University Of Chicago

This study tests two types of support for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation, and the other gets extra help finding a job and money for health and career goals. The goal is to see which approach helps…

This study tests whether two common immunotherapy drugs, nivolumab and pembrolizumab, can be given less frequently than the current standard schedule for people with advanced cancers. Researchers will compare drug levels in the blood to see if extended dosing keeps the drugs effe…

This study tests whether a blood test that tracks tumor DNA can help doctors decide when to add short bursts of chemotherapy to standard immunotherapy for people with recurrent or metastatic head and neck cancer. About 30 adults will receive pembrolizumab (immunotherapy) plus occ…

This study is for people whose multiple myeloma has returned or stopped responding to standard treatments, including CAR T-cell therapy. Researchers want to see if combining four drugs—belantamab mafodotin, carfilzomib, pomalidomide, and dexamethasone—can shrink the cancer or slo…

This study tests a combination of the experimental drug volrustomig with standard chemotherapy (paclitaxel and carboplatin) in people with untreated, locally advanced HPV-negative head and neck cancer. After initial treatment, the next steps are tailored based on how well the tum…

This early-phase study tests a combination of two drugs—selumetinib and azacitidine—in adults with higher-risk blood cancers like myelodysplastic syndromes (MDS) and myelofibrosis. The main goal is to find the safest dose of selumetinib when given with standard azacitidine. Up to…

This study tests a new surgical method called PoRSHA for repairing large or recurrent paraesophageal hernias. Instead of using synthetic mesh, surgeons use a flap of the patient's own abdominal lining to reinforce the weakened diaphragm. The goal is to see if this approach reduce…

This study looks at whether a spinal cord stimulator can reduce pain and improve blood vessel health in people with type 2 diabetes who have nerve pain in their legs. About 25 adults with diabetes for over a year and poor circulation will get the device. Researchers will check pa…

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or control advanced anal or rectal cancer that has spread and no longer responds to standard chemotherapy. About 35 adults with this type of cancer will receive the combination. The goal is to see how ma…

This study tests a new combination of drugs and radiation for people whose head and neck cancer has returned after previous treatment. The goal is to find the safest dose and see how well the treatment works. About 30 participants will receive the drugs tislelizumab and pamiparib…

This study tests whether two drugs, phenylephrine and vasopressin, can lower the risk of dangerous heart rhythm problems in ICU patients with shock compared to standard drugs norepinephrine and epinephrine. About 836 adults with shock not improving after fluids will be randomly a…

This early-phase study tests whether adding ivosidenib to the standard drug ruxolitinib is safe and effective for people with advanced myeloproliferative neoplasms (MPNs) that have an IDH1 mutation. About 18 adults with these rare blood cancers will receive the combination to fin…

This study is for people newly diagnosed with extensive-stage small cell lung cancer that has spread. Researchers want to see if adding focused radiation to the standard treatment of durvalumab and chemotherapy can help people live longer without their cancer getting worse. About…

This study tests a new drug called tegoprubart in people with type 1 diabetes who have dangerous low blood sugar episodes and are getting islet cell transplants. The drug aims to prevent the immune system from attacking the transplanted cells without using standard anti-rejection…

This study tests a specific chemotherapy combination (epirubicin/cyclophosphamide followed by docetaxel/carboplatin) in 85 Nigerian women with triple-negative breast cancer. The goal is to see how many have no cancer left in the breast or lymph nodes after treatment. Researchers …

This early-stage study tests whether adding fulvestrant to standard radiation therapy (Lu-DOTATATE) can better control advanced pancreatic neuroendocrine tumors. About 25 adults with tumors that cannot be surgically removed will receive the combination. The main goals are to chec…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with brittle type 1 diabetes achieve safer blood sugar levels without needing insulin shots. Up to 20 adults aged 18-70 will receive the cells through a vein and be monitored…

This study tests whether taking aspirin after childbirth can prevent heart damage in women who had preeclampsia, a serious pregnancy condition. Researchers will measure heart function and blood markers in 180 women over 6 months. The goal is to see if aspirin can reduce inflammat…

This study tests whether adding the drug relacorilant to standard hormone therapy and enzalutamide can better shrink high-risk prostate cancer before surgery. About 90 men with advanced, localized prostate cancer that hasn't spread will take the drug combination or a placebo for …

This early-phase study tests a new three-drug combination for people with head and neck cancer that has come back or spread. The goal is to find the safest dose and see if the treatment can shrink tumors or slow the disease. About 36 adults with this type of cancer will take part…

This study tests whether closing a small opening in the diaphragm (hiatal closure) can control early GERD. Researchers will enroll 40 adults aged 18-50 with mild reflux and a small hiatal defect. Participants will have surgery to close the defect, and the study will measure if th…

This study tests whether having a trusted friend or family member (a 'support confidant') can help people with HIV keep their doctor appointments and lower their virus levels. Researchers will enroll 900 people aged 18-49 in Chicago and Alabama who have missed appointments or had…

This early-phase study tests a powerful mix of five chemotherapy drugs for people with advanced cancers of the pancreas, stomach, bile ducts, or gallbladder that have not been treated yet. The researchers use a genetic test to adjust the dose of one drug (irinotecan) based on how…

This study tests a new experimental drug, LP-118, combined with three other medicines (ponatinib, vincristine, and dexamethasone) in adults with T-cell acute lymphoblastic leukemia or lymphoma that has come back or not responded to treatment. The goal is to find a safe dose and s…

This study is for adults with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL) that has come back or not responded to treatment. Researchers are adding a drug called capivasertib to a standard chemotherapy regimen (mini-hyperCVD plus venetoclax) to see if it is …

This study tests whether giving the drug toripalimab with chemotherapy before surgery or a lower dose of radiation can shrink HPV16-positive throat cancer tumors. About 30 adults with advanced but not spread throat cancer will take part. The goal is to see if this approach improv…

This study tests whether a behavioral program combined with a smartphone app can help young adults (ages 18-40) who are overweight or obese lose weight. Researchers will track weight changes over 6 months. The goal is to find a more effective way to help people manage their weigh…

This early-phase study tests whether a new drug called tegoprubart, along with other medications, can safely help islet cell transplants work better in people with type 1 diabetes and chronic kidney disease. About 10 adults will receive the transplant and take immunosuppressants …

This early-stage trial tests whether giving a mix of healthy gut bacteria to people hospitalized with liver disease is safe and tolerable. The bacteria come from healthy donors and are designed to restore missing gut microbes. 24 adults with liver failure or cirrhosis will receiv…

This study tests a low dose of tocilizumab, a drug used for arthritis and COVID-19, to treat acute chest syndrome in people with sickle cell disease. Researchers believe it may help improve oxygen levels and reduce the need for blood transfusions. The trial enrolls 200 adults age…

This early-phase study is testing whether adding the targeted drug ruxolitinib to standard chemotherapy is safe for adolescents and young adults (ages 12-39) with a specific high-risk type of acute lymphoblastic leukemia (Ph-like ALL). The trial aims to find the best dose and che…

This study is testing whether using MRI scans to guide radiation can lower the dose to healthy parts of the prostate while giving a higher dose to cancer spots. The goal is to reduce bowel-related side effects and preserve quality of life. About 60 men with intermediate- or high-…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AF) in overweight or obese adults. About 200 people aged 18-75 with AF and a BMI of 30 or higher will receive semaglutide alongside standard AF care. The goal is to see …

This study is for Nigerian women with a specific type of breast cancer called HER2-positive. Doctors want to see if giving a combination of targeted drugs before and after surgery can destroy the cancer completely. About 74 women will receive the treatment, and researchers will c…

This study tests whether transplanting insulin-producing islet cells from deceased donors can help people with type 1 diabetes who have already had a kidney transplant. The goal is to achieve better blood sugar control without needing insulin shots. Ten participants aged 18 to 68…

This study is testing whether regular MRI scans can find aggressive prostate cancers earlier in men who are at high risk. Researchers will follow 250 men for up to 15 years, scanning them every 3 years. The goal is to see if MRI can detect high-grade cancers sooner than standard …

This study is testing whether a quick, painless measurement of muscle activity can help doctors diagnose ALS earlier and more accurately. Researchers will compare this new test to current methods in 650 people with muscle symptoms. They will also track how the test changes over t…

This study looks at whether a non-invasive stool test (FIT) can accurately detect colorectal cancer in people with Lynch Syndrome, a genetic condition that raises cancer risk. Researchers will compare FIT results to standard colonoscopy findings in 400 participants. If accurate, …

This study checks if a simple finger prick test can accurately detect current or past Toxoplasma infection, compared to standard lab blood tests. About 210 adults, including pregnant women, will take part. The goal is to see if the finger prick test is reliable enough for wider u…

This study is testing a new computer software that creates risk maps from MRI scans to help doctors decide if a prostate biopsy is needed. About 180 people with known or suspected prostate cancer will have one MRI and one or two biopsies, and be followed for a year. The goal is t…

This study tests four practical strategies—training clinic staff, educating patients, improving electronic health records, and assigning patient navigators—to help more Black women start and stay on PrEP, a daily pill that prevents HIV. About 680 HIV-negative women aged 18 and ol…

This study looks at whether a surgery called immediate lymphatic reconstruction (ILR) can prevent lymphedema—painful arm swelling—in women having lymph nodes removed during breast cancer treatment. Researchers will measure arm size and fluid levels in 90 participants to see if th…

This study tests whether eating a high-fiber, low-fat diet for three weeks before colorectal cancer surgery can change gut bacteria to help prevent the cancer from coming back or spreading. About 80 adults with colorectal cancer will follow this diet and provide blood, stool, and…

This study tests whether empagliflozin, a drug used for diabetes and heart conditions, can help prevent calcium kidney stones. Researchers will give the drug daily for 4 weeks to 32 adults who have had calcium oxalate or calcium phosphate stones. They will measure changes in urin…

This study tests if placing amiodarone directly into the sac around the heart during bypass or valve surgery can prevent a common complication called atrial fibrillation. About 63 adults aged 20-85 will be monitored continuously after surgery. The goal is to reduce irregular hear…

This study tests a new surgical technique called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal for breast cancer. The goal is to prevent lymphedema, a painful arm swelling that can happen after surgery. Researchers will follow 100 women to s…

This study tests whether Astepro nasal spray can help manage early COVID-19 symptoms and lower the amount of virus in adults. About 280 people with a positive COVID-19 test will use the spray or a placebo for 10 days. Researchers will track symptoms, viral load, and whether the s…

This study tests a pre-surgery exercise and support program (prehab) for 100 frail or pre-frail adults who need chest surgery. The goal is to see if the program helps patients get stronger before surgery, leading to fewer complications and a faster return home. Researchers will t…

This early study tests whether a special nerve-stimulating device can restore touch sensation to the breast area and reduce chronic pain in people who have had both breasts removed. Eight adults scheduled for mastectomy with reconstruction will take part. The goal is to see if th…

This study is testing a shorter course of pelvic radiation for women with endometrial cancer. The goal is to see if giving slightly higher daily doses over fewer days is safe and causes fewer bowel and bladder side effects. About 100 women who have had surgery for non-spreading c…

This study tests whether the anti-inflammatory drug ibuprofen can lower elevated PSA levels in men. High PSA often leads to biopsies, but inflammation may cause false alarms. Researchers will give ibuprofen to 200 men with high PSA and no known cancer, then measure changes in PSA…

This study looks at whether giving caffeine can help children wake up more quickly after being sedated for an MRI. Children aged 3 to 12 who need an MRI will receive either caffeine or a placebo. The goal is to see if caffeine shortens the time it takes for them to be alert and r…

This study tests a web-based program called OMGYES.com to see if it helps young adult female cancer survivors who have sexual problems. About 30 participants will use the online modules at home and visit the clinic every 5 weeks to fill out questionnaires. The goal is to see if t…

This study tests an 8-week home program for minority women with bladder control problems. The program includes exercises, behavior changes, and support from a chatbot. Researchers want to see if it helps reduce symptoms and is easy to use. About 80 women will take part.

This study tests whether numbing a specific nerve in the knee (a nerve block) provides better pain relief after surgery for a broken knee bone compared to the standard approach of numbing only the surgical cut. Researchers will measure pain levels and painkiller use in 38 adults …

This study looks at how long people should wear a cast after thumb arthritis surgery. Some participants will wear a cast for 2 weeks, others for 6 weeks. The goal is to see which recovery time leads to less pain and better hand function. About 90 adults aged 40 and older will tak…

This study looks at whether regularly screening for diabetes-related emotional distress can help adults with type 2 diabetes improve their blood sugar and cholesterol. About 1,250 adults with type 2 diabetes and high blood sugar will take part. The goal is to see if addressing em…

This study tests whether a simple, non-needle ear acupressure technique can help people preparing for major lung surgery feel better and get stronger. Researchers will enroll 40 adults aged 50 and older who are waiting at least two weeks for surgery. Participants will have small …

This study tests whether using a freeze spray (ethyl chloride) before a corticosteroid injection can reduce pain and anxiety. About 300 adults receiving their first joint or soft-tissue injection will rate their pain and satisfaction. The goal is to see if this simple spray makes…

This study tests whether placing a numbing drug (bupivacaine) into the bladder after kidney stone surgery can lower pain and improve recovery. About 116 adults will receive either the drug or a saltwater placebo. The goal is to see if this simple step reduces pain, bladder spasms…

This study tests whether watching educational videos can help older adults (65+) with bladder cancer avoid problems like trouble moving, medication issues, and low quality of life after bladder removal surgery. About 85 participants will watch the videos and answer surveys. The g…

This study looks at whether a limited surgery to remove part of the lung lining (partial pleurectomy) can reduce symptoms and improve quality of life for people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and report…

This study is for people with multiple myeloma whose doctors recommend radiation. Normally, radiation takes 2-3 weeks, but this trial tests a shorter course (hypofractionation) with slightly higher daily doses to see if it is safe. About 30 participants will receive pelvic radiat…

This study looks at whether adding guided spiritual care sessions to standard hospital care is possible and helpful for adults with acute leukemia. About 70 participants will be randomly assigned to either receive these sessions or usual care. The goal is to see if patients accep…

This study compares a continuous cooling therapy device to traditional ice packs for pain relief after open carpal tunnel surgery. About 128 adults having the procedure will rate their pain and hand function. The goal is to see if the cooling device offers better pain control.

This study looks at women with urgent bladder control problems who choose a nerve stimulation device. It compares a 3-day test period to the usual 7-day test to see if the shorter time works just as well. The goal is to make the process faster and more convenient without reducing…

This study looks at whether giving doctors genetic information about their patients before surgery can help them choose safer medications. About 1900 adults having elective surgery at the University of Chicago will provide a blood sample for genetic testing. Some doctors will rec…

This study looks at how gluten affects the gut in people with celiac disease, focusing on tissue damage and healing. Researchers will study 220 adults, including those on a gluten-free diet, those with symptoms not on the diet, and healthy controls. The goal is to better understa…

This study is creating a registry of up to 100 adults with knee osteoarthritis to track how well a procedure called genicular artery embolization (GAE) reduces pain over 12 months. Participants have had knee pain for over 6 months that hasn't improved with standard treatments lik…

This study aims to create a registry of 400 women at high risk for breast cancer to test whether a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will be scanned every 6 months. The goal is to develop a personalized, faster scre…

This study looks at whether HPV DNA can be found in the blood of people with HPV-related anal or cervical cancer before, during, and after radiation therapy. Researchers will collect blood samples and tumor tissue to see if changes in HPV DNA levels can help predict if the cancer…

This study looks at whether a two-day employment program helps young Black sexual minority men stay engaged in HIV care. About 132 participants will attend the program and complete surveys over 13 months. Researchers want to see if the program is acceptable and feasible, and if i…

This study looks at how the heart's performance relates to recovery in people with severe brain injuries or brain bleeds. Researchers will collect data from standard monitors already used in the ICU and follow up with participants 6 months after they leave the hospital. The goal …

This study looks at whether community health workers can share true health information on social media using personal stories. About 1,400 health workers and their followers will take part. The goal is to see if this approach helps people decide to get vaccines and protect themse…

This study looks at 100 adults who need a blood clot filter (IVC filter) removed. Doctors will compare two common removal methods: using a snare device or rigid forceps. The goal is to see which method works better and faster, and which has fewer complications.

This study tests a faster way to diagnose and manage PTSD in primary care clinics on Chicago's South Side. Researchers will track how many people are screened, diagnosed, and treated for PTSD. The goal is to improve care for those affected by trauma.

This study works with community organizations in Chicago to find out what makes it hard for people to quit smoking and what kind of help they need. Researchers will create a community advisory board and test a new smoking cessation program in a behavioral health center. The goal …

This study compares two ways of aiming radiation at brain tumors that have spread from other cancers. Half the participants get the standard extra 2 mm safety margin around each tumor, while the other half get no extra margin. The goal is to see if skipping the margin keeps tumor…

This study is looking at whether a special MRI measurement of muscle health, called the muscle assessment score (MAsS), can help predict serious outcomes like death or the need for a liver transplant. Researchers will follow 1,200 adults with liver disease who are already schedul…

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will monitor 40 participants using continuous glucose monitors to see if sleep apnea makes blood sugar harder to control. The goal is to b…

This study looks at whether measuring how older adults walk at home can help doctors understand their recovery after major abdominal surgery. Researchers will track 100 participants aged 60 and older using their mobile devices and special sensors. The goal is to find better ways …

This study looks at whether giving doctors genetic information about their African American patients can help them prescribe medications more safely, especially the blood thinner warfarin. Researchers will track how often doctors use this genetic guidance and whether it leads to …

This study looks at how a person's neighborhood resources affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce the numbe…

This study collects blood and tissue samples from 500 people having heart surgery at the University of Chicago Medical Center. Researchers will study these samples to learn more about heart disease and how to improve treatments. Participants do not receive any new treatment—they …

This study looks at how changes in gut bacteria caused by COVID-19 might lead to long-lasting symptoms like fatigue, brain fog, and stomach issues. Researchers will collect stool and blood samples from 400 adults—half with long COVID and half without—to compare their gut health. …

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will measure changes in urine levels after giving potassium citrate to 24 adults, some with a history of kidney stones and some without. The go…

This study aims to find the genes that cause inherited heart and muscle diseases, such as cardiomyopathy, arrhythmia, and muscular dystrophy. Researchers will analyze DNA from patients and their families to identify mutations. The goal is to better understand these conditions, no…

This study looks at how two natural compounds in food—oxalate and citrate—affect the chance of forming kidney stones. Researchers will measure changes in urine after participants consume sodium oxalate. The goal is to better understand why some people get stones and others don't.…

This study tests a computer program that predicts when dangerous brain pressure or low oxygen levels will occur in people with severe traumatic brain injury. The goal is to give doctors a warning so they can treat the problem before permanent damage happens. About 120 adults will…

This observational study looks at how kidney stones, insulin resistance, and inflammation are related. Researchers will measure belly fat and blood markers in 20 people who have had calcium kidney stones (but not diabetes) and 20 healthy people. The goal is to understand why kidn…

This study looks at adults with cirrhosis who are waiting for a liver transplant but do not have diabetes. The goal is to find out if simple tests like blood work, glucose monitors, and activity trackers can predict who will develop diabetes after the transplant. Participants wea…

This study looks at how well a person's own fat works for rebuilding the breast or chest wall after surgery. Fifteen adults who are already planning this procedure will have 3D photos, ultrasound, and MRI scans taken before and 3-6 months after. They will also fill out a question…

This study looks at how diet and being male or female change the risk of kidney stones in people who have had gastric bypass surgery. About 28 participants will eat a special diet for six days and visit a clinic three times. The goal is to measure urine changes that can lead to k…

This study compares two types of metal rods used to fix broken shinbones (tibia fractures). One rod is standard, the other allows tiny movements (micromotion) at the break site. Researchers want to see which rod helps the bone heal faster and with fewer problems. About 372 adults…

This study looks at whether adding a PSMA PET scan to the usual MRI scan can better find prostate cancer that has come back after focal therapy (a treatment that targets only the tumor). About 62 men who have had focal therapy will get both scans. The goal is to see if the PSMA P…

This study looks at whether checking a person's genes before prescribing painkillers can lead to better pain control and fewer medication changes. About 800 cancer patients who are expected to need opioids will be randomly assigned to receive genetic testing or usual care. The go…

This study is testing whether adding blood and urine tests (biomarkers) to a computer risk score can better predict which hospitalized patients will develop severe acute kidney injury (AKI). About 800 adults at high risk will be enrolled at two hospitals. Researchers will collect…

This study looks at how knowing or not knowing you took a tiny dose of LSD (13 micrograms) changes your mood, behavior, and decision-making. Healthy adults will be split into four groups: some are told exactly what they get (LSD or placebo), others are kept uncertain. Researchers…

This study looks at whether giving heated chemotherapy directly into the abdomen during keyhole surgery can increase a protein called PD-L1 in stomach cancer that has spread to the lining of the belly. PD-L1 helps doctors decide if immunotherapy might work. The trial involves 21 …

This study aims to create and test a personalized support program for women aged 40-58 going through menopause who have a higher risk of dementia due to a family history. The program will help them manage fears about dementia and learn healthy coping skills. Researchers will firs…

This study looks at a new way for hospitals to quickly evaluate stroke patients and decide if they need to be transferred to a specialized center. The goal is to reduce the time it takes from arrival at the first hospital to departure for advanced care. Researchers will track how…

This study is testing a mobile health app designed to help young adults (ages 18-26) quit using e-cigarettes and other nicotine products. About 46 participants who vape regularly and want to quit will use the app and be tracked for 7-day quit success, confirmed by a saliva test. …

This study looks at whether a 12-week education and support program can help African American patients with advanced chronic kidney disease learn more about their condition and how to manage it. About 180 hospitalized adults will either receive the program or standard care. The g…

This study looks at whether people with ulcerative colitis (UC) who are in deep remission can safely reduce or stop their medication without the disease coming back. About 200 adults with UC will either continue their current therapy or de-escalate (decrease or stop) it, based on…

This study tests whether a special clinic that checks your genes and medications can lower the chance of harmful drug interactions. About 1,300 adults with cancer or mental health conditions who take multiple medications will participate. Researchers will compare how well the cli…

This study collects lung tissue from patients awaiting a lung transplant to better understand what causes pulmonary fibrosis, a disease that scars the lungs. Researchers will examine cells and proteins in the tissue to find clues about the disease. The study does not offer any tr…

This study looks at whether a treatment called hypoglossal nerve stimulation (HGNS) for obstructive sleep apnea can improve how the body processes sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will take part. Researchers will measu…

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…

This study looks at whether older men (70+) with prostate cancer who have been on hormone therapy for over three years can stop taking it. The idea is that their bodies may no longer produce testosterone, making the treatment unnecessary. Researchers will monitor testosterone lev…

This study collects tissue and blood samples from up to 1,000 people with stomach, esophageal, pancreatic, liver, gallbladder, and other gastrointestinal cancers. The samples are stored and used to create a database for researchers to study the biology of these cancers. Participa…

This study looks at how working a 24-hour shift affects the immune system of surgery residents. Researchers will measure changes in immune cells and inflammation before and after a long shift. The goal is to understand how sleep deprivation impacts the body's ability to fight off…

This study creates a large database of men with prostate cancer who choose prostate ablation (a minimally invasive treatment) instead of active surveillance or more aggressive therapies. Researchers will collect medical records from up to 3,000 participants to see how well ablati…

This study looks at whether giving sleep tips to expecting parents can help their babies sleep longer and have fewer sleep problems. About 391 families will take part. Some parents will get regular sleep advice by email and fill out surveys, while others will not. Researchers wil…

This study looks at why the drug oxytocin sometimes fails to stop heavy bleeding after a C-section. Researchers will measure how the drug moves through the body and how well it makes the uterus contract. About 100 women having planned C-sections will take part. The goal is to fin…

This study looks at why a common gut bacterium, Pseudomonas aeruginosa, becomes deadly in critically ill patients. Researchers will collect stool samples from 100 ICU patients to see how the gut environment triggers the bacteria to turn on their virulence genes. The goal is to un…

This study looks at how often infections occur in broken bones around hip and knee replacements. Researchers will test tissue samples from 200 adults to find out what germs are present and what factors predict infection. The goal is to create clearer guidelines for diagnosing and…