aged 65 and older who were overweight and had some memory conce…

This study looks at why depression often comes back in older adults and how it affects memory and thinking. Researchers will follow 210 people aged 60 and older, some currently depressed and some in remission, using brain scans and daily mood tracking. The goal is to find biologi…

This study follows 505 adults aged 50 and older who are having hip or knee replacement surgery. Researchers use a simple online card-game test to measure changes in memory, attention, and thinking before and up to 4.5 months after surgery. The goal is to find out how many people …