New heart valve trial hopes to offer less invasive option for aortic stenosis patients
NCT ID NCT05804903
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study is testing a new device called the ALLEGRA Plus Transcatheter Heart Valve in 177 people with severe aortic stenosis or a failed surgical valve. The valve is implanted through a catheter, avoiding open-heart surgery. Researchers are checking how safe and effective it is over 12 months, focusing on death and stroke rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ALLEGRA Plus Transcatheter Heart Valve (a device implanted via a catheter to replace the aortic valve)
What this could lead to
If successful, this could provide a less invasive treatment option for people with severe aortic stenosis or a failed surgical valve, potentially improving survival and reducing stroke risk.
What could go wrong
The trial is currently suspended, and it is an early-stage study with only 177 participants. Risks include complications from the procedure, such as stroke or death, and the device may not perform as well as expected.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- TAVI Valve Comparison: Sapien vs Myval (NCT04443023)
- Pacing Methods After TAVI: PHYSTAVI II Trial (NCT06197503)
- Remote Monitoring After TAVI: Same-Day Discharge NCT06602609
- Study on Predicting Heart Conduction Issues Afte NCT07414485
- TAVI Pain Relief: PENG vs Fascia Iliaca Block (NCT06773780)
- NVT ALLEGRA Heart Valve Study (NCT05478161)
Contacts and locations
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Locations
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Deutsches Herzzentrum Berlin
Berlin, 13353, Germany
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Herzzentrum - Luzerner Kantonsspital
Lucerne, 6000, Switzerland
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Hospital La Paz
Madrid, 28046, Spain
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III Katedra Kardiologii
Katowice, 40-635, Poland
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Klinika Kardiochirurgii
Gdansk, 80-214, Poland
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Oulu University Hospital
Oulu, 90220, Finland
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Reina Sofia Hospital
Córdoba, 14004, Spain