Heart valve fix: why some patients still have trouble?

NCT ID NCT05326126

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study examined how tiny blood vessels in the heart work after a TAVI procedure, which replaces a narrowed heart valve without open surgery. Researchers measured blood flow and scarring in the heart muscle of 75 patients. The goal was to see if poor small-vessel function is linked to heart muscle damage, which could explain why some people still feel symptoms after valve replacement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could help doctors better understand why some patients still have heart problems after TAVI, pointing toward new ways to treat or prevent those issues.

What could go wrong

This was a small, observational study that only measured outcomes without testing a new treatment. The findings may not apply to all TAVI patients and need further research to confirm.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • IRCCS San Raffaele

    Milan, 20132, Italy