University Of Chicago

This study tested whether a low dose of tocilizumab, a drug used for arthritis, could help hospitalized COVID-19 patients with lung inflammation who were not on a breathing machine. The goal was to see if it sped up recovery and reduced deaths. The trial was stopped early, but re…

This early-stage trial tested an experimental drug called xevinapant combined with standard chemotherapy and radiation in people with head and neck cancer who cannot take the usual drug cisplatin. The goal was to find the safest dose of xevinapant. The study was terminated early,…

This study tested the drug pembrolizumab in people with a hard-to-treat type of lymphoma (DLBCL) that has certain genetic changes in the PD-L1 gene. The goal was to see if the drug could shrink tumors. However, the study was stopped early after enrolling only 5 participants, so t…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and mifepristone (a hormone blocker)—in people with advanced HER2-negative breast cancer. The goal was to see if the combination could shrink tumors. The study was stopped early after enrolling 24 parti…

This study tested whether taking a pill containing gut bacteria (EDP1503) could help the immunotherapy drug pembrolizumab (Keytruda) work better in people with advanced melanoma. The trial included two groups: those who had never received anti-PD1 therapy and those whose cancer h…

This study looked at whether men with prostate cancer could take a lower dose of the drug abiraterone (combined with prednisone) and still control their cancer. About 50 men who had never taken abiraterone before were enrolled. The goal was to find the smallest dose that still lo…

This study tested a new, fast, and low-cost MRI method for breast cancer screening in women with dense breasts or moderate risk. The goal was to see if this MRI could find cancers earlier and more accurately than standard mammograms. The study enrolled 166 women and compared MRI …

This study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…

This study looked at whether using skeletal traction (a gentle pull on the leg) before surgery for a broken thigh bone makes the operation easier and reduces pain and blood loss. It included 18 adults who had surgery within 24 hours of their injury. The study was stopped early, s…

This study aimed to see if taking glutathione by mouth is safe and practical for children and teens with autism. Researchers planned to enroll 24 participants but stopped early with only 6. The goal was to measure changes in behavior and social skills over 12 weeks.

This study aimed to find out why some multiple myeloma patients develop shortness of breath when taking the drug carfilzomib. Researchers used an FDA-approved finger device called EndoPAT to check blood vessel health and tracked symptoms through surveys. The study enrolled 50 adu…

This study aimed to find a genetic link or family trait that connects people with Hidradenitis Suppurativa (HS), a painful skin condition. Researchers collected blood or saliva samples from 97 participants, including affected individuals and their family members, to analyze DNA f…