Aortic disorder

This trial is testing a new stent graft system designed to treat abdominal aortic aneurysms—a bulging, weakened area in the main artery. The device is placed inside the aorta to reinforce the wall and prevent rupture. The study includes adults with infrarenal abdominal aortic ane…

This trial is testing a device called the Heli-FX EndoAnchor system, which is used during minimally invasive repair of abdominal aortic aneurysms (a bulging, weakened area in the main artery). The device helps secure the stent graft in place, potentially preventing leaks or movem…

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This trial asks whether people with severe aortic stenosis can safely go home the same day after a minimally invasive heart valve replacement (TAVI) instead of staying in the hospital. About 764 patients who are stable six hours after the procedure will be randomly assigned to ei…

This trial tests whether wearing a portable heart monitor for two weeks after a TAVI procedure can reduce the risk of sudden death, dangerous heart rhythms, or stroke within the following year. People who have had a successful TAVI and show certain electrical abnormalities on the…

This trial tests whether angiotensin receptor blockers (ARBs), a type of blood pressure medication, can reduce the risk of death or heart failure in people who have had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis and still have a thickened heart mus…

This trial is testing a new device called the Crea Aortic Valve, a replacement heart valve that can be implanted through a catheter without open-heart surgery. It is designed for people aged 60 and older with severe aortic stenosis—a narrowing of the heart's main valve—who are co…

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover better after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months. The goal is to see if these me…

This study looks at different methods to restore blood flow to the left subclavian artery when it must be covered during aortic repair. Covering this artery can raise the risk of stroke and arm problems. The trial compares surgical bypass with newer endovascular techniques to see…

This clinical trial is testing a new heart valve replacement system called Encantor, which uses software to guide placement of the valve. The study includes 150 adults with severe aortic stenosis who are candidates for a minimally invasive procedure. Researchers will track how ma…

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This pilot study tests whether a three-week inpatient cardiovascular rehabilitation program, started three months after abdominal aortic aneurysm repair, improves cardiorespiratory fitness more than standard post-operative care. Researchers will measure changes in maximal oxygen …

This trial tests whether a newer balloon-expandable heart valve with intermediate sizes (Myval) is as safe as a standard self-expanding valve (Evolut) in people with severe aortic stenosis whose valve measurements fall in a 'borderline' range. About 600 participants will be rando…

This study tests whether a short, controlled clamping of the aorta before aneurysm surgery can prevent acute kidney injury. About 206 patients will be randomly assigned to receive this preconditioning or standard care. The goal is to see if this simple procedure lowers the risk o…

This study looks at a device called ShortCut that splits old heart valve leaflets before placing a new valve inside it. The goal is to keep the arteries open and prevent blockages. About 150 people with aortic stenosis who are at risk for this complication will take part. Researc…

This trial tests a new type of stent that dissolves over time for children under 9 with narrowed arteries in or near the heart. The stent opens the vessel and then gradually disappears, allowing the artery to grow naturally. The study will enroll 45 children and follow them for 5…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This early study tests a new device called the GORE Multibranch Arch Endoprosthesis for people with aortic arch conditions like aneurysms or dissections. The device is placed inside the blood vessel to repair the damaged area. The study will enroll 20 participants and follow them…

This study looks at whether a common heart valve procedure called TAVI is safe when done in hospitals that don't have heart surgery available on-site. About 600 people with severe aortic stenosis will be randomly assigned to have TAVI either with or without surgical backup. The g…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…

This study looks at how safe and effective the SAPIEN 3 heart valve is for people with a certain type of bicuspid aortic valve stenosis (Type-0). About 170 people in China will be observed after the procedure to track serious problems like death, stroke, or rehospitalization. The…

This study compares a new heart valve implant (Myval) to standard medication in 778 people aged 65+ with moderate aortic stenosis. The goal is to see if the implant reduces death, stroke, heart failure, and improves quality of life over 2 years. Participants will be randomly assi…

This study tests whether covered stents are better than bare metal stents for people with narrowed kidney arteries caused by atherosclerosis. About 150 participants will be randomly assigned to one stent type and followed for 12 months to see changes in kidney function and blood …

This study looks at people with narrowed kidney arteries and high blood pressure. It uses a special pressure measurement (FFR) to decide who gets a stent and who gets only medication. The goal is to see which approach better protects kidney function and controls blood pressure ov…

This trial compares two latest-generation heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) in 200 patients with severe aortic stenosis. Participants will be randomly assigned to receive one valve during a standard procedure and followed for one year. The goal is to see which v…

This study tests whether using only ultrasound (echocardiography) to guide a minimally invasive heart valve replacement is as effective as the standard method that combines X-ray and ultrasound. The goal is to reduce kidney injury from contrast dye and lower radiation exposure. A…

This registry will follow 200 people with severe aortic valve stenosis who receive a non-invasive ultrasound therapy called Valvosoft. The treatment uses focused sound waves to soften calcium buildup on the valve without surgery. Researchers will track safety and effectiveness fo…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This trial is for people whose surgically implanted aortic heart valve has stopped working properly. It compares two types of replacement valves placed through a tube in the leg (TAVI): a newer self-expanding valve (Hydra) versus standard balloon-expandable valves (Sapien or MyVa…

This study looks at whether a common heart valve replacement (TAVI) can be performed safely in hospitals that do not have a cardiac surgery team on-site. Currently, TAVI is only done in hospitals with heart surgery backup, which can cause long wait times. The trial will randomly …

This study tests whether a drug called a PCSK9 inhibitor (Tafolecimab) can slow the progression of mild to moderate calcific aortic stenosis, a condition where the heart valve narrows and hardens. Researchers will give the drug to half of 160 participants and compare changes in v…

This study follows about 300 patients across Europe who need a second minimally invasive heart valve replacement (TAVI-in-TAVI) because their first valve has worn out or is leaking. Doctors will use the Myval valve for the replacement. The study will track how well the procedure …

This study tests whether a daily low-dose anti-inflammatory drug (colchicine) can prevent blood clots from forming on replacement heart valves after a minimally invasive valve procedure (TAVR). About 116 people who have had TAVR will either receive colchicine plus standard care o…

This study tests a new way to replace a leaky heart valve (aortic regurgitation) without using X-rays or contrast dye, which can harm the kidneys. Instead, doctors will use only ultrasound (echocardiography) to guide the procedure. The goal is to see if this approach is safe and …

This study tests a new device called the J-Valve Transfemoral System in 50 adults who have a heart pump (LVAD) and a severely leaking aortic valve. The valve is replaced through a blood vessel, avoiding open-heart surgery. The goal is to see if it safely stops the leak and improv…

This study tests a new way to replace the aortic valve in people with a leaky heart valve (aortic regurgitation) without using X-rays or contrast dye. Instead, doctors will rely on ultrasound (TEE) to guide the procedure. The goal is to see if this approach is safe and effective,…

This study will test whether giving an extra antibiotic during a heart valve replacement procedure (TAVI) can lower the chance of bloodstream infection or death within 6 months. About 2,000 patients in Denmark will take part. Half will get the standard antibiotic, and half will g…

This study tests whether adding a second balloon inflation (called 'double tap') after placing a new heart valve improves how well the valve opens and works. About 250 adults with severe aortic stenosis getting a TAVI procedure will be randomly assigned to receive the standard pr…

This study tests a 'Fast-Track' approach for repairing abdominal aortic aneurysms using local anesthesia, small incisions, and avoiding the ICU. The goal is to see if patients can safely go home in less than 48 hours, reducing hospital costs and freeing up beds. About 50 people w…

This study tests whether taking aspirin after a minimally invasive aortic arch repair can prevent strokes, a common complication. 224 patients will be randomly assigned to take aspirin for 3, 6, or 12 months. The researchers will track stroke rates, bleeding risks, and other outc…

This study tests a new device called the TAVR Assist System, which helps doctors perform a heart valve replacement procedure (TAVR) for severe aortic stenosis. The trial will compare the assist system to the standard manual TAVR in 158 older adults. The goal is to see if the devi…

This registry will follow 500 adults who need surgical replacement of their aortic or mitral heart valve with a Dafodil bioprosthetic valve. The study collects real-world data on survival, valve function, and complications like blood clots or infection over 5 years. It aims to he…

This trial tests a new device called the ArcFlex Sheath, a bendable tube used during TAVR surgery to replace a faulty aortic valve. The goal is to see if it helps doctors position the new valve more easily and safely compared to a standard sheath. About 180 people who need TAVR s…

This study tests a new stent graft device in 100 people with a bulging iliac artery (aneurysm). The device is placed inside the artery to support it and prevent rupture. Researchers will track serious complications like stroke, heart attack, or kidney problems over time to see if…

This study is testing three types of Bentley stent grafts used to repair complex abdominal aortic aneurysms. Researchers will follow 150 adults for 12 months to see how well the grafts work and if there are any side effects. The goal is to improve the safety and success of this m…

This study tests whether giving dry plasma to people with massive bleeding before they reach the hospital can improve survival. Researchers will compare dry plasma to standard fluids in 650 adults with signs of bleeding shock. The main goal is to see if more people survive the fi…

This early study tests a tele-operated robot called TAVIPILOT that helps doctors position a new heart valve during a minimally invasive procedure called TAVR. Ten patients aged 65 and older with severe aortic stenosis will take part. The main goals are to see if the robot is safe…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study tests a special silver-coated mesh placed during emergency abdominal surgery to see if it can prevent surgical site infections and incisional hernias. About 110 adults having urgent open abdominal surgery will take part. Researchers will track infection and hernia rate…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This trial tests whether two heart medications, metoprolol and amiodarone, can prevent new-onset atrial fibrillation (AFib) in people who develop minor rhythm issues after transcatheter aortic valve replacement (TAVR). About 198 participants will be randomly assigned to one of th…

This study tests whether giving steroids before a major aortic repair surgery (TEVAR) can prevent postimplantation syndrome—a flu-like inflammatory reaction that often leads to longer hospital stays and serious heart problems. About 174 adults scheduled for elective aortic repair…

This study tests whether giving a special fluid (colloid) before anesthesia can prevent blood pressure drops in 116 people undergoing transcatheter aortic valve replacement (TAVR). Participants will receive either the colloid or a standard salt solution before anesthesia. The goa…

This study tracks discomfort in 132 people who had endovascular repair for aortic dissection. It measures pain, skin issues, stress, and self-care problems. Some patients will receive extra education after surgery to see if it reduces these symptoms.

This study compares two types of heart valve surgery: a newer, less invasive method through a small cut on the right side of the chest versus the traditional method through a cut down the middle of the chest. Researchers will measure how quickly patients recover, including time o…

This study tracks 100 people in the UK who are getting a TAVI procedure to replace a narrowed heart valve. Researchers will measure how the procedure affects their quality of life, mental health, and thinking skills over one year. The goal is to understand the real-world benefits…

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known a…

This study looks back at medical records of about 350 people who had a specific stent graft placed during a complex aortic surgery called a frozen elephant trunk procedure, used to treat aortic aneurysms or dissections. The goal is to see how often major complications like stroke…

This study tests whether wearable devices and artificial intelligence can help personalize the timing of valve replacement in people with moderate to severe aortic stenosis who have no symptoms. Participants wear a smartwatch to track heart rate, activity, and blood pressure, and…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will use a special scan to look for B cells (a type of immune cell) in the blood vessels of 30 people with giant cell arteritis, a serious disease that can cause blindness or stroke. Current treatments rely on steroids, which have harsh side effects. If the scan works,…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study will follow 500 people with severe aortic stenosis who need a heart valve replacement. Researchers want to see if a dedicated Heart Valve Unit—a team of heart specialists working together—can reduce confusion, delirium, and memory problems that sometimes happen after t…

This registry will follow 400 people with complex aortic aneurysms who are treated with GORE devices that help keep blood flowing to vital organs. The goal is to see how well the devices work and how safe they are in everyday medical practice. Participants must need at least one …

This study will compare two common types of heart valves used in TAVI (a procedure to replace a narrowed aortic valve) to see which one sends fewer tiny particles to the brain during the procedure. 80 adults with severe aortic stenosis will be randomly assigned to receive either …

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study watches babies under 3 months old who are having surgery to fix a narrowed heart artery. Doctors will check if a special monitor that measures blood flow matches other standard checks. No extra treatments or changes to care are involved.

This study observes 600 people with aortic stenosis who cannot have a standard TAVI procedure through the leg artery. Instead, doctors will use other access points, like the chest or neck, to replace the heart valve. The goal is to track safety and success rates of these alternat…

This study tests whether evolocumab, a drug that lowers 'bad' cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will receive either the drug or a placebo before surgery. Researchers will then compare the tiss…

This study looks at whether people who have had a ruptured brain aneurysm also have an abdominal aortic aneurysm (a bulge in the main belly artery) that they don't know about. About 233 participants will get a painless belly ultrasound to check. The goal is to see how common this…

This study looks at whether advanced heart pressure wave analysis can predict how well patients recover after a TAVR procedure for severe aortic stenosis. Researchers will measure pressure waves during the procedure and track quality of life and heart complications over one year …

This study will look at 800 patients who had aortic surgery to understand why some develop dangerous blood clots inside the repaired artery. Researchers want to find out how common these clots are, what puts patients at risk, and how they affect recovery. The goal is to improve c…

This study will use special CT scans that track both the heartbeat and breathing to see how a stent graft moves inside the abdominal aorta after aneurysm repair. Twenty-five patients with complex aneurysms will be scanned before surgery, at discharge, and at 6 and 12 months after…

This study will observe 143 older adults with severe aortic stenosis who are scheduled for a minimally invasive valve replacement procedure called TAVR. Researchers want to find out how many also have cardiac amyloidosis, a condition where abnormal proteins build up in the heart.…

This study compares two established techniques for placing a TAVI heart valve to see which one better aligns the valve with the patient's own valve openings, reducing the risk of blocking coronary arteries. Forty patients with severe aortic stenosis will be randomly assigned to o…

This study will collect data from 1100 people with peripheral artery disease or abdominal aortic aneurysm across six European centers. Researchers will use artificial intelligence to analyze clinical data, blood samples, imaging, and wearable device information to build tools tha…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …