New tool could prevent deadly complication during heart valve procedure

NCT ID NCT05666713

Completed Disease control Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new tool called TELLTALE designed to safely cut a heart tissue flap during a valve replacement procedure (TAVR). In some cases, this flap can block blood flow to the heart, which is often fatal. The trial involved 90 adults at high risk of this complication. Researchers wanted to see if the new device could successfully and safely perform the cutting step, reducing the risk of blocked arteries and other serious problems.

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Conditions

The condition(s) this trial relates to.

aortic valve disorder aortic valve insufficiency aortic valve stenosis heart valve disorder Hyperthermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE FAILURE VALVULAR HEART DISEASE

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
California Pacific Med Ctr

San Francisco, California, 94109, United States
Carilion Medical Center

Roanoke, Virginia, 24014, United States
Emory University

Atlanta, Georgia, 30308, United States
Medstar WHC

Washington D.C., District of Columbia, 20010, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Rochester Regional Health

Rochester, New York, 14621, United States
St. Francis Hospital and Heart Center

Roslyn, New York, 11576, United States
University of Colorado Health

Fort Collins, Colorado, 80528, United States
University of Washington Heart Institute

Seattle, Washington, 98195, United States

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