New tool could prevent deadly complication during heart valve procedure

NCT ID NCT05666713

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a new tool called TELLTALE designed to safely cut a heart tissue flap during a valve replacement procedure (TAVR). In some cases, this flap can block blood flow to the heart, which is often fatal. The trial involved 90 adults at high risk of this complication. Researchers wanted to see if the new device could successfully and safely perform the cutting step, reducing the risk of blocked arteries and other serious problems.

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Conditions

The condition(s) this trial relates to.

aortic valve disorder aortic valve insufficiency aortic valve stenosis heart valve disorder Hyperthermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • California Pacific Med Ctr

    San Francisco, California, 94109, United States

  • Carilion Medical Center

    Roanoke, Virginia, 24014, United States

  • Emory University

    Atlanta, Georgia, 30308, United States

  • Medstar WHC

    Washington D.C., District of Columbia, 20010, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Rochester Regional Health

    Rochester, New York, 14621, United States

  • St. Francis Hospital and Heart Center

    Roslyn, New York, 11576, United States

  • University of Colorado Health

    Fort Collins, Colorado, 80528, United States

  • University of Washington Heart Institute

    Seattle, Washington, 98195, United States