New heart valve shows promise in tight aortic stenosis

NCT ID NCT05478161

Completed Disease control Sponsor: NVT GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new device called the ALLEGRA THV System with a new delivery system (IMPERIA) in 137 people with severe calcified aortic stenosis or a failed surgical valve. The main goal was to see if the valve worked well and was safe 7 days after the procedure. The study confirmed the device performed as intended.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSCATHETER AORTIC VALVE IMPLANTATION

Contacts and locations

Locations

Catharina Hospital

Eindhoven, Netherlands
Erasmus Medical Center

Rotterdam, Netherlands
Herz- und Gefäßzentrum Bad Bevensen

Bad Bevensen, Germany
Hospital Alvaro Cunqueiro

Vigo, 36213, Spain
Hospital Clínico San Carlos

Madrid, Spain
Hospital Universitari de Bellvitge

Barcelona, Spain
Hospital Universitario Virgen de la Victoria

Málaga, Spain
Hospital Universitario de Salamanca

Salamanca, Spain
Maastricht University Medical Center

Maastricht, Netherlands
Schüchtermann Klinik

Bad Rothenfelde, Lower Saxony, 49214, Germany
UKSH, Campus Lübeck

Lübeck, Germany

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