Gentle second chance: new Valve-in-Valve study for failing heart valves
NCT ID NCT07215143
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows about 300 patients across Europe who need a second minimally invasive heart valve replacement (TAVI-in-TAVI) because their first valve has worn out or is leaking. Doctors will use the Myval valve for the replacement. The study will track how well the procedure works and any complications over up to five years, using information from routine medical care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Myval transcatheter heart valve (OctaCor/OctaPRO)
What this could lead to
If successful, this could show that a second TAVI procedure with the Myval valve is a safe and effective alternative to repeat open-heart surgery for patients whose first valve has worn out.
What could go wrong
This is an observational study, not a randomized trial, so it cannot prove the Myval valve is better than other options. Results depend on routine care data, which may be incomplete. The procedure itself carries risks like any heart valve replacement.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.