University Of Chicago

This study tested a new drug called xevinapant combined with standard chemotherapy (carboplatin and paclitaxel) and radiation for people with advanced head and neck cancer who cannot take the usual chemo drug cisplatin. The main goal was to find the safest dose of xevinapant to u…

This study tested whether a low dose of tocilizumab, a drug used for arthritis, could help hospitalized COVID-19 patients with lung inflammation recover faster. It included 85 adults who were not on a breathing machine. The trial was stopped early, but the results may help guide …

This study tested whether taking a pill containing special gut bacteria (EDP1503) could make standard immunotherapy (pembrolizumab) work better for people with advanced melanoma. Eight adults with melanoma that could not be removed by surgery or had spread took the bacteria pill …

This study looked at whether a lower dose of the prostate cancer drug abiraterone can still control the disease. About 50 men with prostate cancer who were starting abiraterone for the first time took part. The goal was to find the smallest effective dose by measuring hormone lev…

This study tested the drug pembrolizumab in people with a fast-growing lymphoma (DLBCL) that had come back or not responded to other treatments. Only patients whose cancer had a specific genetic change in PD-L1 were included. The study was stopped early after enrolling just 5 par…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and mifepristone (a hormone blocker)—in people with advanced HER2-negative breast cancer. The goal was to see if the combination could shrink tumors. The study included 24 participants and was stopped e…

This study tested a new, fast, and low-cost MRI method to screen for breast cancer in women with dense breasts or moderate risk. The goal was to see if this MRI could find cancers earlier and more accurately than standard mammograms. The study enrolled 166 women and compared MRI …

This study aimed to see if taking glutathione by mouth is safe and doable for children and teens with autism. The researchers planned to include 24 participants but stopped early with only 6 enrolled. The focus was on checking safety and practical use, not on curing autism.

This study looked at whether letting patients manage their own sternal precautions after heart surgery leads to better quality of life without increasing pain or complications. Ten adults who had heart surgery were followed for up to a year. The goal was to see if a self-managed …

This study looked at whether applying gentle traction (pulling) to the leg before surgery makes it easier for surgeons to fix a broken thigh bone. The researchers compared patients who got traction to those who did not, measuring how long the surgery took, pain levels, and blood …

This study looked at why some multiple myeloma patients develop shortness of breath when taking the drug carfilzomib. Researchers used an FDA-approved device called EndoPAT to check blood vessel health and see if it relates to breathing problems. The goal was to find ways to pred…

This study aimed to find a genetic link in people with Hidradenitis Suppurativa (HS), a chronic skin condition causing painful lumps. Researchers collected DNA from 97 participants, including affected individuals and their family members, to search for rare gene variants. The goa…