University Of Chicago

This study tests whether training pharmacy technicians can help more people with HIV get long-acting injectable medication at community clinics. About 465 participants will be observed or interviewed to see if this approach increases the number of people starting the shots. The g…

This study tests whether lactulose, a type of sugar, can make immunotherapy more effective for people with advanced cancer. About 55 participants will take lactulose alongside their standard immunotherapy drugs. The goal is to see if lactulose increases helpful gut bacteria and i…

This study looks at whether daily step counts can be used as a simple way to track how well vulnerable patients with advanced prostate cancer are doing on a combination of darolutamide and standard hormone therapy. About 80 adults who are frail or have other health issues will we…

This study looks at whether intensive counseling, with or without a medication called cytisine, can help people with HIV quit smoking and cut down on heavy drinking. The trial will enroll 300 adults in Nairobi, Kenya, who smoke and drink heavily. The goal is to find better ways t…

This study tests the drug Enhertu in 43 people with newly diagnosed, advanced HER2-positive cancer of the esophagus, stomach, or gastroesophageal junction who are too weak for standard chemotherapy. Participants receive Enhertu by IV every 3 weeks. The goal is to see how many pat…

This study tests whether adding fianlimab to the standard drug cemiplimab can better prevent cancer from returning in people with HPV-positive head and neck cancer who have tiny amounts of cancer still detectable after initial treatment. About 68 adults will receive either cemipl…

This study tests whether adding fianlimab to standard cemiplimab and chemotherapy can better shrink advanced head and neck cancers in adults with HPV-positive disease. About 90 participants will receive either the two-drug or three-drug combination before radiation. The goal is t…

This early-phase study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have not responded to standard therapies. The treatment uses the patient's own immune cells, which are genetically modified to better recognize and attack cancer cells,…

This study tests whether giving young people living with HIV a guaranteed income of $500 per month for 18 months helps them stay in care and achieve viral suppression. About 304 participants aged 18-35 who have faced financial hardship will be randomly assigned to receive either …

This study tests if a continuous glucose monitor (CGM) worn for a few days can spot early signs of diabetes in women who had gestational diabetes. About 50 participants will wear the monitor and then take a standard glucose drink test 4-12 weeks after giving birth. If the CGM wor…

This study tests whether aripiprazole, a medication already used for other conditions, can reduce the urge to pull hair or pick skin in adults with trichotillomania or skin-picking disorder. About 100 participants will take either aripiprazole or a placebo daily for 6 weeks, with…

This study tests whether a trained peer mentor, along with personalized resource lists and text messages over 12 months, can reduce loneliness and help caregivers of people with dementia find end-of-life resources. About 330 caregivers will take part. The goal is to ease the burd…

This study looks at whether text message reminders can help teens and adults (ages 15-39) with acute lymphoblastic leukemia (ALL) take their oral chemotherapy pills on time during the maintenance phase of treatment. About 38 participants will be split into two groups: one gets fr…

This study tests whether valbenazine can safely reduce symptoms in adults with moderate-to-severe obsessive-compulsive disorder (OCD). Thirty participants will receive both the drug and a placebo at different times to compare effects. The main goal is to see if OCD severity score…

This study tests if low-dose radiation can safely ease joint pain caused by immunotherapy cancer treatment. About 20 adults with cancer who developed arthritis from their immunotherapy will receive radiation to up to 3 painful joints. The goal is to see if this approach is safe a…

This study tests if a weekly injection of semaglutide (Wegovy) can reduce hair-pulling in people with trichotillomania. Ten adults aged 18-75 with daily pulling will receive the drug for several weeks. Researchers will measure changes in pulling severity and overall improvement.

This study will test whether personalized 3D-printed models of a patient's own anatomy can help transgender individuals better understand peritoneal vaginoplasty surgery. Researchers hope these models will improve patient education, communication with surgeons, and potentially re…

This study creates a database to track how well Aquablation (a waterjet procedure) works for men with an enlarged prostate (BPH). Researchers will collect information from medical records of 3,000 men who have had or will have the procedure as part of their normal care. No extra …

This study looks at whether certain bacteria in the stool can help predict or even cause colorectal cancer to come back after surgery. Researchers will collect stool, blood, and tumor samples from 107 adults before and after their operation. The goal is to understand how these ba…

This study will test whether taking apple cider vinegar every day for a short time changes the chemistry of urine in adults, both those who have had calcium oxalate kidney stones and those who haven't. Researchers will measure substances in urine like citrate, pH, calcium, and ca…

This study looks at whether follow-up visits done by video or phone (telehealth) are as satisfying for patients as in-person clinic visits after minimally invasive gynecologic surgery. About 100 women having laparoscopic or robotic surgery will be randomly assigned to one type of…

This study looks at how the bacteria in your gut (microbiome) might influence diarrhea and other stomach issues caused by the breast cancer drug abemaciclib. It involves 20 adults with HR+/HER2- breast cancer. First, researchers will collect stool samples to study gut bacteria. T…