University Of Chicago

This trial tests whether high-dose nicotinamide, a form of vitamin B3, can slow the loss of retinal nerve cells in adults with mild to moderate open-angle glaucoma. Participants already on standard glaucoma treatment will be randomly assigned to also take nicotinamide tablets or …

This trial asks whether formal outpatient physical therapy leads to better recovery than a self-guided home exercise program for people who had surgery for a broken thigh or shin bone. Participants will be randomly assigned to one of the two programs and followed for a year with …

This trial tests whether tirzepatide, a medication used for weight management, can reduce the rapid weight gain and metabolic changes caused by lorlatinib, a targeted therapy for ALK-positive non-small cell lung cancer. Adults already taking lorlatinib will receive weekly tirzepa…

This pilot trial is testing a smartphone app that acts like a personal coach to help adults with uncontrolled high blood pressure improve their self-care. The app provides education and interactive coaching to encourage medication adherence and healthy habits. The study will enro…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study tests whether a weekly injection of semaglutide (Wegovy), a drug used for weight loss and diabetes, can help people with trichotillomania (hair-pulling disorder). Ten adults aged 18-75 with daily hair pulling will receive the drug for several weeks. Researchers will me…

This study tests whether pharmacy technicians can help people with HIV get long-acting injectable medication more easily at community clinics in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to improve access to modern HIV tr…

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study tests whether adding fianlimab to the standard cemiplimab plus chemotherapy can better shrink tumors in adults with advanced HPV-positive head and neck cancer. About 90 participants will receive either the two-drug or three-drug combination before radiation. The goal i…

This study tests the drug Enhertu in 43 people with newly diagnosed HER2-positive stomach, esophageal, or gastroesophageal junction cancer that has spread. Participants have a lower physical ability (ECOG 2) and will receive Enhertu by IV every 3 weeks. The main goal is to see ho…

This study looks at whether daily step counts can help monitor how well vulnerable patients with metastatic hormone-sensitive prostate cancer are doing on a combination of darolutamide and standard hormone therapy. About 80 adults who are frail or have other health issues will we…

This study tests whether aripiprazole (Abilify) can reduce urges and behaviors in adults with trichotillomania (hair-pulling) or skin-picking disorder. One hundred participants will receive either the drug or a placebo for 6 weeks. Researchers will track symptom changes using sta…

This study tests whether placing a pH monitoring probe closer to the stomach (1 cm above the squamocolumnar junction) instead of the standard 6 cm position improves detection of acid reflux in women and people with lower body weight. Participants receive two probes simultaneously…

Researchers at the University of Chicago are testing whether adding a single-session pain management class called Empowered Relief to standard care helps women with chronic pelvic pain more than standard care alone. The trial enrolls 100 women aged 18 to 70 who have had pelvic pa…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study tests whether valbenazine can safely reduce symptoms in adults with moderate-to-severe obsessive-compulsive disorder (OCD). About 30 participants will receive either the drug or a placebo in a crossover design, meaning everyone gets both over time. The main goal is to …

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests whether low-dose radiation can safely ease arthritis pain and swelling that some cancer patients get from immunotherapy. About 20 adults with cancer who developed joint inflammation from their treatment will receive six small radiation doses over 2-3 weeks. The m…

This study looks at whether a procedure called therapeutic plasma exchange—which filters the blood—can help remove immune checkpoint inhibitor drugs from the body in people who develop severe immune-related side effects from cancer treatment. The trial will measure how drug level…

This trial investigates whether the common flavor enhancer monosodium glutamate (MSG) increases blood levels of imidazole propionate (ImP), a compound produced by gut bacteria from the amino acid histidine. Higher ImP levels have been linked to blood-sugar control issues. Healthy…

This study investigates whether a brief training task can change how people with anorexia nervosa value food. Participants view food images and focus on attributes like tastiness or healthiness, then make food choices. The goal is to see if this training makes their choices more …

This study will test whether taking apple cider vinegar every day for a short time changes the chemistry of urine in adults, both those with a history of calcium oxalate kidney stones and healthy volunteers. Researchers will measure levels of citrate, pH, calcium, and calcium oxa…

This registry will follow 3,000 men with benign prostatic hyperplasia (BPH) who undergo Aquablation, a waterjet-based procedure to remove excess prostate tissue. Researchers will collect data from medical records to evaluate how well the procedure improves urinary symptoms and it…

This study will test whether a continuous glucose monitor (CGM) worn for 14 days after childbirth can predict which women with a history of gestational diabetes are at risk for developing type 2 diabetes. Fifty participants will wear a blinded CGM device and then take a standard …

This study will collect blood samples, brain scans, and medical information from 270 people with penetrating brain injuries. The goal is to create a large research database that scientists can use to better understand these injuries and improve future treatments. Participants mus…

This study looks at how gut bacteria affect diarrhea and other stomach issues in people with HR+/HER2- breast cancer taking the drug abemaciclib. In the first part, researchers will collect stool samples to track bacteria changes. In the second part, a small group will try eating…

This study will test whether using 3D-printed models of a patient's own anatomy helps transgender individuals better understand peritoneal vaginoplasty surgery. Twenty adults seeking vaginoplasty at the University of Chicago will receive personalized 3D models to aid in education…

This study looks at whether certain bacteria in your stool can help predict if colon cancer will come back after surgery. Researchers will collect stool and blood samples from 107 adults before and after their surgery. They want to see if bacteria that break down collagen are lin…