University Of Chicago

This study is testing whether giving two cancer drugs—docetaxel (chemotherapy) and trastuzumab (a targeted therapy)—before surgery can help eliminate tumors in Nigerian women with HER2-positive breast cancer. The trial involves 53 women with stage II or III breast cancer who have…

This study is testing whether combining an immunotherapy drug (pembrolizumab) with a chemotherapy drug (docetaxel) can help control advanced thyroid and salivary gland cancers that have stopped responding to standard treatments. It will involve about 46 adults with these specific…

This study aims to see if multiple myeloma patients who show no detectable cancer after stem cell transplant can safely stop their long-term maintenance medications. Researchers will use advanced blood and imaging tests to identify patients with the lowest possible cancer levels.…

This study aims to find out which of two common add-on treatments works better to help a torn knee meniscus heal after surgical repair. Researchers are comparing a bone marrow stimulation technique with injections of platelet-rich plasma (PRP, a patient's own concentrated healing…

This study compares two maintenance treatments for multiple myeloma patients who have received a stem cell transplant. Researchers want to see if a three-drug combination (carfilzomib, lenalidomide, dexamethasone) works better than lenalidomide alone at preventing the cancer from…

This early-stage study is testing the safety of combining two drugs, venetoclax and decitabine, for adults with high-risk acute myeloid leukemia (AML). The main goal is to find the highest dose patients can tolerate without severe side effects. It is for patients whose cancer has…

This study is testing whether providing a continuous glucose monitor and a dedicated Patient Navigator can help people with type 1 diabetes who have struggled with severe complications or high blood sugar. It aims to see if this combination of technology and personal support impr…

This study is testing whether a virtual visit with a pharmacist after a hospital stay can help people with COPD. The goal is to teach patients how to use their inhalers correctly and manage their medications at home, which may help them avoid needing to return to the emergency ro…

This study is testing whether adding a targeted drug called inotuzumab ozogamicin to standard treatment can help adults with a specific, newly diagnosed type of acute lymphoblastic leukemia (Ph+ ALL) achieve a deep remission faster. The goal is to see if this approach leads to be…

This study is testing whether the drug sirolimus can prevent permanent lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. Hospitalized patients will be randomly assigned to receive different doses of sirolimus or standard care alone. Researchers will …

This study is testing a combination of four medications (daratumumab, carfilzomib, lenalidomide, and dexamethasone) as the first treatment for people newly diagnosed with multiple myeloma, a cancer of plasma cells in the bone marrow. It aims to see how well this combination works…

This study is testing a new, more targeted form of radiation to the bone marrow (called IMTMI) given with two chemotherapy drugs before a second stem cell transplant. The goal is to see if this combination is safe and can better prepare patients with advanced blood cancers (like …

This study aimed to see if using smaller or larger stitches when reconnecting the bladder after robotic prostate cancer surgery helps men regain bladder control faster. It planned to compare how many protective pads men needed daily six months after surgery using the two differen…

This study directly compares two different three-drug combinations for people newly diagnosed with multiple myeloma, a blood cancer. It aims to find out which treatment regimen is better at keeping the cancer from progressing and helps patients live longer without their disease g…

This study is testing a new way to care for Medicare patients who are frequently hospitalized. It assigns a special doctor, called a Comprehensive Care Physician, to see these patients both in the clinic and during any hospital stays. The goal is to build a stronger doctor-patien…

This study is testing a 6-month program to help patients lose weight so they can qualify for a kidney transplant. It involves diet counseling, personal training, and health monitoring. The goal is to see if this structured support helps patients reach a healthy weight for surgery…

This study is testing the safety of combining two immunotherapy drugs with a precise form of radiation in patients with advanced lung cancer that has spread. The main goal is to find the safest radiation dose for different body areas and to see if giving the radiation at the same…

This study aimed to see if taking a daily medication called Myfembree after fibroid removal surgery could help keep symptoms from returning longer than usual care. It planned to enroll women who had surgery for painful, heavy periods caused by fibroids. The goal was to see if the…

This study is testing whether a medication called tolcapone can help reduce symptoms of obsessive-compulsive disorder (OCD). Researchers are comparing tolcapone against a placebo in 49 adults with moderate to severe OCD over 8 weeks. The study also examines how the medication aff…

This study is testing whether a shorter course of radiation treatment is safe for adults whose Hodgkin or non-Hodgkin lymphoma has returned or not responded to standard treatments. Instead of the usual 5-6 weeks of radiation, researchers aim to find the highest safe dose that can…

This study is testing whether a remote heart monitoring program can help prevent heart problems in African American women who had preeclampsia during pregnancy. Twenty women will either use special equipment to track their blood pressure and weight from home or receive standard c…

This study tests whether using an online patient portal can improve screening for substance use disorders among people living with HIV. Researchers are comparing portal-based screening to usual clinic-based methods to see which approach reaches more patients and leads to better t…

This study aims to find out which treatment works better for adults with compulsive hair-pulling or skin-picking disorders: a medication called memantine or a specialized behavioral therapy. Each of the 26 participants will try both treatments for 8 weeks each. The researchers be…

This study is testing whether online group doctor visits help people better manage type 2 diabetes and related heart conditions. Researchers are comparing virtual group visits to regular individual care for 720 patients across Chicago health systems. The goal is to see if this ap…

This study tests whether a 24-week lifestyle program helps Black women with asthma manage their condition better through increased physical activity. Participants receive either group exercise sessions with text support or asthma education alone. Researchers will track asthma con…

This study is testing the safety of transplanting insulin-producing cells from donors into adults with severe, unstable type 1 diabetes. The goal is to see if this procedure can help control blood sugar levels, reduce or eliminate the need for insulin injections, and prevent dang…

This study is testing whether a drug called pembrolizumab can help prevent cancer from returning in people with high-risk head and neck cancer who have already finished their main treatment. About 100 patients will receive either the drug or a placebo for one year to see if it im…

This study is testing whether combining mammograms with MRI scans can help detect breast cancer earlier in women at high genetic or family risk. Researchers want to see if this two-part screening approach finds small cancers better than mammograms alone, especially in younger wom…

This study is testing a new blood test to see if it can spot the return of cancer better than current standard tests. It involves 55 adults with specific abdominal cancers who are having surgery. Researchers will take blood samples before and after surgery for one year to compare…

This study aims to find out if taking antibiotics for 6 extra days after getting a penile implant helps prevent infections. Researchers are testing this with 800 men who have erectile dysfunction and are getting a specific type of antibiotic-coated implant. The main goal is to se…

This study is testing whether adding a CPAP breathing machine to a standard diet and exercise program can better prevent diabetes in overweight adults with prediabetes and sleep apnea. Researchers want to see if treating sleep apnea improves blood sugar and heart health more than…

This study is testing whether a voice-activated app called EngAGE can help frail, homebound older adults improve their physical strength and social connections. It compares the app to standard paper exercise handouts. The goal is to see if using technology to guide exercises at h…

This study is testing if listening to nature sounds during a breast biopsy can help reduce patients' pain and anxiety. About 200 participants will be randomly assigned to either listen to nature sounds or receive standard supportive conversation during the procedure. Researchers …

This study aimed to test if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce severe suicidal thoughts and depression in people arriving at the emergency room. It planned to compare the gas to a placebo, given alongside standard emergency care, …

This study aims to see if moving patients with severe breathing failure from lying down to sitting or standing improves their oxygen levels. Researchers will carefully help 16 hospitalized adults who are on breathing machines to stand up while closely monitoring their safety. The…

This study aims to understand the genetic causes of chronic sinusitis. Researchers are collecting DNA samples from 1,200 adults who either have the condition or have normal sinuses, as confirmed by a recent CT scan. By comparing these groups, they hope to identify specific genes …

This study aimed to understand if the time of day people eat affects their body's natural hunger signals and metabolism, potentially influencing weight gain. It planned to look at overweight individuals to see if eating more calories later in the day changes hormone rhythms and h…

This study aims to understand the long-term physical and mental health challenges faced by people who survive severe COVID-19 with respiratory failure. Researchers will follow 500 patients for up to a year after leaving the hospital, comparing them to other ICU patients without C…

This study aims to understand how a safe, noninvasive brain stimulation technique affects the brain's memory circuits. Researchers will work with 12 patients who already have electrodes implanted for epilepsy monitoring to measure brain activity with high precision. The goal is t…

This study aims to understand how the community of bacteria in the gut changes when a person is critically ill in the hospital. Researchers will collect stool samples from 500 adult patients in the intensive care unit and track their health for a year after discharge. The goal is…

This small, early-stage study aims to understand how a specific brain network works in people with a common form of epilepsy. Researchers will test whether using a non-invasive magnetic stimulation device on the scalp can change memory performance and brain activity related to se…

This study is investigating whether the time of day you eat most of your calories affects your body's metabolism, insulin sensitivity, and blood pressure. Researchers are enrolling 200 overweight adults without diabetes to test if shifting calories to morning, evening, or spreadi…

This study is testing small, wearable sensors to measure movement during simple coordination tests. The goal is to better understand and track the progression of Spinocerebellar Ataxia, a neurological condition that affects balance and coordination. About 600 people, including th…

This study aims to understand how specific brain activity supports memory. Researchers will use safe, targeted brain stimulation techniques on a small group of participants while they perform memory tasks. The goal is to learn how to influence memory processes, which could guide …

This study aims to understand chronic sinusitis by exploring the community of bacteria living in the nose and sinuses. Researchers will collect samples from 285 adults with and without sinus conditions to create a detailed map of these bacteria. They hope to learn if specific bac…

This study aims to find out if people who have had general anesthesia many times (more than 20) are at higher risk of a frightening experience called 'awareness with recall,' where a patient wakes up and remembers events during surgery. Researchers will survey and review the medi…