Aortic valve disorder

This trial tests whether empagliflozin, a drug already used for diabetes and heart failure, can prevent the heart muscle from thickening or developing fibrosis in people with moderate aortic stenosis. Participants will receive either empagliflozin or standard care for six months,…

This study tested whether implanting a new aortic valve (TAVI) without first using a balloon to open the narrowed valve is safer and as effective as the standard procedure with balloon predilatation. 250 adults with severe aortic stenosis who were at high risk for open-heart surg…

This study tested a device called ShortCut that splits the leaflets of a failing artificial heart valve before placing a new valve inside it. The goal was to prevent the old leaflets from blocking the coronary arteries, which can cause a heart attack. Eight people at risk for thi…

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested a device designed to catch and remove debris that can break loose during transcatheter aortic valve replacement (TAVR), a procedure to replace a narrowed heart valve. The device uses two filters placed in arteries leading to the brain. The trial involved 260 peo…

This study followed 650 low-risk patients with severe aortic valve narrowing who received a less invasive valve replacement called TAVI. Researchers tracked deaths, strokes, and return hospital visits for heart problems. The goal was to see how well TAVI works in everyday practic…

This study tested whether empagliflozin (Jardiance), a diabetes drug, can help the heart recover after aortic valve replacement. 206 patients took either the drug or a placebo for six months. The goal was to see if the drug reduces heart muscle thickness and improves symptoms.

This study looked at whether giving a drug called protamine to all patients after a minimally invasive heart valve replacement (TAVI) reduces bleeding complications compared to giving it only when needed. The trial involved 1000 adults with aortic valve stenosis. The goal was to …

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…

This study tested a new way to replace a narrowed heart valve without open-heart surgery. It involved 782 people with severe aortic stenosis who were considered too high-risk for traditional surgery. The procedure, called TAVI, uses a thin tube to place a new valve inside the hea…

This pilot study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve. 24 adults with mild-to-moderate aortic stenosis were randomly assigned to take colchicine or a placebo for 6 months. The study measured changes in valve cal…

This study compared two different artificial heart valves (Sapien and Myval) used in a procedure called TAVI to replace a narrowed aortic valve. Over 1,000 patients were randomly assigned to receive one of the two valves. The goal was to see which valve led to fewer major heart p…

This study tested two new heart valves (Portico and Navitor) in 30 Indian patients with severe aortic stenosis, a condition where the heart's main valve narrows. The goal was to see if the valves are safe and work well. Researchers tracked complications and heart function for up …

This study tested a new device called the ALLEGRA THV System with a new delivery system (IMPERIA) in 137 people with severe calcified aortic stenosis or a failed surgical valve. The main goal was to see if the valve worked well and was safe 7 days after the procedure. The study c…

This study tested whether the anesthetic sevoflurane protects the heart better than propofol during aortic valve replacement surgery. 82 patients were randomly assigned to receive either sevoflurane or propofol during and after surgery. The researchers measured troponin levels, a…

This study tested a new tool called TELLTALE designed to safely cut a heart tissue flap during a valve replacement procedure (TAVR). In some cases, this flap can block blood flow to the heart, which is often fatal. The trial involved 90 adults at high risk of this complication. R…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested an optimized care plan for people with a narrowed aortic heart valve who received a new valve through a catheter (TAVR). Over 1,100 patients were enrolled to see if the improved care pathway could lower risks like death, stroke, and the need for a pacemaker. The…

This study tested a new device, ProtEmbo, designed to catch debris and protect the brain during a heart valve replacement procedure called TAVR. 284 people with severe aortic stenosis took part. The goal was to see if the device reduces brain injury and major complications compar…

This study tested a balloon catheter called Alwide Plus, used to widen the aortic valve before replacing it in people with severe aortic stenosis. 75 patients took part across multiple hospitals in China. The results showed the balloon was safe and effective for this pre-dilation…

This study tested a special heart-protection method given during heart surgery to see if it could reduce damage to the heart muscle. 210 adults having aortic valve surgery took part. Researchers measured a protein called troponin I in the blood for 72 hours after surgery to check…

This study tested a procedure called left atrial appendage occlusion (LAAO) against standard blood-thinning medications in 81 people with atrial fibrillation who were also getting a new heart valve (TAVI). The goal was to see if LAAO could prevent strokes and bleeding better than…

This study looked at how safe and effective Abbott's Regent mechanical heart valve is for Chinese patients needing a new aortic valve. Researchers followed 200 adults who received the valve to track valve-related deaths and the need for repeat surgery. The goal was to confirm the…

This study looked at two surgical options for replacing a worn-out aortic heart valve in people aged 60-74. Researchers compared a standard stented biological valve with a donated human valve (allograft) to see which led to better survival and fewer complications. The goal was to…

This study tested a new heart valve, the SAPIEN 3, in 58 Chinese patients with severe aortic stenosis who were at high risk for traditional open-heart surgery. The valve was implanted using a thin tube through a blood vessel, avoiding the need for open surgery. The main goal was …

This study tested a new heart valve called Evolut PRO in 638 people with severe aortic stenosis who were at high risk for open-heart surgery. The valve was implanted using a thin tube through an artery, avoiding major surgery. Results showed that only 3.3% of patients died within…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This study tested whether a computerized stethoscope that uses artificial intelligence (AI) can accurately detect two common heart valve conditions: aortic stenosis and mitral regurgitation. Researchers at Mayo Clinic recorded heart sounds from 400 adults and compared the AI's an…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested whether making a small cut in the sac around the heart (posterior pericardiotomy) during open-heart surgery can prevent a common complication called atrial fibrillation. 210 adults having elective heart surgery in Yemen were randomly assigned to receive either t…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study tested a new device called VIVHEART EasyCross™ in 20 people undergoing transcatheter aortic valve replacement (TAVR). The device uses a basket-like tip to center itself in the artery, making it easier and quicker to guide a wire through the heart valve. The goal was to…

This study looked at whether a single intravenous iron dose could improve exercise capacity in people with severe aortic stenosis and iron deficiency who were scheduled for a valve replacement. About 100 participants received either iron or a placebo. The main goal was to see if …

This study looked at whether motivational coaching and a home exercise program can help older adults become more active after a minimally invasive heart valve replacement called TAVR. Forty people who had the procedure took part. The goal was to see if these programs are practica…

This study tested whether virtual reality relaxation or binaural beat stimulation can improve sleep and reduce discomfort in 140 adults who had mechanical heart valve replacement. Many patients struggle with sleep due to the sound of the new valve. Participants were randomly assi…

This study tested a new sedative called ciprofol against the standard drug propofol for general anesthesia in 124 older adults undergoing transcatheter aortic valve replacement (TAVR). The goal was to see if ciprofol causes fewer episodes of low blood pressure after anesthesia. R…

This study tested whether a special ultrasound-guided nerve block (PENG block) can reduce pain and the need for extra painkillers in 40 adults undergoing transcatheter aortic valve implantation (TAVI) for aortic stenosis. The block targets nerves around the hip to provide pain re…

This study looked at whether having a nurse talk with patients before and after a heart valve procedure could improve care. About 194 people took part. The nurses helped prepare patients and checked on them afterward, either by phone or in person. The goal was to see if this extr…

This study tested whether using lighter sedation (monitored anesthesia care) instead of general anesthesia with a breathing tube could help people recover faster after a minimally invasive heart valve replacement called TAVR. The trial included 170 adults getting TAVR through a l…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study tests whether using the wrist (radial artery) instead of the groin (femoral artery) as a second access point during a minimally invasive heart valve replacement (TAVI) reduces bleeding and other complications. About 542 patients will be randomly assigned to one of the …

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

Severe aortic stenosis narrows the heart's aortic valve, and current guidelines recommend waiting until symptoms appear before replacing it. But MRI scans show that up to half of patients already have heart scarring by then, which doesn't fully reverse after surgery. This study w…

This study tracks thousands of heart-surgery patients to identify factors that may increase the risk of postoperative delirium — a state of sudden confusion. Researchers are examining whether medications like statins and beta blockers, the use of a heart-lung machine, or the leng…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study looks at whether a substance in the blood called suPAR can help predict serious health events in people with severe aortic stenosis or regurgitation. Researchers will measure suPAR levels and track participants for two years to see if higher levels are linked to death,…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study tested two different methods of closing the main leg artery after a minimally invasive heart valve replacement (TAVR). One method used two small stitch-like devices, the other used one stitch device plus a plug. The goal was to see which approach caused fewer bleeding …

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This study tested a new way to predict dangerous heart rhythm problems after a common heart valve procedure called TAVR. Researchers combined ECG results with CT scan measurements and implant depth to see if they could safely identify low-risk patients. The study looked back at 2…

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This study tracked 300 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVI) to see how long they stayed in the hospital and why some stayed longer than 3 days. The goal was to find out what factors, like needing a blood transfusion or a…

This study looked at whether CT scans can help doctors choose the right size for the Perceval sutureless heart valve. The valve is used to replace a leaky aortic valve. Researchers studied 50 patients to see if CT-based sizing leads to good early results after surgery, like prope…

This study looked at 1,811 patients aged 60-70 who had heart valve replacement surgery. Researchers compared different types of artificial valves to see if the valve type was linked to developing depression, anxiety, or sleep disorders later. The goal was to understand if the cho…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study compared two common sedation drugs, propofol and dexmedetomidine, in 65 older adults undergoing a less invasive heart valve replacement called TAVR. The goal was to see which drug leads to better kidney function, less confusion, and fewer complications after the proced…

This study looked at 22 people with severe aortic stenosis who were scheduled for valve replacement. Before surgery, they had an ultrasound of the heart, and during surgery a tiny sample of heart muscle was taken to check for scarring (fibrosis). The goal was to see if ultrasound…

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This study looked at 70 adults having open heart surgery (aortic valve or bypass). It compared a newer, smaller heart-lung machine to the standard one. The goal was to see which method better protects the body's tissues and the brain during surgery. Results will help doctors choo…

This study looked at 60 heart surgery patients to see how two different bypass machines affect blood flow in tiny vessels under the tongue. One method was minimally invasive, the other was the standard approach. The goal was to find out which technique keeps small blood vessels w…

This study looked at 150 older adults (75+) getting a new heart valve. It compared using a CT scan versus an invasive angiogram to check for blocked arteries beforehand. The goal was to see if the CT scan alone is safe and works just as well, potentially simplifying the process.

This study examined how tiny blood vessels in the heart work after a TAVI procedure, which replaces a narrowed heart valve without open surgery. Researchers measured blood flow and scarring in the heart muscle of 75 patients. The goal was to see if poor small-vessel function is l…

This completed study from RenJi Hospital used a special full-body PET/CT scanner to measure blood flow throughout the body in 34 people: 9 healthy volunteers and 16 patients with severe aortic stenosis and reduced heart function. The goal was to see how blood flow differs between…

This study looked at 86 people with severe aortic valve stenosis who had valve replacement surgery. Researchers used special MRI scans to measure scarring in the heart muscle before and one year after surgery. The goal was to see if the scarring improves and whether MRI could hel…

This study tested whether automated alerts in electronic health records help doctors identify and treat patients with severe aortic stenosis or mitral regurgitation. Over 2,100 patients were included, and some doctors received alerts while others did not. The goal was to see if a…

This study looked at the bacteria living on the skin of 100 patients scheduled for a heart valve replacement procedure called TAVI. The goal was to find out which bacteria are most common in the groin area, where the doctor inserts the new valve. This information can help doctors…

This study tested a program to help people with severe aortic stenosis get a TAVI heart valve procedure faster. The program included a website and booklet for patients, plus better coordination among hospital teams. Researchers measured whether more patients could be treated with…

This study looked back at 198 patients who had a sutureless aortic valve replacement to see how often they developed heart rhythm problems. These newer valves are faster to implant but have a metal frame that might affect the heart's electrical system. The goal was to better unde…

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This study collected information from multiple hospitals on the Cor-Knot® device, which automatically ties knots during heart valve surgery. The goal was to see how safe and effective it is. Over 550 adults having planned valve surgery took part. The main focus was on whether lea…

This study looked at 81 people with mild memory problems who were getting a heart valve replacement (TAVR). Researchers tested their thinking and memory with a 5-minute quiz before the procedure and again 30 days and 6 months after. The goal was to see if fixing the heart valve c…

This study collected blood and tissue samples from 91 adults with aortic valve disease to look for genetic differences that might explain why some develop aortic aneurysms. Researchers compared gene activity in people with bicuspid valves, tricuspid valves, and healthy controls. …

This study looked at how spinal anesthesia changes blood flow and heart function in 44 patients with severe aortic stenosis or mitral regurgitation during valve replacement surgery. Researchers measured the need for drugs that support blood pressure and heart function, as well as…

This study tested a computer program called naevia medical that helps doctors decide the best treatment for heart valve disease. Researchers looked at 106 past patient cases to see if the tool gave better recommendations than usual care. The goal was to see if the tool could redu…

This study followed 77 patients under 60 who had a mechanical aortic valve replacement to see if a mismatch between the valve size and the patient's body affects heart recovery and exercise ability. Participants did exercise tests and heart ultrasounds years after surgery. The go…

This study tested whether two advanced heart ultrasound measures (LACI and LV speckle tracking) can better predict complications like hospital readmission, heart attack, or stroke after TAVI valve replacement. Researchers studied 100 patients with severe aortic stenosis. The goal…

This study watched 258 people getting a new heart valve (TAVR) to see how a device called MANTA closes the large hole in the leg artery. The goal was to check for bleeding problems and how fast the artery seals. No new treatments were tested; researchers just collected real-world…

This completed study looked at 101 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVR). Researchers wanted to see if the procedure was safe for patients who also had an enlarged ascending aorta (≥40 mm). They compared outcomes like dea…

This study tested a strategy to decide which patients need additional artery-opening treatment after a TAVI heart valve procedure. Researchers used a special imaging scan (SPECT) to look for areas of the heart not getting enough blood. The goal was to see if this imaging-guided a…

This study looked at 218 people with severe aortic stenosis (a narrowed heart valve) who needed a procedure called TAVI to replace the valve without open-heart surgery. Researchers compared two approaches: general anesthesia (being fully asleep) versus local anesthesia with sedat…

This study looked at 38 adults who had heart surgery to better understand the heart damage that can occur. Researchers used cardiac MRI scans and blood tests for troponin (a heart damage marker) to measure and compare the extent of injury. The goal was to improve knowledge of how…

This study used a special ultrasound technique called elastography to measure heart muscle stiffness during planned aortic valve replacement surgery. Researchers compared stiffness in patients with aortic stenosis to those having bypass surgery. The goal was to see if aortic sten…

This study looked at 116 patients with severe aortic stenosis and moderate coronary artery disease who were scheduled for valve replacement. Researchers measured blood flow in the heart arteries before, right after, and 6 months after valve replacement to see how the procedure af…