University Of Chicago

This study compares two treatment regimens (KRd and VRd) in 250 adults newly diagnosed with multiple myeloma. The goal is to see which combination better delays cancer progression. Participants receive one of the two drug combos, and researchers track how long they live without t…

This study tests the safety of transplanting donor islet cells into people with difficult-to-control type 1 diabetes. The goal is to see if the cells can help stabilize blood sugar and reduce the need for insulin injections. Participants also receive anti-rejection drugs to prote…

This study tests whether a telehealth program can help COPD patients use their inhalers correctly and avoid repeat hospital visits. About 218 adults hospitalized with a COPD flare-up will receive a virtual home visit and pharmacy education within two weeks of discharge. The goal …

This study is for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation and has stopped responding to standard treatments. Researchers are testing the safety and effectiveness of combining two drugs, AVUTOMETINIB and cetuximab. The goal …

This study tests whether adding experimental drugs HB-201 and HB-202 to standard chemotherapy can shrink HPV16-positive throat tumors more effectively. The goal is to reduce the amount of radiation and chemotherapy needed afterward, potentially lowering side effects. About 35 adu…

This study tests whether virtual group visits can help adults with type 2 diabetes and related heart conditions better manage their health. About 720 participants will join online group sessions led by healthcare providers. The main goal is to see if these visits lower blood suga…

This early-stage study tests the safety of adding venetoclax to a standard chemotherapy drug, decitabine, for people with acute myeloid leukemia (AML) that is hard to treat. About 26 adults with high-risk AML will take part. The goal is to find the best dose and see how well the …

This study tests adding a targeted drug called inotuzumab ozogamicin (InO) to standard treatment for adults newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if this combination can make the cancer disappear faster an…

This study tests adding a precise, low-toxicity radiation to the bone marrow (IMTMI) along with standard chemotherapy before a second donor stem cell transplant. It includes up to 30 adults with blood cancers like leukemia that have returned after a first transplant. The goal is …

This study tests whether a supervised fitness program can help people with obesity lose weight so they can become eligible for a kidney transplant. Ten adults who are currently inactive on the transplant waitlist due to a high body mass index will take part. The main goal is to s…

This study tests a combination of chemotherapy (Taxotere) and a targeted drug (trastuzumab) given before surgery to shrink tumors in Nigerian women with HER2-positive breast cancer. The main goal is to see how many women have no cancer cells left in the breast or lymph nodes at t…

This study tests whether sirolimus, a drug used to prevent organ rejection, can reduce the risk of lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. About 60 adults will receive sirolimus to see if it prevents long-term lung damage. The goal is to im…

This early-phase study tests whether adding the drug acetazolamide to standard chemotherapy (temozolomide) is safe for people with a newly diagnosed, aggressive brain cancer called glioblastoma. Only 10 participants with a specific genetic marker (MGMT promoter methylation) are e…

This study compares two biologic augmentation methods for repairing torn meniscus in the knee: bone marrow venting procedure (BMVP) and platelet-rich plasma (PRP) injection. The goal is to see which approach leads to better function and fewer re-tears. The trial enrolled 146 part…

This study tests whether adding two drugs (carfilzomib and dexamethasone) to the standard maintenance drug lenalidomide after a stem-cell transplant can keep multiple myeloma from coming back longer. About 180 adults who have already had a transplant and are in at least stable di…

This study planned to see if taking Myfembree (a daily pill for heavy bleeding) after fibroid surgery could delay the return of fibroids and symptoms compared to standard care. It was designed for premenopausal women with fibroids who had surgery. However, the study was withdrawn…

This study tests a combination of two drugs—pembrolizumab (an immunotherapy) and docetaxel (chemotherapy)—in people with advanced thyroid or salivary gland cancers that are not responding to standard treatments. The goal is to see if the combo can shrink tumors and help patients …

This study is for people with stage IV non-small cell lung cancer. It tests whether giving immunotherapy drugs (nivolumab and ipilimumab) at the same time or right after targeted radiation is safe. The goal is to find the best radiation dose for different tumor locations. About 7…

This study tests whether adjusting chemotherapy doses based on a patient's genetics can improve outcomes for people with advanced stomach or esophageal cancer that has spread to nearby tissues or lymph nodes. About 36 participants will receive a chemotherapy regimen called mFOLFI…

This study tests whether using a continuous glucose monitor (CGM) with the help of a Patient Navigator can improve diabetes management and quality of life for people with type 1 diabetes. The study includes 150 participants aged 14 to 64 who have had serious diabetes complication…

This study tests a combination of four drugs (daratumumab, carfilzomib, lenalidomide, and dexamethasone) as the first treatment for people newly diagnosed with multiple myeloma, a type of blood cancer. The goal is to see how well the treatment works at eliminating cancer cells an…

This study looks at whether combining mammograms and breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the scr…

This study looks at whether adding CPAP therapy (a machine that helps you breathe during sleep) to standard lifestyle changes can lower the risk of developing diabetes in people who have prediabetes and are overweight. About 174 participants will be followed for 6 months to see i…

This pilot study tests whether a guideline-based heart health program can prevent heart function decline in African American women after preeclampsia. Twenty women who had preeclampsia and high blood pressure will be followed for 3 months to see if the program improves heart stra…

This study aimed to see if a one-hour session of breathing 50% nitrous oxide (laughing gas) could reduce pain in people with fibromyalgia. It planned to enroll adults aged 18-75 with moderate to severe pain. However, the study was withdrawn before any participants were enrolled, …

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in adults visiting the emergency department. Participants would have had major depressive disorder and be at immediate risk. The trial …

This study tests whether a voice-activated app called EngAGE can help frail, homebound older adults (age 60+) with at least two chronic conditions improve their physical function and social connection. Participants use the app at home, and researchers measure changes in chair sta…

This study tests whether listening to nature sounds (like birds or water) during a breast core biopsy can lower pain and anxiety compared to standard supportive conversation. About 200 adults having a breast biopsy will be randomly assigned to either nature sounds or usual care. …

This study looks at whether taking oral antibiotics for an extra 6 days after getting a penile implant can lower the chance of infection. It involves 800 men with erectile dysfunction who are getting a specific type of implant. The goal is to see if the extra antibiotics reduce t…

This study tests whether tolcapone, a drug currently used for Parkinson's disease, can safely reduce symptoms in adults with moderate to severe obsessive-compulsive disorder (OCD). About 49 participants will receive either tolcapone or a placebo to compare changes in OCD severity…

This study compares two treatments for body-focused repetitive behaviors like hair-pulling and skin-picking: a medication called memantine and a type of behavioral therapy. About 26 adults will try memantine for 8 weeks, then switch to therapy for 8 weeks. The goal is to see whic…

This study aimed to see if breathing nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. It planned to compare four weekly sessions of nitrous oxide to a placebo. However, the study was withdrawn before…

This study tests whether giving radiation over a shorter time (instead of the usual 5-6 weeks) is safe for people with lymphoma that has returned or not responded to treatment. About 30 participants will receive different shortened radiation doses to find the safest one. The goal…

This study tests a 24-week physical activity program designed specifically for Black women with asthma. The goal is to see if the program improves asthma control and quality of life compared to standard asthma education. About 224 women will take part, and researchers will also c…

This study looks at people with end-stage kidney disease who need a special connection in their arm for dialysis, called a brachiocephalic fistula. A common problem is that a vein in the upper chest narrows over time, which can make dialysis harder. Researchers are using scans an…

This study tracks changes in the gut bacteria (microbiome) of 500 critically ill adults admitted to the intensive care unit. Researchers want to see if these changes are linked to how long patients stay in the hospital and their risk of death up to one year later. The goal is to …

This study looks at whether people with multiple myeloma who have no detectable cancer after a stem cell transplant and at least one year of maintenance therapy can safely stop taking their medication. Researchers will use advanced imaging and lab tests to find even the tiniest t…

This study tests a program called ePORTAL HIV-S to make it easier for people with HIV to get screened for substance use disorders. The program uses online patient portals and clinic-based screening, even when patients don't have a scheduled appointment. Researchers will track how…

This study looks at whether special brain wave tests (EEGs) can help doctors know if the medicine fenfluramine will work for people with Lennox-Gastaut syndrome, a severe form of epilepsy. About 20 children and adults aged 2 to 35 will take part. Researchers will check EEG change…

This study was designed to see if changing when you eat affects natural body chemicals linked to pleasure eating and metabolism. Researchers planned to measure hunger, blood sugar, and weight changes in healthy adults. However, the study was withdrawn before any participants were…

This study tests a home visiting program called Thirty Million Words for low-income families with toddlers aged 13-16 months. The goal is to see if coaching parents to talk and interact more with their child improves the child's language, thinking, and social skills, and helps th…

This study looks at whether moving from lying flat to sitting upright improves oxygen levels in patients with respiratory failure who are on a breathing machine. Researchers will measure oxygen and carbon dioxide in the blood to see if position makes a difference. The study invol…

This study tests whether a real-time computer alert that predicts acute kidney injury (AKI) can help doctors step in early to prevent or reduce kidney damage. About 180 hospitalized adults at risk for AKI will be randomly assigned to either standard care or early kidney specialis…

This study looks at how sleep apnea might cause pre-diabetes in overweight people. Researchers will measure stress hormones in the blood of 300 adults with sleep apnea and pre-diabetes. The goal is to understand the connection, not to test a treatment.

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, or healthy sinuses. Researchers want to find out if certain bacteria trigger inflammation that leads to long-term sinus problems. The goal is to gather basic knowledge tha…

This study looks at how the timing of meals affects the way the body uses energy (metabolism) and insulin sensitivity. Researchers will study 200 overweight or obese adults aged 30-75 who sleep 6.5-9 hours nightly. No treatment is given; the goal is simply to understand how eatin…

This study compares different outreach methods to see which works best for getting African Americans to join early phase cancer treatment trials. About 134 patients and their doctors will take part. The goal is to find ways to make cancer research more inclusive.

This study looks at a new way of caring for Medicare patients who are at high risk of being hospitalized. Instead of seeing different doctors in the hospital and clinic, each patient gets one doctor who manages their care in both places. The goal is to see if this approach improv…

This study follows 800 young adults who drink alcohol regularly to understand why some people develop drinking problems. Participants complete mood questionnaires after consuming alcohol and other common substances, then are interviewed for at least two years to track their drink…

This study tests body-worn sensors to measure movement during simple coordination tests in people with spinocerebellar ataxia (SCA) and healthy volunteers. The goal is to see if these sensors can better track disease severity and progression than current methods. 600 participants…

This study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-health marker called BDNF in people with multiple sclerosis, long-COVID, or leukemia (in remission) who also have obesity and memory or thinking problems. About 30 participants w…

This study follows 500 adults who were in the ICU with breathing failure. Researchers want to see if COVID-19 patients have different long-term mental and physical problems compared to those without COVID-19. The goal is to understand these differences so doctors can better treat…

This study aimed to find out whether using smaller or larger stitches during robotic prostate surgery helps men regain bladder control sooner. It planned to compare how many incontinence pads men needed six months after surgery. However, the study was withdrawn before any partici…

This study looks at whether a simple blood test can find signs of cancer coming back after surgery for colorectal or appendix cancer that has spread to the belly lining. About 55 people who are having surgery plus heated chemotherapy will give blood samples before and after the p…

This study aims to understand how different parts of the brain work together to form memories. Researchers will use brain stimulation and EEG recordings in 44 adults to see which brain signals are important for memory. The goal is to learn more about memory mechanisms, which coul…

This study looks at whether people who have had general anesthesia many times (more than 20) are more likely to be aware and remember things during a future surgery. Researchers will survey and review medical records of 1000 patients aged 7 and older. The goal is to help doctors …

This study aims to find genes that may play a role in chronic sinusitis. Researchers will compare DNA from 1,200 adults—some with the condition and some without—to identify genetic differences. The goal is to better understand why some people get chronic sinusitis, not to test a …

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study aims to understand how a gentle, noninvasive brain stimulation technique affects memory. Researchers will record brain activity from electrodes already placed inside the skulls of 12 adults with epilepsy. The goal is to learn which brain signals are important for memor…

This study looks at how a type of brain stimulation called TMS affects memory and seizure activity in people with mesial temporal lobe epilepsy. About 34 adults will have memory tests, brain scans, and EEG before and after TMS. The goal is to see if targeting a specific brain net…